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6Z6F

HDAC-PC

Functional Information from GO Data
ChainGOidnamespacecontents
A0000118cellular_componenthistone deacetylase complex
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0003682molecular_functionchromatin binding
A0004407molecular_functionhistone deacetylase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0006325biological_processchromatin organization
A0006355biological_processregulation of DNA-templated transcription
A0008270molecular_functionzinc ion binding
A0010557biological_processpositive regulation of macromolecule biosynthetic process
A0010621biological_processnegative regulation of transcription by transcription factor localization
A0016787molecular_functionhydrolase activity
A0040029biological_processepigenetic regulation of gene expression
A0042802molecular_functionidentical protein binding
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0070823cellular_componentHDA1 complex
A0141221molecular_functionhistone deacetylase activity, hydrolytic mechanism
B0000118cellular_componenthistone deacetylase complex
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0003682molecular_functionchromatin binding
B0004407molecular_functionhistone deacetylase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0006325biological_processchromatin organization
B0006355biological_processregulation of DNA-templated transcription
B0008270molecular_functionzinc ion binding
B0010557biological_processpositive regulation of macromolecule biosynthetic process
B0010621biological_processnegative regulation of transcription by transcription factor localization
B0016787molecular_functionhydrolase activity
B0040029biological_processepigenetic regulation of gene expression
B0042802molecular_functionidentical protein binding
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0070823cellular_componentHDA1 complex
B0141221molecular_functionhistone deacetylase activity, hydrolytic mechanism
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0003677molecular_functionDNA binding
C0003682molecular_functionchromatin binding
C0004407molecular_functionhistone deacetylase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006325biological_processchromatin organization
C0006357biological_processregulation of transcription by RNA polymerase II
C0031047biological_processregulatory ncRNA-mediated gene silencing
C0070823cellular_componentHDA1 complex
D0005634cellular_componentnucleus
D0070823cellular_componentHDA1 complex
Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue ZN A 801
ChainResidue
AASP245
AHIS247
AASP338

site_idAC2
Number of Residues3
Detailsbinding site for residue ZN B 801
ChainResidue
BASP245
BHIS247
BASP338

Functional Information from PROSITE/UniProt
site_idPS00012
Number of Residues16
DetailsPHOSPHOPANTETHEINE Phosphopantetheine attachment site. KYQIESSKAAESAQTL
ChainResidueDetails
CLYS570-LEU585

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues658
DetailsRegion: {"description":"Histone deacetylase"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsActive site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues150
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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