6ZCM

Crystal structure of YTHDC1 with compound DHU_DC1_180

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
B	0003723	molecular_function	RNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue QF2 A 601

Chain	Residue
A	LYS361
A	PRO431
A	MET434
A	ASP476
A	HOH701
A	ASN363
A	ASN367
A	TRP377
A	SER378
A	THR379
A	LEU380
A	ARG404
A	TRP428

---

site_id	AC2
Number of Residues	9
Details	binding site for residue SO4 A 602

Chain	Residue
A	GLY344
A	THR345
A	SER346
A	LYS347
A	HOH702
A	HOH717
A	HOH771
B	LYS386
B	GLU479

---

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 603

Chain	Residue
A	HIS420
A	HIS421
A	HOH705

---

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 604

Chain	Residue
A	ARG451
A	PRO494
A	HOH715

---

site_id	AC5
Number of Residues	14
Details	binding site for residue QF2 B 601

Chain	Residue
B	LYS361
B	ASN363
B	TRP377
B	SER378
B	THR379
B	LEU380
B	ARG404
B	TRP428
B	LEU430
B	PRO431
B	MET434
B	ASP476
B	HOH775
B	HOH783

---

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 B 602

Chain	Residue
B	ARG451
B	GLU452
B	HOH737
B	HOH766
B	HOH767
B	HOH802
B	HOH835

---

site_id	AC7
Number of Residues	6
Details	binding site for residue SO4 B 603

Chain	Residue
B	LYS347
B	HOH749
B	HOH764
B	HOH793
B	HOH818
B	HOH838

---

site_id	AC8
Number of Residues	7
Details	binding site for residue SO4 B 604

Chain	Residue
B	LYS361
B	ARG404
B	ARG475
B	ASP476
B	HOH719
B	HOH746
B	HOH775

---

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 B 605

Chain	Residue
B	SER419
B	HIS420
B	HIS421
B	ARG451

---

site_id	AD1
Number of Residues	7
Details	binding site for residue SO4 B 606

Chain	Residue
B	LYS385
B	ASN388
B	ARG392
B	LYS457
B	HOH709
B	HOH717
B	HOH863

---

site_id	AD2
Number of Residues	3
Details	binding site for residue SO4 B 607

Chain	Residue
B	ASN364
B	HIS365
B	HOH704

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	274
Details	Domain: {"description":"YTH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00225","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31670957","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25242552","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31670957","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25242552","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---