Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6Z6P

HDAC-PC-Nuc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0030527	molecular_function	structural constituent of chromatin
A	0046982	molecular_function	protein heterodimerization activity
B	0003677	molecular_function	DNA binding
B	0030527	molecular_function	structural constituent of chromatin
B	0046982	molecular_function	protein heterodimerization activity
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0030527	molecular_function	structural constituent of chromatin
C	0046982	molecular_function	protein heterodimerization activity
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0030527	molecular_function	structural constituent of chromatin
D	0046982	molecular_function	protein heterodimerization activity
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0030527	molecular_function	structural constituent of chromatin
E	0046982	molecular_function	protein heterodimerization activity
F	0003677	molecular_function	DNA binding
F	0030527	molecular_function	structural constituent of chromatin
F	0046982	molecular_function	protein heterodimerization activity
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0030527	molecular_function	structural constituent of chromatin
G	0046982	molecular_function	protein heterodimerization activity
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0030527	molecular_function	structural constituent of chromatin
H	0046982	molecular_function	protein heterodimerization activity
K	0000118	cellular_component	histone deacetylase complex
K	0000122	biological_process	negative regulation of transcription by RNA polymerase II
K	0003682	molecular_function	chromatin binding
K	0004407	molecular_function	histone deacetylase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0006325	biological_process	chromatin organization
K	0006355	biological_process	regulation of DNA-templated transcription
K	0008270	molecular_function	zinc ion binding
K	0010621	biological_process	negative regulation of transcription by transcription factor localization
K	0016787	molecular_function	hydrolase activity
K	0040029	biological_process	epigenetic regulation of gene expression
K	0042802	molecular_function	identical protein binding
K	0045944	biological_process	positive regulation of transcription by RNA polymerase II
K	0070823	cellular_component	HDA1 complex
L	0000118	cellular_component	histone deacetylase complex
L	0000122	biological_process	negative regulation of transcription by RNA polymerase II
L	0003682	molecular_function	chromatin binding
L	0004407	molecular_function	histone deacetylase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0006325	biological_process	chromatin organization
L	0006355	biological_process	regulation of DNA-templated transcription
L	0008270	molecular_function	zinc ion binding
L	0010621	biological_process	negative regulation of transcription by transcription factor localization
L	0016787	molecular_function	hydrolase activity
L	0040029	biological_process	epigenetic regulation of gene expression
L	0042802	molecular_function	identical protein binding
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0070823	cellular_component	HDA1 complex
M	0005634	cellular_component	nucleus
M	0070823	cellular_component	HDA1 complex
N	0000122	biological_process	negative regulation of transcription by RNA polymerase II
N	0003677	molecular_function	DNA binding
N	0003682	molecular_function	chromatin binding
N	0004407	molecular_function	histone deacetylase activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006325	biological_process	chromatin organization
N	0006338	biological_process	chromatin remodeling
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0031047	biological_process	regulatory ncRNA-mediated gene silencing
N	0070823	cellular_component	HDA1 complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN K 801

Chain	Residue
K	PRO203
K	HIS205
K	ASP245
K	GLU375
K	GLY376

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN L 801

Chain	Residue
L	ASP245
L	HIS247
L	ASP338
L	TYR378

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. KYQIESSKAAESAQTL

Chain	Residue	Details
N	LYS570-LEU585

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
G	ALA21-VAL27
C	ALA21-VAL27

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG89-GLY111
H	ARG89-GLY111

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
E	PRO66-ILE74
A	PRO66-ILE74

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
A	TYR41
F	LYS91

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P84228

Chain	Residue	Details
A	LYS56
A	LYS79

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
A	SER57
B	LYS79

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
A	LYS64
F	TYR88

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
A	THR80
A	THR107

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P84243

Chain	Residue	Details
A	SER86

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
A	LYS115

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
A	LYS122
F	LYS91

site_id	SWS_FT_FI9
Number of Residues	1
Details	LIPID: S-palmitoyl cysteine => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
A	CYS110
B	LYS91

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)