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6ZEJ

Structure of PP1-Phactr1 chimera [PP1(7-304) + linker (SGSGS) + Phactr1(526-580)]

Functional Information from GO Data
ChainGOidnamespacecontents
A0000164cellular_componentprotein phosphatase type 1 complex
A0000781cellular_componentchromosome, telomeric region
A0001111biological_processRNA polymerase II promoter clearance
A0004721molecular_functionphosphoprotein phosphatase activity
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0005506molecular_functioniron ion binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005814cellular_componentcentriole
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005912cellular_componentadherens junction
A0005977biological_processglycogen metabolic process
A0005979biological_processregulation of glycogen biosynthetic process
A0005981biological_processregulation of glycogen catabolic process
A0006470biological_processprotein dephosphorylation
A0008157molecular_functionprotein phosphatase 1 binding
A0010288biological_processresponse to lead ion
A0016787molecular_functionhydrolase activity
A0016791molecular_functionphosphatase activity
A0030324biological_processlung development
A0032922biological_processcircadian regulation of gene expression
A0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
A0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
A0042587cellular_componentglycogen granule
A0042752biological_processregulation of circadian rhythm
A0043021molecular_functionribonucleoprotein complex binding
A0043025cellular_componentneuronal cell body
A0043153biological_processentrainment of circadian clock by photoperiod
A0043197cellular_componentdendritic spine
A0043204cellular_componentperikaryon
A0043247biological_processtelomere maintenance in response to DNA damage
A0043558biological_processregulation of translational initiation in response to stress
A0044877molecular_functionprotein-containing complex binding
A0045725biological_processpositive regulation of glycogen biosynthetic process
A0046872molecular_functionmetal ion binding
A0046914molecular_functiontransition metal ion binding
A0048754biological_processbranching morphogenesis of an epithelial tube
A0050821biological_processprotein stabilization
A0051301biological_processcell division
A0060828biological_processregulation of canonical Wnt signaling pathway
A0070062cellular_componentextracellular exosome
A0072357cellular_componentPTW/PP1 phosphatase complex
A0097225cellular_componentsperm midpiece
A0097229cellular_componentsperm end piece
A0098609biological_processcell-cell adhesion
A0098641molecular_functioncadherin binding involved in cell-cell adhesion
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
A2000806biological_processpositive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
A2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
D0000164cellular_componentprotein phosphatase type 1 complex
D0000781cellular_componentchromosome, telomeric region
D0001111biological_processRNA polymerase II promoter clearance
D0004721molecular_functionphosphoprotein phosphatase activity
D0004722molecular_functionprotein serine/threonine phosphatase activity
D0005506molecular_functioniron ion binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005814cellular_componentcentriole
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005912cellular_componentadherens junction
D0005977biological_processglycogen metabolic process
D0005979biological_processregulation of glycogen biosynthetic process
D0005981biological_processregulation of glycogen catabolic process
D0006470biological_processprotein dephosphorylation
D0008157molecular_functionprotein phosphatase 1 binding
D0010288biological_processresponse to lead ion
D0016787molecular_functionhydrolase activity
D0016791molecular_functionphosphatase activity
D0030324biological_processlung development
D0032922biological_processcircadian regulation of gene expression
D0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
D0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
D0042587cellular_componentglycogen granule
D0042752biological_processregulation of circadian rhythm
D0043021molecular_functionribonucleoprotein complex binding
D0043025cellular_componentneuronal cell body
D0043153biological_processentrainment of circadian clock by photoperiod
D0043197cellular_componentdendritic spine
D0043204cellular_componentperikaryon
D0043247biological_processtelomere maintenance in response to DNA damage
D0043558biological_processregulation of translational initiation in response to stress
D0044877molecular_functionprotein-containing complex binding
D0045725biological_processpositive regulation of glycogen biosynthetic process
D0046872molecular_functionmetal ion binding
D0046914molecular_functiontransition metal ion binding
D0048754biological_processbranching morphogenesis of an epithelial tube
D0050821biological_processprotein stabilization
D0051301biological_processcell division
D0060828biological_processregulation of canonical Wnt signaling pathway
D0070062cellular_componentextracellular exosome
D0072357cellular_componentPTW/PP1 phosphatase complex
D0097225cellular_componentsperm midpiece
D0097229cellular_componentsperm end piece
D0098609biological_processcell-cell adhesion
D0098641molecular_functioncadherin binding involved in cell-cell adhesion
D0098793cellular_componentpresynapse
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
D2000806biological_processpositive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
D2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
F0000164cellular_componentprotein phosphatase type 1 complex
F0000781cellular_componentchromosome, telomeric region
F0001111biological_processRNA polymerase II promoter clearance
F0004721molecular_functionphosphoprotein phosphatase activity
