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6ZEJ

Structure of PP1-Phactr1 chimera [PP1(7-304) + linker (SGSGS) + Phactr1(526-580)]

Functional Information from GO Data
ChainGOidnamespacecontents
A0000164cellular_componentprotein phosphatase type 1 complex
A0000723biological_processtelomere maintenance
A0000781cellular_componentchromosome, telomeric region
A0001111biological_processRNA polymerase II promoter clearance
A0004721molecular_functionphosphoprotein phosphatase activity
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0005506molecular_functioniron ion binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005912cellular_componentadherens junction
A0005977biological_processglycogen metabolic process
A0005979biological_processregulation of glycogen biosynthetic process
A0005981biological_processregulation of glycogen catabolic process
A0006366biological_processtranscription by RNA polymerase II
A0006368biological_processtranscription elongation by RNA polymerase II
A0006470biological_processprotein dephosphorylation
A0008157molecular_functionprotein phosphatase 1 binding
A0010288biological_processresponse to lead ion
A0016311biological_processdephosphorylation
A0016787molecular_functionhydrolase activity
A0016791molecular_functionphosphatase activity
A0030324biological_processlung development
A0032922biological_processcircadian regulation of gene expression
A0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
A0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
A0042587cellular_componentglycogen granule
A0042752biological_processregulation of circadian rhythm
A0043021molecular_functionribonucleoprotein complex binding
A0043025cellular_componentneuronal cell body
A0043153biological_processentrainment of circadian clock by photoperiod
A0043197cellular_componentdendritic spine
A0043204cellular_componentperikaryon
A0043247biological_processtelomere maintenance in response to DNA damage
A0043558biological_processregulation of translational initiation in response to stress
A0044877molecular_functionprotein-containing complex binding
A0045725biological_processpositive regulation of glycogen biosynthetic process
A0046872molecular_functionmetal ion binding
A0046914molecular_functiontransition metal ion binding
A0048754biological_processbranching morphogenesis of an epithelial tube
A0050821biological_processprotein stabilization
A0051301biological_processcell division
A0060828biological_processregulation of canonical Wnt signaling pathway
A0070062cellular_componentextracellular exosome
A0072357cellular_componentPTW/PP1 phosphatase complex
A0097681biological_processdouble-strand break repair via alternative nonhomologous end joining
A0098609biological_processcell-cell adhesion
A0098641molecular_functioncadherin binding involved in cell-cell adhesion
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
A2000806biological_processpositive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
A2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
D0000164cellular_componentprotein phosphatase type 1 complex
D0000723biological_processtelomere maintenance
D0000781cellular_componentchromosome, telomeric region
D0001111biological_processRNA polymerase II promoter clearance
D0004721molecular_functionphosphoprotein phosphatase activity
D0004722molecular_functionprotein serine/threonine phosphatase activity
D0005506molecular_functioniron ion binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005912cellular_componentadherens junction
D0005977biological_processglycogen metabolic process
D0005979biological_processregulation of glycogen biosynthetic process
D0005981biological_processregulation of glycogen catabolic process
D0006366biological_processtranscription by RNA polymerase II
D0006368biological_processtranscription elongation by RNA polymerase II
D0006470biological_processprotein dephosphorylation
D0008157molecular_functionprotein phosphatase 1 binding
D0010288biological_processresponse to lead ion
D0016311biological_processdephosphorylation
D0016787molecular_functionhydrolase activity
D0016791molecular_functionphosphatase activity
D0030324biological_processlung development
D0032922biological_processcircadian regulation of gene expression
D0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
D0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
D0042587cellular_componentglycogen granule
D0042752biological_processregulation of circadian rhythm
D0043021molecular_functionribonucleoprotein complex binding
D0043025cellular_componentneuronal cell body
