6ZEJ

Structure of PP1-Phactr1 chimera [PP1(7-304) + linker (SGSGS) + Phactr1(526-580)]

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000164	cellular_component	protein phosphatase type 1 complex
A	0000781	cellular_component	chromosome, telomeric region
A	0001111	biological_process	RNA polymerase II promoter clearance
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0005912	cellular_component	adherens junction
A	0005977	biological_process	glycogen metabolic process
A	0005979	biological_process	regulation of glycogen biosynthetic process
A	0005981	biological_process	regulation of glycogen catabolic process
A	0006470	biological_process	protein dephosphorylation
A	0008157	molecular_function	protein phosphatase 1 binding
A	0010288	biological_process	response to lead ion
A	0016787	molecular_function	hydrolase activity
A	0016791	molecular_function	phosphatase activity
A	0032922	biological_process	circadian regulation of gene expression
A	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
A	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
A	0042587	cellular_component	glycogen granule
A	0042752	biological_process	regulation of circadian rhythm
A	0043021	molecular_function	ribonucleoprotein complex binding
A	0043025	cellular_component	neuronal cell body
A	0043153	biological_process	entrainment of circadian clock by photoperiod
A	0043197	cellular_component	dendritic spine
A	0043204	cellular_component	perikaryon
A	0043247	biological_process	telomere maintenance in response to DNA damage
A	0043558	biological_process	regulation of translational initiation in response to stress
A	0044877	molecular_function	protein-containing complex binding
A	0045725	biological_process	positive regulation of glycogen biosynthetic process
A	0046579	biological_process	positive regulation of Ras protein signal transduction
A	0046872	molecular_function	metal ion binding
A	0046914	molecular_function	transition metal ion binding
A	0050821	biological_process	protein stabilization
A	0051301	biological_process	cell division
A	0060828	biological_process	regulation of canonical Wnt signaling pathway
A	0070062	cellular_component	extracellular exosome
A	0072357	cellular_component	PTW/PP1 phosphatase complex
A	0098609	biological_process	cell-cell adhesion
A	0098641	molecular_function	cadherin binding involved in cell-cell adhesion
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
A	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
A	2000806	biological_process	positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
D	0000164	cellular_component	protein phosphatase type 1 complex
D	0000781	cellular_component	chromosome, telomeric region
D	0001111	biological_process	RNA polymerase II promoter clearance
D	0004721	molecular_function	phosphoprotein phosphatase activity
D	0004722	molecular_function	protein serine/threonine phosphatase activity
D	0005506	molecular_function	iron ion binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005829	cellular_component	cytosol
D	0005912	cellular_component	adherens junction
D	0005977	biological_process	glycogen metabolic process
D	0005979	biological_process	regulation of glycogen biosynthetic process
D	0005981	biological_process	regulation of glycogen catabolic process
D	0006470	biological_process	protein dephosphorylation
D	0008157	molecular_function	protein phosphatase 1 binding
D	0010288	biological_process	response to lead ion
D	0016787	molecular_function	hydrolase activity
D	0016791	molecular_function	phosphatase activity
D	0032922	biological_process	circadian regulation of gene expression
D	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
D	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
D	0042587	cellular_component	glycogen granule
D	0042752	biological_process	regulation of circadian rhythm
D	0043021	molecular_function	ribonucleoprotein complex binding
D	0043025	cellular_component	neuronal cell body
D	0043153	biological_process	entrainment of circadian clock by photoperiod
D	0043197	cellular_component	dendritic spine
D	0043204	cellular_component	perikaryon
D	0043247	biological_process	telomere maintenance in response to DNA damage
D	0043558	biological_process	regulation of translational initiation in response to stress
D	0044877	molecular_function	protein-containing complex binding
D	0045725	biological_process	positive regulation of glycogen biosynthetic process
D	0046579	biological_process	positive regulation of Ras protein signal transduction
D	0046872	molecular_function	metal ion binding
D	0046914	molecular_function	transition metal ion binding
D	0050821	biological_process	protein stabilization
D	0051301	biological_process	cell division
D	0060828	biological_process	regulation of canonical Wnt signaling pathway
D	0070062	cellular_component	extracellular exosome
D	0072357	cellular_component	PTW/PP1 phosphatase complex
D	0098609	biological_process	cell-cell adhesion
D	0098641	molecular_function	cadherin binding involved in cell-cell adhesion
D	0098793	cellular_component	presynapse
D	0098794	cellular_component	postsynapse
D	0098978	cellular_component	glutamatergic synapse
D	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
D	2000806	biological_process	positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
F	0000164	cellular_component	protein phosphatase type 1 complex
F	0000781	cellular_component	chromosome, telomeric region
F	0001111	biological_process	RNA polymerase II promoter clearance
F	0004721	molecular_function	phosphoprotein phosphatase activity
