Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6Z6O

HDAC-TC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000118	cellular_component	histone deacetylase complex
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0003682	molecular_function	chromatin binding
A	0004407	molecular_function	histone deacetylase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006325	biological_process	chromatin organization
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
A	0010557	biological_process	positive regulation of macromolecule biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0040029	biological_process	epigenetic regulation of gene expression
A	0042802	molecular_function	identical protein binding
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0070823	cellular_component	HDA1 complex
A	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
B	0000118	cellular_component	histone deacetylase complex
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0003682	molecular_function	chromatin binding
B	0004407	molecular_function	histone deacetylase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006325	biological_process	chromatin organization
B	0006351	biological_process	DNA-templated transcription
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008270	molecular_function	zinc ion binding
B	0010557	biological_process	positive regulation of macromolecule biosynthetic process
B	0016787	molecular_function	hydrolase activity
B	0040029	biological_process	epigenetic regulation of gene expression
B	0042802	molecular_function	identical protein binding
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0070823	cellular_component	HDA1 complex
B	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0003677	molecular_function	DNA binding
C	0003682	molecular_function	chromatin binding
C	0004407	molecular_function	histone deacetylase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006325	biological_process	chromatin organization
C	0006338	biological_process	chromatin remodeling
C	0006351	biological_process	DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0031047	biological_process	regulatory ncRNA-mediated gene silencing
C	0070823	cellular_component	HDA1 complex
D	0005634	cellular_component	nucleus
D	0070823	cellular_component	HDA1 complex
E	0000118	cellular_component	histone deacetylase complex
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0003682	molecular_function	chromatin binding
E	0004407	molecular_function	histone deacetylase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0006325	biological_process	chromatin organization
E	0006351	biological_process	DNA-templated transcription
E	0006355	biological_process	regulation of DNA-templated transcription
E	0008270	molecular_function	zinc ion binding
E	0010557	biological_process	positive regulation of macromolecule biosynthetic process
E	0016787	molecular_function	hydrolase activity
E	0040029	biological_process	epigenetic regulation of gene expression
E	0042802	molecular_function	identical protein binding
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0070823	cellular_component	HDA1 complex
E	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
F	0000118	cellular_component	histone deacetylase complex
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0003682	molecular_function	chromatin binding
F	0004407	molecular_function	histone deacetylase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0006325	biological_process	chromatin organization
F	0006351	biological_process	DNA-templated transcription
F	0006355	biological_process	regulation of DNA-templated transcription
F	0008270	molecular_function	zinc ion binding
F	0010557	biological_process	positive regulation of macromolecule biosynthetic process
F	0016787	molecular_function	hydrolase activity
F	0040029	biological_process	epigenetic regulation of gene expression
F	0042802	molecular_function	identical protein binding
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0070823	cellular_component	HDA1 complex
F	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0003677	molecular_function	DNA binding
G	0003682	molecular_function	chromatin binding
G	0004407	molecular_function	histone deacetylase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006325	biological_process	chromatin organization
G	0006338	biological_process	chromatin remodeling
G	0006351	biological_process	DNA-templated transcription
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0031047	biological_process	regulatory ncRNA-mediated gene silencing
G	0070823	cellular_component	HDA1 complex
H	0005634	cellular_component	nucleus
H	0070823	cellular_component	HDA1 complex
I	0000118	cellular_component	histone deacetylase complex
I	0000122	biological_process	negative regulation of transcription by RNA polymerase II
I	0003682	molecular_function	chromatin binding
I	0004407	molecular_function	histone deacetylase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0006325	biological_process	chromatin organization
I	0006351	biological_process	DNA-templated transcription
I	0006355	biological_process	regulation of DNA-templated transcription
I	0008270	molecular_function	zinc ion binding
I	0010557	biological_process	positive regulation of macromolecule biosynthetic process
I	0016787	molecular_function	hydrolase activity
I	0040029	biological_process	epigenetic regulation of gene expression
I	0042802	molecular_function	identical protein binding
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0070823	cellular_component	HDA1 complex
I	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
J	0000118	cellular_component	histone deacetylase complex
J	0000122	biological_process	negative regulation of transcription by RNA polymerase II
J	0003682	molecular_function	chromatin binding
J	0004407	molecular_function	histone deacetylase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0006325	biological_process	chromatin organization
J	0006351	biological_process	DNA-templated transcription
J	0006355	biological_process	regulation of DNA-templated transcription
J	0008270	molecular_function	zinc ion binding
J	0010557	biological_process	positive regulation of macromolecule biosynthetic process
J	0016787	molecular_function	hydrolase activity
J	0040029	biological_process	epigenetic regulation of gene expression
J	0042802	molecular_function	identical protein binding
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0070823	cellular_component	HDA1 complex
J	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
K	0000122	biological_process	negative regulation of transcription by RNA polymerase II
K	0003677	molecular_function	DNA binding
K	0003682	molecular_function	chromatin binding
K	0004407	molecular_function	histone deacetylase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006325	biological_process	chromatin organization
K	0006338	biological_process	chromatin remodeling
K	0006351	biological_process	DNA-templated transcription
K	0006357	biological_process	regulation of transcription by RNA polymerase II
K	0031047	biological_process	regulatory ncRNA-mediated gene silencing
K	0070823	cellular_component	HDA1 complex
L	0005634	cellular_component	nucleus
L	0070823	cellular_component	HDA1 complex
M	0000118	cellular_component	histone deacetylase complex
M	0000122	biological_process	negative regulation of transcription by RNA polymerase II
M	0003682	molecular_function	chromatin binding
M	0004407	molecular_function	histone deacetylase activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0006325	biological_process	chromatin organization
M	0006351	biological_process	DNA-templated transcription
M	0006355	biological_process	regulation of DNA-templated transcription
M	0008270	molecular_function	zinc ion binding
M	0010557	biological_process	positive regulation of macromolecule biosynthetic process
M	0016787	molecular_function	hydrolase activity
M	0040029	biological_process	epigenetic regulation of gene expression
M	0042802	molecular_function	identical protein binding
M	0045944	biological_process	positive regulation of transcription by RNA polymerase II
M	0070823	cellular_component	HDA1 complex
M	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
N	0000118	cellular_component	histone deacetylase complex
N	0000122	biological_process	negative regulation of transcription by RNA polymerase II
N	0003682	molecular_function	chromatin binding
N	0004407	molecular_function	histone deacetylase activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0006325	biological_process	chromatin organization
N	0006351	biological_process	DNA-templated transcription
N	0006355	biological_process	regulation of DNA-templated transcription
N	0008270	molecular_function	zinc ion binding
N	0010557	biological_process	positive regulation of macromolecule biosynthetic process
N	0016787	molecular_function	hydrolase activity
N	0040029	biological_process	epigenetic regulation of gene expression
N	0042802	molecular_function	identical protein binding
N	0045944	biological_process	positive regulation of transcription by RNA polymerase II
N	0070823	cellular_component	HDA1 complex
N	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
O	0000122	biological_process	negative regulation of transcription by RNA polymerase II
O	0003677	molecular_function	DNA binding
O	0003682	molecular_function	chromatin binding
O	0004407	molecular_function	histone deacetylase activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006325	biological_process	chromatin organization
O	0006338	biological_process	chromatin remodeling
O	0006351	biological_process	DNA-templated transcription
O	0006357	biological_process	regulation of transcription by RNA polymerase II
O	0031047	biological_process	regulatory ncRNA-mediated gene silencing
O	0070823	cellular_component	HDA1 complex
P	0005634	cellular_component	nucleus
P	0070823	cellular_component	HDA1 complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue ZN A 801