D0043153biological_processentrainment of circadian clock by photoperiod
D0043197cellular_componentdendritic spine
D0043204cellular_componentperikaryon
D0043247biological_processtelomere maintenance in response to DNA damage
D0043558biological_processregulation of translational initiation in response to stress
D0044877molecular_functionprotein-containing complex binding
D0045725biological_processpositive regulation of glycogen biosynthetic process
D0046872molecular_functionmetal ion binding
D0046914molecular_functiontransition metal ion binding
D0048754biological_processbranching morphogenesis of an epithelial tube
D0050821biological_processprotein stabilization
D0051301biological_processcell division
D0060828biological_processregulation of canonical Wnt signaling pathway
D0070062cellular_componentextracellular exosome
D0072357cellular_componentPTW/PP1 phosphatase complex
D0097681biological_processdouble-strand break repair via alternative nonhomologous end joining
D0098609biological_processcell-cell adhesion
D0098641molecular_functioncadherin binding involved in cell-cell adhesion
D0098793cellular_componentpresynapse
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
D2000806biological_processpositive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
D2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
F0000164cellular_componentprotein phosphatase type 1 complex
F0000723biological_processtelomere maintenance
F0000781cellular_componentchromosome, telomeric region
F0001111biological_processRNA polymerase II promoter clearance
F0004721molecular_functionphosphoprotein phosphatase activity
F0004722molecular_functionprotein serine/threonine phosphatase activity
F0005506molecular_functioniron ion binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0005912cellular_componentadherens junction
F0005977biological_processglycogen metabolic process
F0005979biological_processregulation of glycogen biosynthetic process
F0005981biological_processregulation of glycogen catabolic process
F0006366biological_processtranscription by RNA polymerase II
F0006368biological_processtranscription elongation by RNA polymerase II
F0006470biological_processprotein dephosphorylation
F0008157molecular_functionprotein phosphatase 1 binding
F0010288biological_processresponse to lead ion
F0016311biological_processdephosphorylation
F0016787molecular_functionhydrolase activity
F0016791molecular_functionphosphatase activity
F0030324biological_processlung development
F0032922biological_processcircadian regulation of gene expression
F0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
F0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
F0042587cellular_componentglycogen granule
F0042752biological_processregulation of circadian rhythm
F0043021molecular_functionribonucleoprotein complex binding
F0043025cellular_componentneuronal cell body
F0043153biological_processentrainment of circadian clock by photoperiod
F0043197cellular_componentdendritic spine
F0043204cellular_componentperikaryon
F0043247biological_processtelomere maintenance in response to DNA damage
F0043558biological_processregulation of translational initiation in response to stress
F0044877molecular_functionprotein-containing complex binding
F0045725biological_processpositive regulation of glycogen biosynthetic process
F0046872molecular_functionmetal ion binding
F0046914molecular_functiontransition metal ion binding
F0048754biological_processbranching morphogenesis of an epithelial tube
F0050821biological_processprotein stabilization
F0051301biological_processcell division
F0060828biological_processregulation of canonical Wnt signaling pathway
F0070062cellular_componentextracellular exosome
F0072357cellular_componentPTW/PP1 phosphatase complex
F0097681biological_processdouble-strand break repair via alternative nonhomologous end joining
F0098609biological_processcell-cell adhesion
F0098641molecular_functioncadherin binding involved in cell-cell adhesion
F0098793cellular_componentpresynapse
F0098794cellular_componentpostsynapse
F0098978cellular_componentglutamatergic synapse
F0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
F2000806biological_processpositive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
F2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
I0000164cellular_componentprotein phosphatase type 1 complex
I0000723biological_processtelomere maintenance
I0000781cellular_componentchromosome, telomeric region
I0001111biological_processRNA polymerase II promoter clearance
I0004721molecular_functionphosphoprotein phosphatase activity
