Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004303 | molecular_function | estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006706 | biological_process | steroid catabolic process |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0047045 | molecular_function | testosterone 17-beta-dehydrogenase (NADP+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue QFZ A 301 |
| Chain | Residue |
| A | HIS93 |
| A | NAD302 |
| A | HOH462 |
| A | SER141 |
| A | VAL143 |
| A | GLN148 |
| A | TYR154 |
| A | ASN186 |
| A | LEU191 |
| A | TRP192 |
| A | TYR253 |
| site_id | AC2 |
| Number of Residues | 30 |
| Details | binding site for residue NAD A 302 |
| Chain | Residue |
| A | GLY16 |
| A | ARG19 |
| A | GLY20 |
| A | ILE21 |
| A | ASP40 |
| A | LYS41 |
| A | CYS61 |
| A | ASP62 |
| A | VAL63 |
| A | ASN89 |
| A | LEU113 |
| A | ILE139 |
| A | SER140 |
| A | SER141 |
| A | TYR154 |
| A | LYS158 |
| A | PRO184 |
| A | GLY185 |
| A | ASN186 |
| A | ILE187 |
| A | THR189 |
| A | PRO190 |
| A | LEU191 |
| A | TRP192 |
| A | QFZ301 |
| A | HOH404 |
| A | HOH433 |
| A | HOH443 |
| A | HOH458 |
| A | HOH496 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 303 |
| Chain | Residue |
| A | GLU50 |
| A | LEU53 |
| A | PRO54 |
| A | ALA56 |
| A | HOH503 |
| A | HOH513 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SlvgaigqaqAvpYVATKGAVtAMTkALA |
| Chain | Residue | Details |
| A | SER141-ALA169 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | TYR154 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | VAL13 | |
| A | SER141 | |
| A | LYS158 | |