F	0004722	molecular_function	protein serine/threonine phosphatase activity
F	0005506	molecular_function	iron ion binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005730	cellular_component	nucleolus
F	0005737	cellular_component	cytoplasm
F	0005783	cellular_component	endoplasmic reticulum
F	0005829	cellular_component	cytosol
F	0005912	cellular_component	adherens junction
F	0005977	biological_process	glycogen metabolic process
F	0005979	biological_process	regulation of glycogen biosynthetic process
F	0005981	biological_process	regulation of glycogen catabolic process
F	0006470	biological_process	protein dephosphorylation
F	0008157	molecular_function	protein phosphatase 1 binding
F	0010288	biological_process	response to lead ion
F	0016787	molecular_function	hydrolase activity
F	0016791	molecular_function	phosphatase activity
F	0032922	biological_process	circadian regulation of gene expression
F	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
F	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
F	0042587	cellular_component	glycogen granule
F	0042752	biological_process	regulation of circadian rhythm
F	0043021	molecular_function	ribonucleoprotein complex binding
F	0043025	cellular_component	neuronal cell body
F	0043153	biological_process	entrainment of circadian clock by photoperiod
F	0043197	cellular_component	dendritic spine
F	0043204	cellular_component	perikaryon
F	0043247	biological_process	telomere maintenance in response to DNA damage
F	0043558	biological_process	regulation of translational initiation in response to stress
F	0044877	molecular_function	protein-containing complex binding
F	0045725	biological_process	positive regulation of glycogen biosynthetic process
F	0046579	biological_process	positive regulation of Ras protein signal transduction
F	0046872	molecular_function	metal ion binding
F	0046914	molecular_function	transition metal ion binding
F	0050821	biological_process	protein stabilization
F	0051301	biological_process	cell division
F	0060828	biological_process	regulation of canonical Wnt signaling pathway
F	0070062	cellular_component	extracellular exosome
F	0072357	cellular_component	PTW/PP1 phosphatase complex
F	0098609	biological_process	cell-cell adhesion
F	0098641	molecular_function	cadherin binding involved in cell-cell adhesion
F	0098793	cellular_component	presynapse
F	0098794	cellular_component	postsynapse
F	0098978	cellular_component	glutamatergic synapse
F	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
F	2000806	biological_process	positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
I	0000164	cellular_component	protein phosphatase type 1 complex
I	0000781	cellular_component	chromosome, telomeric region
I	0001111	biological_process	RNA polymerase II promoter clearance
I	0004721	molecular_function	phosphoprotein phosphatase activity
I	0004722	molecular_function	protein serine/threonine phosphatase activity
I	0005506	molecular_function	iron ion binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005730	cellular_component	nucleolus
I	0005737	cellular_component	cytoplasm
I	0005783	cellular_component	endoplasmic reticulum
I	0005829	cellular_component	cytosol
I	0005912	cellular_component	adherens junction
I	0005977	biological_process	glycogen metabolic process
I	0005979	biological_process	regulation of glycogen biosynthetic process
I	0005981	biological_process	regulation of glycogen catabolic process
I	0006470	biological_process	protein dephosphorylation
I	0008157	molecular_function	protein phosphatase 1 binding
I	0010288	biological_process	response to lead ion
I	0016787	molecular_function	hydrolase activity
I	0016791	molecular_function	phosphatase activity
I	0032922	biological_process	circadian regulation of gene expression
I	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
I	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
I	0042587	cellular_component	glycogen granule
I	0042752	biological_process	regulation of circadian rhythm
I	0043021	molecular_function	ribonucleoprotein complex binding
I	0043025	cellular_component	neuronal cell body
I	0043153	biological_process	entrainment of circadian clock by photoperiod
I	0043197	cellular_component	dendritic spine
I	0043204	cellular_component	perikaryon
I	0043247	biological_process	telomere maintenance in response to DNA damage
I	0043558	biological_process	regulation of translational initiation in response to stress
I	0044877	molecular_function	protein-containing complex binding
I	0045725	biological_process	positive regulation of glycogen biosynthetic process
I	0046579	biological_process	positive regulation of Ras protein signal transduction
I	0046872	molecular_function	metal ion binding
I	0046914	molecular_function	transition metal ion binding
I	0050821	biological_process	protein stabilization
I	0051301	biological_process	cell division
I	0060828	biological_process	regulation of canonical Wnt signaling pathway
I	0070062	cellular_component	extracellular exosome
I	0072357	cellular_component	PTW/PP1 phosphatase complex
I	0098609	biological_process	cell-cell adhesion
I	0098641	molecular_function	cadherin binding involved in cell-cell adhesion
I	0098793	cellular_component	presynapse
I	0098794	cellular_component	postsynapse
I	0098978	cellular_component	glutamatergic synapse
I	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
I	2000806	biological_process	positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
L	0000164	cellular_component	protein phosphatase type 1 complex
L	0000781	cellular_component	chromosome, telomeric region