I0004722molecular_functionprotein serine/threonine phosphatase activity
I0005506molecular_functioniron ion binding
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005730cellular_componentnucleolus
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0005886cellular_componentplasma membrane
I0005912cellular_componentadherens junction
I0005977biological_processglycogen metabolic process
I0005979biological_processregulation of glycogen biosynthetic process
I0005981biological_processregulation of glycogen catabolic process
I0006366biological_processtranscription by RNA polymerase II
I0006368biological_processtranscription elongation by RNA polymerase II
I0006470biological_processprotein dephosphorylation
I0008157molecular_functionprotein phosphatase 1 binding
I0010288biological_processresponse to lead ion
I0016311biological_processdephosphorylation
I0016787molecular_functionhydrolase activity
I0016791molecular_functionphosphatase activity
I0030324biological_processlung development
I0032922biological_processcircadian regulation of gene expression
I0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
I0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
I0042587cellular_componentglycogen granule
I0042752biological_processregulation of circadian rhythm
I0043021molecular_functionribonucleoprotein complex binding
I0043025cellular_componentneuronal cell body
I0043153biological_processentrainment of circadian clock by photoperiod
I0043197cellular_componentdendritic spine
I0043204cellular_componentperikaryon
I0043247biological_processtelomere maintenance in response to DNA damage
I0043558biological_processregulation of translational initiation in response to stress
I0044877molecular_functionprotein-containing complex binding
I0045725biological_processpositive regulation of glycogen biosynthetic process
I0046872molecular_functionmetal ion binding
I0046914molecular_functiontransition metal ion binding
I0048754biological_processbranching morphogenesis of an epithelial tube
I0050821biological_processprotein stabilization
I0051301biological_processcell division
I0060828biological_processregulation of canonical Wnt signaling pathway
I0070062cellular_componentextracellular exosome
I0072357cellular_componentPTW/PP1 phosphatase complex
I0097681biological_processdouble-strand break repair via alternative nonhomologous end joining
I0098609biological_processcell-cell adhesion
I0098641molecular_functioncadherin binding involved in cell-cell adhesion
I0098793cellular_componentpresynapse
I0098794cellular_componentpostsynapse
I0098978cellular_componentglutamatergic synapse
I0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
I2000806biological_processpositive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
I2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
L0000164cellular_componentprotein phosphatase type 1 complex
L0000723biological_processtelomere maintenance
L0000781cellular_componentchromosome, telomeric region
L0001111biological_processRNA polymerase II promoter clearance
L0004721molecular_functionphosphoprotein phosphatase activity
L0004722molecular_functionprotein serine/threonine phosphatase activity
L0005506molecular_functioniron ion binding
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005730cellular_componentnucleolus
L0005737cellular_componentcytoplasm
L0005829cellular_componentcytosol
L0005886cellular_componentplasma membrane
L0005912cellular_componentadherens junction
L0005977biological_processglycogen metabolic process
L0005979biological_processregulation of glycogen biosynthetic process
L0005981biological_processregulation of glycogen catabolic process
L0006366biological_processtranscription by RNA polymerase II
L0006368biological_processtranscription elongation by RNA polymerase II
L0006470biological_processprotein dephosphorylation
L0008157molecular_functionprotein phosphatase 1 binding
L0010288biological_processresponse to lead ion
L0016311biological_processdephosphorylation
L0016787molecular_functionhydrolase activity
L0016791molecular_functionphosphatase activity
L0030324biological_processlung development
L0032922biological_processcircadian regulation of gene expression
L0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
L0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
L0042587cellular_componentglycogen granule
L0042752biological_processregulation of circadian rhythm
L0043021molecular_functionribonucleoprotein complex binding
L0043025cellular_componentneuronal cell body
L0043153biological_processentrainment of circadian clock by photoperiod