Chain	Residue
A	ASP245
A	HIS247
A	ASP338

site_id	AC2
Number of Residues	3
Details	binding site for residue ZN B 801

Chain	Residue
B	ASP245
B	HIS247
B	ASP338

site_id	AC3
Number of Residues	3
Details	binding site for residue ZN E 801

Chain	Residue
E	ASP245
E	HIS247
E	ASP338

site_id	AC4
Number of Residues	3
Details	binding site for residue ZN F 801

Chain	Residue
F	ASP245
F	HIS247
F	ASP338

site_id	AC5
Number of Residues	3
Details	binding site for residue ZN I 801

Chain	Residue
I	ASP245
I	HIS247
I	ASP338

site_id	AC6
Number of Residues	3
Details	binding site for residue ZN J 801

Chain	Residue
J	ASP245
J	HIS247
J	ASP338

site_id	AC7
Number of Residues	3
Details	binding site for residue ZN M 801

Chain	Residue
M	ASP245
M	HIS247
M	ASP338

site_id	AC8
Number of Residues	3
Details	binding site for residue ZN N 801

Chain	Residue
N	ASP245
N	HIS247
N	ASP338

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. KYQIESSKAAESAQTL

Chain	Residue	Details
C	LYS570-LEU585

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2632
Details	Region: {"description":"Histone deacetylase"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	600
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)