F0004722molecular_functionprotein serine/threonine phosphatase activity
F0005506molecular_functioniron ion binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0005783cellular_componentendoplasmic reticulum
F0005814cellular_componentcentriole
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0005912cellular_componentadherens junction
F0005977biological_processglycogen metabolic process
F0005979biological_processregulation of glycogen biosynthetic process
F0005981biological_processregulation of glycogen catabolic process
F0006470biological_processprotein dephosphorylation
F0008157molecular_functionprotein phosphatase 1 binding
F0010288biological_processresponse to lead ion
F0016787molecular_functionhydrolase activity
F0016791molecular_functionphosphatase activity
F0030324biological_processlung development
F0032922biological_processcircadian regulation of gene expression
F0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
F0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
F0042587cellular_componentglycogen granule
F0042752biological_processregulation of circadian rhythm
F0043021molecular_functionribonucleoprotein complex binding
F0043025cellular_componentneuronal cell body
F0043153biological_processentrainment of circadian clock by photoperiod
F0043197cellular_componentdendritic spine
F0043204cellular_componentperikaryon
F0043247biological_processtelomere maintenance in response to DNA damage
F0043558biological_processregulation of translational initiation in response to stress
F0044877molecular_functionprotein-containing complex binding
F0045725biological_processpositive regulation of glycogen biosynthetic process
F0046872molecular_functionmetal ion binding
F0046914molecular_functiontransition metal ion binding
F0048754biological_processbranching morphogenesis of an epithelial tube
F0050821biological_processprotein stabilization
F0051301biological_processcell division
F0060828biological_processregulation of canonical Wnt signaling pathway
F0070062cellular_componentextracellular exosome
F0072357cellular_componentPTW/PP1 phosphatase complex
F0097225cellular_componentsperm midpiece
F0097229cellular_componentsperm end piece
F0098609biological_processcell-cell adhesion
F0098641molecular_functioncadherin binding involved in cell-cell adhesion
F0098793cellular_componentpresynapse
F0098794cellular_componentpostsynapse
F0098978cellular_componentglutamatergic synapse
F0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
F2000806biological_processpositive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
F2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
I0000164cellular_componentprotein phosphatase type 1 complex
I0000781cellular_componentchromosome, telomeric region
I0001111biological_processRNA polymerase II promoter clearance
I0004721molecular_functionphosphoprotein phosphatase activity
I0004722molecular_functionprotein serine/threonine phosphatase activity
I0005506molecular_functioniron ion binding
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005730cellular_componentnucleolus
I0005737cellular_componentcytoplasm
I0005783cellular_componentendoplasmic reticulum
I0005814cellular_componentcentriole
I0005829cellular_componentcytosol
I0005886cellular_componentplasma membrane
I0005912cellular_componentadherens junction
I0005977biological_processglycogen metabolic process
I0005979biological_processregulation of glycogen biosynthetic process
I0005981biological_processregulation of glycogen catabolic process
I0006470biological_processprotein dephosphorylation
I0008157molecular_functionprotein phosphatase 1 binding
I0010288biological_processresponse to lead ion
I0016787molecular_functionhydrolase activity
I0016791molecular_functionphosphatase activity
I0030324biological_processlung development
I0032922biological_processcircadian regulation of gene expression
I0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
I0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
I0042587cellular_componentglycogen granule
I0042752biological_processregulation of circadian rhythm
I0043021molecular_functionribonucleoprotein complex binding
I0043025cellular_componentneuronal cell body
I0043153biological_processentrainment of circadian clock by photoperiod
I0043197cellular_componentdendritic spine
I0043204cellular_componentperikaryon
I0043247biological_processtelomere maintenance in response to DNA damage
I0043558biological_processregulation of translational initiation in response to stress
I0044877molecular_functionprotein-containing complex binding
I0045725biological_processpositive regulation of glycogen biosynthetic process
I0046872molecular_functionmetal ion binding
I0046914molecular_functiontransition metal ion binding
I0048754biological_processbranching morphogenesis of an epithelial tube
I0050821biological_processprotein stabilization
I0051301biological_processcell division
I0060828biological_processregulation of canonical Wnt signaling pathway
I0070062cellular_componentextracellular exosome
I0072357cellular_componentPTW/PP1 phosphatase complex
I0097225cellular_componentsperm midpiece
I0097229cellular_componentsperm end piece
I0098609biological_processcell-cell adhesion
I0098641molecular_functioncadherin binding involved in cell-cell adhesion
I0098793cellular_componentpresynapse
I0098794cellular_componentpostsynapse
I0098978cellular_componentglutamatergic synapse
I0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
I2000806biological_processpositive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
I2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
L0000164cellular_componentprotein phosphatase type 1 complex
L0000781cellular_componentchromosome, telomeric region
L0001111biological_processRNA polymerase II promoter clearance
L0004721molecular_functionphosphoprotein phosphatase activity