L	0001111	biological_process	RNA polymerase II promoter clearance
L	0004721	molecular_function	phosphoprotein phosphatase activity
L	0004722	molecular_function	protein serine/threonine phosphatase activity
L	0005506	molecular_function	iron ion binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005730	cellular_component	nucleolus
L	0005737	cellular_component	cytoplasm
L	0005783	cellular_component	endoplasmic reticulum
L	0005829	cellular_component	cytosol
L	0005912	cellular_component	adherens junction
L	0005977	biological_process	glycogen metabolic process
L	0005979	biological_process	regulation of glycogen biosynthetic process
L	0005981	biological_process	regulation of glycogen catabolic process
L	0006470	biological_process	protein dephosphorylation
L	0008157	molecular_function	protein phosphatase 1 binding
L	0010288	biological_process	response to lead ion
L	0016787	molecular_function	hydrolase activity
L	0016791	molecular_function	phosphatase activity
L	0032922	biological_process	circadian regulation of gene expression
L	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
L	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
L	0042587	cellular_component	glycogen granule
L	0042752	biological_process	regulation of circadian rhythm
L	0043021	molecular_function	ribonucleoprotein complex binding
L	0043025	cellular_component	neuronal cell body
L	0043153	biological_process	entrainment of circadian clock by photoperiod
L	0043197	cellular_component	dendritic spine
L	0043204	cellular_component	perikaryon
L	0043247	biological_process	telomere maintenance in response to DNA damage
L	0043558	biological_process	regulation of translational initiation in response to stress
L	0044877	molecular_function	protein-containing complex binding
L	0045725	biological_process	positive regulation of glycogen biosynthetic process
L	0046579	biological_process	positive regulation of Ras protein signal transduction
L	0046872	molecular_function	metal ion binding
L	0046914	molecular_function	transition metal ion binding
L	0050821	biological_process	protein stabilization
L	0051301	biological_process	cell division
L	0060828	biological_process	regulation of canonical Wnt signaling pathway
L	0070062	cellular_component	extracellular exosome
L	0072357	cellular_component	PTW/PP1 phosphatase complex
L	0098609	biological_process	cell-cell adhesion
L	0098641	molecular_function	cadherin binding involved in cell-cell adhesion
L	0098793	cellular_component	presynapse
L	0098794	cellular_component	postsynapse
L	0098978	cellular_component	glutamatergic synapse
L	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
L	2000806	biological_process	positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
O	0000164	cellular_component	protein phosphatase type 1 complex
O	0000781	cellular_component	chromosome, telomeric region
O	0001111	biological_process	RNA polymerase II promoter clearance
O	0004721	molecular_function	phosphoprotein phosphatase activity
O	0004722	molecular_function	protein serine/threonine phosphatase activity
O	0005506	molecular_function	iron ion binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005730	cellular_component	nucleolus
O	0005737	cellular_component	cytoplasm
O	0005783	cellular_component	endoplasmic reticulum
O	0005829	cellular_component	cytosol
O	0005912	cellular_component	adherens junction
O	0005977	biological_process	glycogen metabolic process
O	0005979	biological_process	regulation of glycogen biosynthetic process
O	0005981	biological_process	regulation of glycogen catabolic process
O	0006470	biological_process	protein dephosphorylation
O	0008157	molecular_function	protein phosphatase 1 binding
O	0010288	biological_process	response to lead ion
O	0016787	molecular_function	hydrolase activity
O	0016791	molecular_function	phosphatase activity
O	0032922	biological_process	circadian regulation of gene expression
O	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
O	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
O	0042587	cellular_component	glycogen granule
O	0042752	biological_process	regulation of circadian rhythm
O	0043021	molecular_function	ribonucleoprotein complex binding
O	0043025	cellular_component	neuronal cell body
O	0043153	biological_process	entrainment of circadian clock by photoperiod
O	0043197	cellular_component	dendritic spine
O	0043204	cellular_component	perikaryon
O	0043247	biological_process	telomere maintenance in response to DNA damage
O	0043558	biological_process	regulation of translational initiation in response to stress
O	0044877	molecular_function	protein-containing complex binding
O	0045725	biological_process	positive regulation of glycogen biosynthetic process
O	0046579	biological_process	positive regulation of Ras protein signal transduction
O	0046872	molecular_function	metal ion binding
O	0046914	molecular_function	transition metal ion binding
O	0050821	biological_process	protein stabilization
O	0051301	biological_process	cell division
O	0060828	biological_process	regulation of canonical Wnt signaling pathway
O	0070062	cellular_component	extracellular exosome
O	0072357	cellular_component	PTW/PP1 phosphatase complex
O	0098609	biological_process	cell-cell adhesion
O	0098641	molecular_function	cadherin binding involved in cell-cell adhesion
O	0098793	cellular_component	presynapse
O	0098794	cellular_component	postsynapse
O	0098978	cellular_component	glutamatergic synapse
O	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
O	2000806	biological_process	positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MN D 401

