6Z81
TsaBD bound to the inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0000408 | cellular_component | EKC/KEOPS complex |
| A | 0002949 | biological_process | tRNA threonylcarbamoyladenosine modification |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006400 | biological_process | tRNA modification |
| A | 0008033 | biological_process | tRNA processing |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0061711 | molecular_function | N(6)-L-threonylcarbamoyladenine synthase activity |
| A | 0070525 | biological_process | tRNA threonylcarbamoyladenosine metabolic process |
| A | 0140032 | molecular_function | glycosylation-dependent protein binding |
| A | 1990145 | biological_process | maintenance of translational fidelity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0000408 | cellular_component | EKC/KEOPS complex |
| B | 0002949 | biological_process | tRNA threonylcarbamoyladenosine modification |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006400 | biological_process | tRNA modification |
| B | 0008033 | biological_process | tRNA processing |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0061711 | molecular_function | N(6)-L-threonylcarbamoyladenine synthase activity |
| B | 0070525 | biological_process | tRNA threonylcarbamoyladenosine metabolic process |
| B | 0140032 | molecular_function | glycosylation-dependent protein binding |
| B | 1990145 | biological_process | maintenance of translational fidelity |
| C | 0000408 | cellular_component | EKC/KEOPS complex |
| C | 0002949 | biological_process | tRNA threonylcarbamoyladenosine modification |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0008033 | biological_process | tRNA processing |
| C | 0008237 | molecular_function | metallopeptidase activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 1990145 | biological_process | maintenance of translational fidelity |
| D | 0000408 | cellular_component | EKC/KEOPS complex |
| D | 0002949 | biological_process | tRNA threonylcarbamoyladenosine modification |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0008033 | biological_process | tRNA processing |
| D | 0008237 | molecular_function | metallopeptidase activity |
| D | 0042802 | molecular_function | identical protein binding |
| D | 1990145 | biological_process | maintenance of translational fidelity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue NI A 402 |
| Chain | Residue |
| A | LEU321 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 403 |
| Chain | Residue |
| A | HIS111 |
| A | HIS115 |
| A | ASP300 |
| A | QCB404 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | binding site for residue QCB A 404 |
| Chain | Residue |
| A | MET112 |
| A | HIS115 |
| A | SER136 |
| A | GLY137 |
| A | GLY138 |
| A | HIS139 |
| A | GLY163 |
| A | ASP167 |
| A | GLY180 |
| A | PRO181 |
| A | GLY268 |
| A | VAL269 |
| A | ASN272 |
| A | THR299 |
| A | ASP300 |
| A | ZN403 |
| A | HOH505 |
| A | SER9 |
| A | CYS10 |
| A | PRO82 |
| A | HIS111 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 A 405 |
| Chain | Residue |
| A | ARG237 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 406 |
| Chain | Residue |
| A | LYS168 |
| A | LYS171 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 408 |
| Chain | Residue |
| A | ASP20 |
| A | TYR307 |
| A | MET310 |
| A | VAL311 |
| A | LYS314 |
| A | HIS340 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue ACT A 409 |
| Chain | Residue |
| A | LYS252 |
| A | ARG253 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue PEG A 410 |
| Chain | Residue |
| A | PHE100 |
| A | ASP103 |
| A | HOH511 |
| B | HIS338 |
| B | HIS339 |
| B | HIS340 |
| B | NI402 |
| C | GLN43 |
| C | NA301 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 411 |
| Chain | Residue |
| A | GLN150 |
| A | ALA337 |
| A | HIS338 |
| B | LEU321 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 412 |
| Chain | Residue |
| A | THR146 |
| A | GLN150 |
| D | GLN43 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue NI B 401 |
| Chain | Residue |
| B | NI402 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue NI B 402 |
| Chain | Residue |
| A | PEG410 |
| B | HIS338 |
| B | NI401 |
| C | GLN43 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 403 |
| Chain | Residue |
| B | HIS111 |
| B | HIS115 |
| B | ASP300 |
| B | QCB404 |
| site_id | AD5 |
| Number of Residues | 22 |
| Details | binding site for residue QCB B 404 |
| Chain | Residue |
| B | SER9 |
| B | CYS10 |
| B | GLU12 |
| B | PRO82 |
| B | HIS111 |
| B | MET112 |
| B | HIS115 |
| B | SER136 |
| B | GLY137 |
| B | GLY138 |
| B | HIS139 |
| B | GLY163 |
| B | ASP167 |
| B | GLY180 |
| B | PRO181 |
| B | GLY268 |
| B | VAL269 |
| B | ASN272 |
| B | THR299 |
| B | ASP300 |
| B | ZN403 |
| B | HOH503 |
| site_id | AD6 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 B 405 |
| Chain | Residue |
| B | ARG237 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 406 |
| Chain | Residue |
| B | LYS168 |
| B | LYS171 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue ACT B 407 |
| Chain | Residue |
| B | THR202 |
| B | LYS252 |
| B | ARG253 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue PEG B 408 |
| Chain | Residue |
| B | GLY259 |
| B | LYS261 |
| B | ARG262 |
| B | HOH511 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue NA C 301 |
| Chain | Residue |
| A | PEG410 |
| C | LEU53 |
| site_id | AE2 |
| Number of Residues | 9 |
| Details | binding site for residue AMP C 302 |
| Chain | Residue |
| C | HIS34 |
| C | THR35 |
| C | SER67 |
| C | THR69 |
| C | HOH410 |
| C | HOH412 |
| A | VAL85 |
| C | ARG32 |
| C | GLU33 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue ACT C 303 |
| Chain | Residue |
| C | PRO215 |
| C | TYR217 |
| C | LEU218 |
| C | ASN220 |
| site_id | AE4 |
| Number of Residues | 8 |
| Details | binding site for residue ACT C 304 |
| Chain | Residue |
| C | SER14 |
| C | VAL15 |
| C | ALA25 |
| C | HIS26 |
| C | PHE27 |
| C | ALA190 |
| C | ALA191 |
| C | GLU192 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue ACT C 305 |
| Chain | Residue |
| C | VAL143 |
| C | LEU218 |
| C | ASN220 |
| C | ASN221 |
| site_id | AE6 |
| Number of Residues | 1 |
| Details | binding site for residue NA D 301 |
| Chain | Residue |
| D | ASN220 |
| site_id | AE7 |
| Number of Residues | 7 |
| Details | binding site for residue AMP D 302 |
| Chain | Residue |
| B | VAL85 |
| D | HIS34 |
| D | THR35 |
| D | SER67 |
| D | THR69 |
| D | HOH404 |
| D | HOH408 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue ACT D 303 |
| Chain | Residue |
| D | TYR217 |
| D | LEU218 |
| D | ASN220 |
| site_id | AE9 |
| Number of Residues | 2 |
| Details | binding site for residue ACT D 304 |
| Chain | Residue |
| D | LEU187 |
| D | LEU188 |
Functional Information from PROSITE/UniProt
| site_id | PS01016 |
| Number of Residues | 21 |
| Details | GLYCOPROTEASE Glycoprotease family signature. RSlafaWDvPaIpvhHmeGHL |
| Chain | Residue | Details |
| A | ARG96-LEU116 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01445 |
| Chain | Residue | Details |
| A | HIS111 | |
| B | LEU134 | |
| B | ASP167 | |
| B | GLY180 | |
| B | ASN272 | |
| B | ASP300 | |
| A | HIS115 | |
| A | LEU134 | |
| A | ASP167 | |
| A | GLY180 | |
| A | ASN272 | |
| A | ASP300 | |
| B | HIS111 | |
| B | HIS115 |