L0004722molecular_functionprotein serine/threonine phosphatase activity
L0005506molecular_functioniron ion binding
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005730cellular_componentnucleolus
L0005737cellular_componentcytoplasm
L0005783cellular_componentendoplasmic reticulum
L0005814cellular_componentcentriole
L0005829cellular_componentcytosol
L0005886cellular_componentplasma membrane
L0005912cellular_componentadherens junction
L0005977biological_processglycogen metabolic process
L0005979biological_processregulation of glycogen biosynthetic process
L0005981biological_processregulation of glycogen catabolic process
L0006470biological_processprotein dephosphorylation
L0008157molecular_functionprotein phosphatase 1 binding
L0010288biological_processresponse to lead ion
L0016787molecular_functionhydrolase activity
L0016791molecular_functionphosphatase activity
L0030324biological_processlung development
L0032922biological_processcircadian regulation of gene expression
L0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
L0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
L0042587cellular_componentglycogen granule
L0042752biological_processregulation of circadian rhythm
L0043021molecular_functionribonucleoprotein complex binding
L0043025cellular_componentneuronal cell body
L0043153biological_processentrainment of circadian clock by photoperiod
L0043197cellular_componentdendritic spine
L0043204cellular_componentperikaryon
L0043247biological_processtelomere maintenance in response to DNA damage
L0043558biological_processregulation of translational initiation in response to stress
L0044877molecular_functionprotein-containing complex binding
L0045725biological_processpositive regulation of glycogen biosynthetic process
L0046872molecular_functionmetal ion binding
L0046914molecular_functiontransition metal ion binding
L0048754biological_processbranching morphogenesis of an epithelial tube
L0050821biological_processprotein stabilization
L0051301biological_processcell division
L0060828biological_processregulation of canonical Wnt signaling pathway
L0070062cellular_componentextracellular exosome
L0072357cellular_componentPTW/PP1 phosphatase complex
L0097225cellular_componentsperm midpiece
L0097229cellular_componentsperm end piece
L0098609biological_processcell-cell adhesion
L0098641molecular_functioncadherin binding involved in cell-cell adhesion
L0098793cellular_componentpresynapse
L0098794cellular_componentpostsynapse
L0098978cellular_componentglutamatergic synapse
L0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
L2000806biological_processpositive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
L2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
O0000164cellular_componentprotein phosphatase type 1 complex
O0000781cellular_componentchromosome, telomeric region
O0001111biological_processRNA polymerase II promoter clearance
O0004721molecular_functionphosphoprotein phosphatase activity
O0004722molecular_functionprotein serine/threonine phosphatase activity
O0005506molecular_functioniron ion binding
O0005515molecular_functionprotein binding
O0005634cellular_componentnucleus
O0005654cellular_componentnucleoplasm
O0005730cellular_componentnucleolus
O0005737cellular_componentcytoplasm
O0005783cellular_componentendoplasmic reticulum
O0005814cellular_componentcentriole
O0005829cellular_componentcytosol
O0005886cellular_componentplasma membrane
O0005912cellular_componentadherens junction
O0005977biological_processglycogen metabolic process
O0005979biological_processregulation of glycogen biosynthetic process
O0005981biological_processregulation of glycogen catabolic process
O0006470biological_processprotein dephosphorylation
O0008157molecular_functionprotein phosphatase 1 binding
O0010288biological_processresponse to lead ion
O0016787molecular_functionhydrolase activity
O0016791molecular_functionphosphatase activity
O0030324biological_processlung development
O0032922biological_processcircadian regulation of gene expression
O0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
O0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
O0042587cellular_componentglycogen granule
O0042752biological_processregulation of circadian rhythm
O0043021molecular_functionribonucleoprotein complex binding
O0043025cellular_componentneuronal cell body
O0043153biological_processentrainment of circadian clock by photoperiod
O0043197cellular_componentdendritic spine
O0043204cellular_componentperikaryon
O0043247biological_processtelomere maintenance in response to DNA damage
O0043558biological_processregulation of translational initiation in response to stress
O0044877molecular_functionprotein-containing complex binding
O0045725biological_processpositive regulation of glycogen biosynthetic process
O0046872molecular_functionmetal ion binding
O0046914molecular_functiontransition metal ion binding
O0048754biological_processbranching morphogenesis of an epithelial tube
O0050821biological_processprotein stabilization
O0051301biological_processcell division
O0060828biological_processregulation of canonical Wnt signaling pathway
O0070062cellular_componentextracellular exosome
O0072357cellular_componentPTW/PP1 phosphatase complex
O0097225cellular_componentsperm midpiece
O0097229cellular_componentsperm end piece
O0098609biological_processcell-cell adhesion
O0098641molecular_functioncadherin binding involved in cell-cell adhesion
O0098793cellular_componentpresynapse
O0098794cellular_componentpostsynapse
O0098978cellular_componentglutamatergic synapse
O0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
O2000806biological_processpositive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
O2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue MN D 401
ChainResidue
DASP91
DASN123
DHIS172
DHIS247
DMN402

