Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008134 | molecular_function | transcription factor binding |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0031463 | cellular_component | Cul3-RING ubiquitin ligase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 701 |
| Chain | Residue |
| A | CYS434 |
| A | HIS436 |
| A | ARG459 |
| A | ARG494 |
| A | ARG498 |
| A | HOH830 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 702 |
| Chain | Residue |
| A | HOH811 |
| A | HOH880 |
| A | HOH882 |
| A | HOH883 |
| A | PRO361 |
| A | ASN381 |
| A | HIS553 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 703 |
| Chain | Residue |
| A | ALA356 |
| A | ASP357 |
| A | ARG551 |
| A | HIS552 |
| A | GLU593 |
| A | ARG596 |
| A | DMS716 |
| A | HOH825 |
| A | HOH903 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 704 |
| Chain | Residue |
| A | HIS451 |
| A | LEU452 |
| A | HOH804 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 705 |
| Chain | Residue |
| A | ILE435 |
| A | HIS437 |
| A | SER438 |
| A | SER439 |
| A | ARG494 |
| A | HOH802 |
| A | HOH864 |
| A | HOH945 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue DMS A 706 |
| Chain | Residue |
| A | ARG494 |
| A | ASN495 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue DMS A 707 |
| Chain | Residue |
| A | THR388 |
| A | ASP389 |
| A | SER390 |
| A | SER391 |
| A | ARG470 |
| A | HOH806 |
| A | HOH852 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 708 |
| Chain | Residue |
| A | LEU457 |
| A | THR458 |
| A | ARG459 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue DMS A 709 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 710 |
| Chain | Residue |
| A | TYR525 |
| A | GLN530 |
| A | SER555 |
| A | QH2719 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 711 |
| Chain | Residue |
| A | ALA407 |
| A | SER408 |
| A | HOH949 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 712 |
| Chain | Residue |
| A | CYS368 |
| A | VAL369 |
| A | ALA607 |
| A | HOH935 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue DMS A 713 |
| Chain | Residue |
| A | ARG459 |
| A | ARG498 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 714 |
| Chain | Residue |
| A | ASN482 |
| A | ARG483 |
| A | ASP526 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 715 |
| Chain | Residue |
| A | ILE421 |
| A | HIS424 |
| A | TYR426 |
| A | ARG442 |
| A | PRO492 |
| A | HOH943 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue DMS A 716 |
| Chain | Residue |
| A | ARG354 |
| A | LEU355 |
| A | ASP357 |
| A | SO4703 |
| A | HOH825 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 717 |
| Chain | Residue |
| A | ARG415 |
| A | GLY433 |
| A | HIS436 |
| A | ILE461 |
| A | PHE478 |
| A | QH2719 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 718 |
| Chain | Residue |
| A | LEU452 |
| A | VAL453 |
| A | ALA454 |
| A | ASN495 |
| site_id | AE1 |
| Number of Residues | 14 |
| Details | binding site for residue QH2 A 719 |
| Chain | Residue |
| A | TYR334 |
| A | ARG380 |
| A | ASN414 |
| A | ARG415 |
| A | ARG483 |
| A | SER508 |
| A | GLY509 |
| A | PHE577 |
| A | SER602 |
| A | GLY603 |
| A | DMS710 |
| A | DMS717 |
| A | HOH834 |
| A | HOH841 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 45 |
| Details | Repeat: {"description":"Kelch 1"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 50 |
| Details | Repeat: {"description":"Kelch 2"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"Kelch 3"} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"Kelch 4"} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 45 |
| Details | Repeat: {"description":"Kelch 5"} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"Kelch 6"} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Sensor for electrophilic agents","evidences":[{"source":"PubMed","id":"20498371","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"S-cGMP-cysteine","evidences":[{"source":"PubMed","id":"20498371","evidenceCode":"ECO:0000269"}]} |
