6Z5T
SARS-CoV-2 Macrodomain in complex with ADP-ribose
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | binding site for residue APR A 401 |
| Chain | Residue |
| A | ASP226 |
| A | VAL253 |
| A | ALA254 |
| A | LEU330 |
| A | SER332 |
| A | ALA333 |
| A | GLY334 |
| A | ILE335 |
| A | PHE336 |
| A | ALA358 |
| A | PHE360 |
| A | ILE227 |
| A | HOH505 |
| A | HOH530 |
| A | HOH537 |
| A | HOH539 |
| A | HOH541 |
| A | HOH547 |
| A | HOH548 |
| A | HOH561 |
| A | HOH562 |
| A | HOH581 |
| A | ALA242 |
| A | HOH610 |
| A | ASN244 |
| A | LYS248 |
| A | HIS249 |
| A | GLY250 |
| A | GLY251 |
| A | GLY252 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 402 |
| Chain | Residue |
| A | ASN224 |
| A | HOH525 |
| A | HOH526 |
| A | HOH559 |
| A | HOH580 |
| site_id | AC3 |
| Number of Residues | 29 |
| Details | binding site for residue APR B 401 |
| Chain | Residue |
| A | GLU324 |
| B | ASP226 |
| B | ILE227 |
| B | ALA242 |
| B | ASN244 |
| B | LYS248 |
| B | HIS249 |
| B | GLY250 |
| B | GLY251 |
| B | GLY252 |
| B | VAL253 |
| B | ALA254 |
| B | LEU330 |
| B | SER332 |
| B | ALA333 |
| B | GLY334 |
| B | ILE335 |
| B | PHE336 |
| B | ALA358 |
| B | PHE360 |
| B | HOH508 |
| B | HOH515 |
| B | HOH520 |
| B | HOH529 |
| B | HOH541 |
| B | HOH567 |
| B | HOH569 |
| B | HOH576 |
| B | HOH590 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 402 |
| Chain | Residue |
| B | ASN224 |
| B | TYR365 |
| B | HOH572 |
| B | HOH592 |
| B | HOH639 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 338 |
| Details | Domain: {"description":"Macro 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00490","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For ADP-ribosylhydrolase activity","evidences":[{"source":"PubMed","id":"37242344","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"K9N638","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