site_idAC2
Number of Residues4
Detailsbinding site for residue MN D 402
ChainResidue
DASP63
DHIS65
DASP91
DMN401

site_idAC3
Number of Residues7
Detailsbinding site for residue GOL A 401
ChainResidue
AVAL194
APRO195
AASP196
ATRP205
AARG360
AHOH531
AHOH563

site_idAC4
Number of Residues8
Detailsbinding site for residue GOL A 402
ChainResidue
ALEU46
ASER47
AHOH510
AHOH515
AHOH532
OLEU46
OMET189
OARG190

site_idAC5
Number of Residues4
Detailsbinding site for residue EDO A 403
ChainResidue
ALYS140
AARG141
AARG142
ATYR143

site_idAC6
Number of Residues5
Detailsbinding site for residue MN A 404
ChainResidue
AASP91
AASN123
AHIS172
AHIS247
AMN405

site_idAC7
Number of Residues4
Detailsbinding site for residue MN A 405
ChainResidue
AASP63
AHIS65
AASP91
AMN404

site_idAC8
Number of Residues6
Detailsbinding site for residue GOL F 401
ChainResidue
FGLN19
FGLY20
FSER21
FARG73
FGLU76
FGLN316

site_idAC9
Number of Residues5
Detailsbinding site for residue MN F 402
ChainResidue
FASP91
FASN123
FHIS172
FHIS247
FMN403

site_idAD1
Number of Residues4
Detailsbinding site for residue MN F 403
ChainResidue
FASP63
FHIS65
FASP91
FMN402

site_idAD2
Number of Residues4
Detailsbinding site for residue GOL I 401
ChainResidue
ISER128
IILE129
IARG360
IHIS362

site_idAD3
Number of Residues5
Detailsbinding site for residue MN I 402
ChainResidue
IASP91
IASN123
IHIS172
IHIS247
IMN403

site_idAD4
Number of Residues4
Detailsbinding site for residue MN I 403
ChainResidue
IASP63
IHIS65
IASP91
IMN402

site_idAD5
Number of Residues6
Detailsbinding site for residue MN L 401
ChainResidue
LASP91
LASN123
LHIS172
LHIS247
LMN402
LHOH503

site_idAD6
Number of Residues5
Detailsbinding site for residue MN L 402
ChainResidue
LASP63
LHIS65
LASP91
LMN401
LHOH503

site_idAD7
Number of Residues5
Detailsbinding site for residue GOL O 401
ChainResidue
OARG131
OILE132
OASP137
OPRO325
OTRP326

site_idAD8
Number of Residues4
Detailsbinding site for residue GOL O 402
ChainResidue
AGLU353
OILE111
OLYS112
OGLN197

site_idAD9
Number of Residues6
Detailsbinding site for residue GOL O 403
ChainResidue
OVAL194
OPRO195
OTRP205
OVAL222
OARG360
OHOH549

site_idAE1
Number of Residues5
Detailsbinding site for residue MN O 404
ChainResidue
OASP91
OASN123
OHIS172
OHIS247
OMN405

site_idAE2
Number of Residues4
Detailsbinding site for residue MN O 405
ChainResidue
OMN404
OASP63
OHIS65
OASP91

Functional Information from PROSITE/UniProt
site_idPS00125
Number of Residues6
DetailsSER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
ChainResidueDetails
DLEU120-GLU125

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues36
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30100357","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35830882","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35831509","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36175670","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39446389","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UPI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SW5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues6
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

243531

PDB entries from 2025-10-22

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