6ZDY

Crystal structure of WT murine S100A9 bound to calcium and zinc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001533	cellular_component	cornified envelope
A	0002376	biological_process	immune system process
A	0002523	biological_process	leukocyte migration involved in inflammatory response
A	0002544	biological_process	chronic inflammatory response
A	0002793	biological_process	positive regulation of peptide secretion
A	0005509	molecular_function	calcium ion binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0006417	biological_process	regulation of translation
A	0006914	biological_process	autophagy
A	0006915	biological_process	apoptotic process
A	0006935	biological_process	chemotaxis
A	0006954	biological_process	inflammatory response
A	0010976	biological_process	positive regulation of neuron projection development
A	0014002	biological_process	astrocyte development
A	0016209	molecular_function	antioxidant activity
A	0018119	biological_process	peptidyl-cysteine S-nitrosylation
A	0030036	biological_process	actin cytoskeleton organization
A	0030194	biological_process	positive regulation of blood coagulation
A	0030593	biological_process	neutrophil chemotaxis
A	0030595	biological_process	leukocyte chemotaxis
A	0034121	biological_process	regulation of toll-like receptor signaling pathway
A	0035425	biological_process	autocrine signaling
A	0035606	biological_process	peptidyl-cysteine S-trans-nitrosylation
A	0043542	biological_process	endothelial cell migration
A	0045087	biological_process	innate immune response
A	0045111	cellular_component	intermediate filament cytoskeleton
A	0045113	biological_process	regulation of integrin biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0050729	biological_process	positive regulation of inflammatory response
A	0060264	biological_process	regulation of respiratory burst involved in inflammatory response
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
A	0070488	biological_process	neutrophil aggregation
A	0098869	biological_process	cellular oxidant detoxification
A	1990660	cellular_component	calprotectin complex
A	1990662	cellular_component	S100A9 complex
A	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA A 201

Chain	Residue
A	SER24
A	GLU27
A	HIS29
A	THR32
A	GLU37
A	HOH355

---

site_id	AC2
Number of Residues	6
Details	binding site for residue CA A 202

Chain	Residue
A	GLN74
A	GLU79
A	HOH356
A	ASP68
A	ASN70
A	ASP72

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 203

Chain	Residue
A	HIS21
A	ASP31
A	HIS92
A	HIS96

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 204

Chain	Residue
A	GLU65
A	HIS103
A	HIS105
A	HIS107

---

site_id	AC5
Number of Residues	10
Details	binding site for residue SO4 A 205

Chain	Residue
A	LYS35
A	LYS35
A	ARG39
A	ARG39
A	ASN61
A	ASN61
A	HIS105
A	HIS105
A	HOH340
A	HOH340

---

Functional Information from PROSITE/UniProt

site_id	PS00303
Number of Residues	22
Details	S100_CABP S-100/ICaBP type calcium binding protein signature. IMedLDtnqDnqlSFeECmmLM

Chain	Residue	Details
A	ILE63-MET84

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	35
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	35
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	13
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P06702","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Pros-methylhistidine","evidences":[{"source":"PubMed","id":"33563959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34562450","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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