L0043197cellular_componentdendritic spine
L0043204cellular_componentperikaryon
L0043247biological_processtelomere maintenance in response to DNA damage
L0043558biological_processregulation of translational initiation in response to stress
L0044877molecular_functionprotein-containing complex binding
L0045725biological_processpositive regulation of glycogen biosynthetic process
L0046872molecular_functionmetal ion binding
L0046914molecular_functiontransition metal ion binding
L0048754biological_processbranching morphogenesis of an epithelial tube
L0050821biological_processprotein stabilization
L0051301biological_processcell division
L0060828biological_processregulation of canonical Wnt signaling pathway
L0070062cellular_componentextracellular exosome
L0072357cellular_componentPTW/PP1 phosphatase complex
L0097681biological_processdouble-strand break repair via alternative nonhomologous end joining
L0098609biological_processcell-cell adhesion
L0098641molecular_functioncadherin binding involved in cell-cell adhesion
L0098793cellular_componentpresynapse
L0098794cellular_componentpostsynapse
L0098978cellular_componentglutamatergic synapse
L0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
L2000806biological_processpositive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
L2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
O0000164cellular_componentprotein phosphatase type 1 complex
O0000723biological_processtelomere maintenance
O0000781cellular_componentchromosome, telomeric region
O0001111biological_processRNA polymerase II promoter clearance
O0004721molecular_functionphosphoprotein phosphatase activity
O0004722molecular_functionprotein serine/threonine phosphatase activity
O0005506molecular_functioniron ion binding
O0005515molecular_functionprotein binding
O0005634cellular_componentnucleus
O0005654cellular_componentnucleoplasm
O0005730cellular_componentnucleolus
O0005737cellular_componentcytoplasm
O0005829cellular_componentcytosol
O0005886cellular_componentplasma membrane
O0005912cellular_componentadherens junction
O0005977biological_processglycogen metabolic process
O0005979biological_processregulation of glycogen biosynthetic process
O0005981biological_processregulation of glycogen catabolic process
O0006366biological_processtranscription by RNA polymerase II
O0006368biological_processtranscription elongation by RNA polymerase II
O0006470biological_processprotein dephosphorylation
O0008157molecular_functionprotein phosphatase 1 binding
O0010288biological_processresponse to lead ion
O0016311biological_processdephosphorylation
O0016787molecular_functionhydrolase activity
O0016791molecular_functionphosphatase activity
O0030324biological_processlung development
O0032922biological_processcircadian regulation of gene expression
O0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
O0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
O0042587cellular_componentglycogen granule
O0042752biological_processregulation of circadian rhythm
O0043021molecular_functionribonucleoprotein complex binding
O0043025cellular_componentneuronal cell body
O0043153biological_processentrainment of circadian clock by photoperiod
O0043197cellular_componentdendritic spine
O0043204cellular_componentperikaryon
O0043247biological_processtelomere maintenance in response to DNA damage
O0043558biological_processregulation of translational initiation in response to stress
O0044877molecular_functionprotein-containing complex binding
O0045725biological_processpositive regulation of glycogen biosynthetic process
O0046872molecular_functionmetal ion binding
O0046914molecular_functiontransition metal ion binding
O0048754biological_processbranching morphogenesis of an epithelial tube
O0050821biological_processprotein stabilization
O0051301biological_processcell division
O0060828biological_processregulation of canonical Wnt signaling pathway
O0070062cellular_componentextracellular exosome
O0072357cellular_componentPTW/PP1 phosphatase complex
O0097681biological_processdouble-strand break repair via alternative nonhomologous end joining
O0098609biological_processcell-cell adhesion
O0098641molecular_functioncadherin binding involved in cell-cell adhesion
O0098793cellular_componentpresynapse
O0098794cellular_componentpostsynapse
O0098978cellular_componentglutamatergic synapse
O0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
O2000806biological_processpositive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
O2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue MN D 401
ChainResidue
DASP91
DASN123
DHIS172
DHIS247
DMN402

