6Z6H

HDAC-DC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000118	cellular_component	histone deacetylase complex
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0003682	molecular_function	chromatin binding
A	0004407	molecular_function	histone deacetylase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006325	biological_process	chromatin organization
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
A	0010557	biological_process	positive regulation of macromolecule biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0040029	biological_process	epigenetic regulation of gene expression
A	0042802	molecular_function	identical protein binding
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0070823	cellular_component	HDA1 complex
A	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
B	0000118	cellular_component	histone deacetylase complex
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0003682	molecular_function	chromatin binding
B	0004407	molecular_function	histone deacetylase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006325	biological_process	chromatin organization
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008270	molecular_function	zinc ion binding
B	0010557	biological_process	positive regulation of macromolecule biosynthetic process
B	0016787	molecular_function	hydrolase activity
B	0040029	biological_process	epigenetic regulation of gene expression
B	0042802	molecular_function	identical protein binding
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0070823	cellular_component	HDA1 complex
B	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0003677	molecular_function	DNA binding
C	0003682	molecular_function	chromatin binding
C	0004407	molecular_function	histone deacetylase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006325	biological_process	chromatin organization
C	0006338	biological_process	chromatin remodeling
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0031047	biological_process	regulatory ncRNA-mediated gene silencing
C	0070823	cellular_component	HDA1 complex
D	0005634	cellular_component	nucleus
D	0070823	cellular_component	HDA1 complex
F	0000118	cellular_component	histone deacetylase complex
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0003682	molecular_function	chromatin binding
F	0004407	molecular_function	histone deacetylase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0006325	biological_process	chromatin organization
F	0006355	biological_process	regulation of DNA-templated transcription
F	0008270	molecular_function	zinc ion binding
F	0010557	biological_process	positive regulation of macromolecule biosynthetic process
F	0016787	molecular_function	hydrolase activity
F	0040029	biological_process	epigenetic regulation of gene expression
F	0042802	molecular_function	identical protein binding
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0070823	cellular_component	HDA1 complex
F	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
G	0000118	cellular_component	histone deacetylase complex
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0003682	molecular_function	chromatin binding
G	0004407	molecular_function	histone deacetylase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0006325	biological_process	chromatin organization
G	0006355	biological_process	regulation of DNA-templated transcription
G	0008270	molecular_function	zinc ion binding
G	0010557	biological_process	positive regulation of macromolecule biosynthetic process
G	0016787	molecular_function	hydrolase activity
G	0040029	biological_process	epigenetic regulation of gene expression
G	0042802	molecular_function	identical protein binding
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0070823	cellular_component	HDA1 complex
G	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
I	0000122	biological_process	negative regulation of transcription by RNA polymerase II
I	0003677	molecular_function	DNA binding
I	0003682	molecular_function	chromatin binding
I	0004407	molecular_function	histone deacetylase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006325	biological_process	chromatin organization
I	0006338	biological_process	chromatin remodeling
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0031047	biological_process	regulatory ncRNA-mediated gene silencing
I	0070823	cellular_component	HDA1 complex
J	0005634	cellular_component	nucleus
J	0070823	cellular_component	HDA1 complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 801

Chain	Residue
A	HIS205
A	ASP245
A	GLU375
A	GLY376

---

site_id	AC2
Number of Residues	5
Details	binding site for residue ZN B 801

Chain	Residue
B	HIS205
B	HIS206
B	ASP245
B	HIS247
B	ASP338

---

site_id	AC3
Number of Residues	3
Details	binding site for residue ZN F 801

Chain	Residue
F	HIS205
F	HIS206
F	HIS247

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN G 801

Chain	Residue
G	HIS205
G	ASP245
G	HIS247
G	ASP338

---

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. KYQIESSKAAESAQTL

Chain	Residue	Details
C	LYS570-LEU585

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1316
Details	Region: {"description":"Histone deacetylase"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	300
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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