Chain	Residue
D	ASP91
D	ASN123
D	HIS172
D	HIS247
D	MN402

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MN D 402

Chain	Residue
D	ASP63
D	HIS65
D	ASP91
D	MN401

---

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL A 401

Chain	Residue
A	VAL194
A	PRO195
A	ASP196
A	TRP205
A	ARG360
A	HOH531
A	HOH563

---

site_id	AC4
Number of Residues	8
Details	binding site for residue GOL A 402

Chain	Residue
A	LEU46
A	SER47
A	HOH510
A	HOH515
A	HOH532
O	LEU46
O	MET189
O	ARG190

---

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO A 403

Chain	Residue
A	LYS140
A	ARG141
A	ARG142
A	TYR143

---

site_id	AC6
Number of Residues	5
Details	binding site for residue MN A 404

Chain	Residue
A	ASP91
A	ASN123
A	HIS172
A	HIS247
A	MN405

---

site_id	AC7
Number of Residues	4
Details	binding site for residue MN A 405

Chain	Residue
A	ASP63
A	HIS65
A	ASP91
A	MN404

---

site_id	AC8
Number of Residues	6
Details	binding site for residue GOL F 401

Chain	Residue
F	GLN19
F	GLY20
F	SER21
F	ARG73
F	GLU76
F	GLN316

---

site_id	AC9
Number of Residues	5
Details	binding site for residue MN F 402

Chain	Residue
F	ASP91
F	ASN123
F	HIS172
F	HIS247
F	MN403

---

site_id	AD1
Number of Residues	4
Details	binding site for residue MN F 403

Chain	Residue
F	ASP63
F	HIS65
F	ASP91
F	MN402

---

site_id	AD2
Number of Residues	4
Details	binding site for residue GOL I 401

Chain	Residue
I	SER128
I	ILE129
I	ARG360
I	HIS362

---

site_id	AD3
Number of Residues	5
Details	binding site for residue MN I 402

Chain	Residue
I	ASP91
I	ASN123
I	HIS172
I	HIS247
I	MN403

---

site_id	AD4
Number of Residues	4
Details	binding site for residue MN I 403

Chain	Residue
I	ASP63
I	HIS65
I	ASP91
I	MN402

---

site_id	AD5
Number of Residues	6
Details	binding site for residue MN L 401

Chain	Residue
L	ASP91
L	ASN123
L	HIS172
L	HIS247
L	MN402
L	HOH503

---

site_id	AD6
Number of Residues	5
Details	binding site for residue MN L 402

Chain	Residue
L	ASP63
L	HIS65
L	ASP91
L	MN401
L	HOH503

---

site_id	AD7
Number of Residues	5
Details	binding site for residue GOL O 401

Chain	Residue
O	ARG131
O	ILE132
O	ASP137
O	PRO325
O	TRP326

---

site_id	AD8
Number of Residues	4
Details	binding site for residue GOL O 402

Chain	Residue
A	GLU353
O	ILE111
O	LYS112
O	GLN197

---

site_id	AD9
Number of Residues	6
Details	binding site for residue GOL O 403

Chain	Residue
O	VAL194
O	PRO195
O	TRP205
O	VAL222
O	ARG360
O	HOH549

---

site_id	AE1
Number of Residues	5
Details	binding site for residue MN O 404

Chain	Residue
O	ASP91
O	ASN123
O	HIS172
O	HIS247
O	MN405

---

site_id	AE2
Number of Residues	4
Details	binding site for residue MN O 405

Chain	Residue
O	MN404
O	ASP63
O	HIS65
O	ASP91

---

Functional Information from PROSITE/UniProt

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
D	LEU120-GLU125

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30100357","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35830882","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35831509","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36175670","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39446389","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UPI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SW5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---