site_idAC2
Number of Residues4
Detailsbinding site for residue MN D 402
ChainResidue
DASP63
DHIS65
DASP91
DMN401

site_idAC3
Number of Residues7
Detailsbinding site for residue GOL A 401
ChainResidue
AVAL194
APRO195
AASP196
ATRP205
AARG360
AHOH531
AHOH563

site_idAC4
Number of Residues8
Detailsbinding site for residue GOL A 402
ChainResidue
ALEU46
ASER47
AHOH510
AHOH515
AHOH532
OLEU46
OMET189
OARG190

site_idAC5
Number of Residues4
Detailsbinding site for residue EDO A 403
ChainResidue
ALYS140
AARG141
AARG142
ATYR143

site_idAC6
Number of Residues5
Detailsbinding site for residue MN A 404
ChainResidue
AASP91
AASN123
AHIS172
AHIS247
AMN405

site_idAC7
Number of Residues4
Detailsbinding site for residue MN A 405
ChainResidue
AASP63
AHIS65
AASP91
AMN404

site_idAC8
Number of Residues6
Detailsbinding site for residue GOL F 401
ChainResidue
FGLN19
FGLY20
FSER21
FARG73
FGLU76
FGLN316

site_idAC9
Number of Residues5
Detailsbinding site for residue MN F 402
ChainResidue
FASP91
FASN123
FHIS172
FHIS247
FMN403

site_idAD1
Number of Residues4
Detailsbinding site for residue MN F 403
ChainResidue
FASP63
FHIS65
FASP91
FMN402

site_idAD2
Number of Residues4
Detailsbinding site for residue GOL I 401
ChainResidue
ISER128
IILE129
IARG360
IHIS362

site_idAD3
Number of Residues5
Detailsbinding site for residue MN I 402
ChainResidue
IASP91
IASN123
IHIS172
IHIS247
IMN403

site_idAD4
Number of Residues4
Detailsbinding site for residue MN I 403
ChainResidue
IASP63
IHIS65
IASP91
IMN402

site_idAD5
Number of Residues6
Detailsbinding site for residue MN L 401
ChainResidue
LASP91
LASN123
LHIS172
LHIS247
LMN402
LHOH503

site_idAD6
Number of Residues5
Detailsbinding site for residue MN L 402
ChainResidue
LASP63
LHIS65
LASP91
LMN401
LHOH503

site_idAD7
Number of Residues5
Detailsbinding site for residue GOL O 401
ChainResidue
OARG131
OILE132
OASP137
OPRO325
OTRP326

site_idAD8
Number of Residues4
Detailsbinding site for residue GOL O 402
ChainResidue
AGLU353
OILE111
OLYS112
OGLN197

site_idAD9
Number of Residues6
Detailsbinding site for residue GOL O 403
ChainResidue
OVAL194
OPRO195
OTRP205
OVAL222
OARG360
OHOH549

site_idAE1
Number of Residues5
Detailsbinding site for residue MN O 404
ChainResidue
OASP91
OASN123
OHIS172
OHIS247
OMN405

site_idAE2
Number of Residues4
Detailsbinding site for residue MN O 405
ChainResidue
OMN404
OASP63
OHIS65
OASP91

Functional Information from PROSITE/UniProt
site_idPS00125
Number of Residues6
DetailsSER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
ChainResidueDetails
DLEU120-GLU125

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:P36873
ChainResidueDetails
DHIS124
AHIS124
FHIS124
IHIS124
LHIS124
OHIS124

site_idSWS_FT_FI2
Number of Residues36
DetailsBINDING: BINDING => ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0007744|PDB:6CZO, ECO:0007744|PDB:7TVF, ECO:0007744|PDB:7TXH, ECO:0007744|PDB:7UPI
ChainResidueDetails
DASP63
AASN123
AHIS172
AHIS247
FASP63
FHIS65
FASP91
FASN123
FHIS172
FHIS247
IASP63
DHIS65
IHIS65
IASP91
IASN123
IHIS172
IHIS247
LASP63
LHIS65
LASP91
LASN123
LHIS172
DASP91
LHIS247
OASP63
OHIS65
OASP91
OASN123
OHIS172
OHIS247
DASN123
DHIS172
DHIS247
AASP63
AHIS65
AASP91

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER21
ASER21
FSER21
ISER21
LSER21
OSER21

237735

PDB entries from 2025-06-18

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