6Z5F
CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE-1 (RPMFE1) COMPLEXED WITH 3-KETODECANOYL-COA AND OXIDISED NICOTINAMIDE ADENINE DINUCLEOTIDE
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| AAA | 0003824 | molecular_function | catalytic activity |
| AAA | 0003857 | molecular_function | 3-hydroxyacyl-CoA dehydrogenase activity |
| AAA | 0004165 | molecular_function | delta(3)-delta(2)-enoyl-CoA isomerase activity |
| AAA | 0004300 | molecular_function | enoyl-CoA hydratase activity |
| AAA | 0005777 | cellular_component | peroxisome |
| AAA | 0005829 | cellular_component | cytosol |
| AAA | 0006631 | biological_process | fatty acid metabolic process |
| AAA | 0006635 | biological_process | fatty acid beta-oxidation |
| AAA | 0016491 | molecular_function | oxidoreductase activity |
| AAA | 0016509 | molecular_function | long-chain-3-hydroxyacyl-CoA dehydrogenase activity |
| AAA | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| AAA | 0016829 | molecular_function | lyase activity |
| AAA | 0016853 | molecular_function | isomerase activity |
| AAA | 0016863 | molecular_function | intramolecular oxidoreductase activity, transposing C=C bonds |
| AAA | 0019899 | molecular_function | enzyme binding |
| AAA | 0070403 | molecular_function | NAD+ binding |
| BBB | 0003824 | molecular_function | catalytic activity |
| BBB | 0003857 | molecular_function | 3-hydroxyacyl-CoA dehydrogenase activity |
| BBB | 0004165 | molecular_function | delta(3)-delta(2)-enoyl-CoA isomerase activity |
| BBB | 0004300 | molecular_function | enoyl-CoA hydratase activity |
| BBB | 0005777 | cellular_component | peroxisome |
| BBB | 0005829 | cellular_component | cytosol |
| BBB | 0006631 | biological_process | fatty acid metabolic process |
| BBB | 0006635 | biological_process | fatty acid beta-oxidation |
| BBB | 0016491 | molecular_function | oxidoreductase activity |
| BBB | 0016509 | molecular_function | long-chain-3-hydroxyacyl-CoA dehydrogenase activity |
| BBB | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| BBB | 0016829 | molecular_function | lyase activity |
| BBB | 0016853 | molecular_function | isomerase activity |
| BBB | 0016863 | molecular_function | intramolecular oxidoreductase activity, transposing C=C bonds |
| BBB | 0019899 | molecular_function | enzyme binding |
| BBB | 0070403 | molecular_function | NAD+ binding |
Functional Information from PROSITE/UniProt
| site_id | PS00067 |
| Number of Residues | 25 |
| Details | 3HCDH 3-hydroxyacyl-CoA dehydrogenase signature. NcyGFVgNRmlaPYYnqgff.LLeeG |
| Chain | Residue | Details |
| AAA | ASN474-GLY498 |
| site_id | PS00166 |
| Number of Residues | 21 |
| Details | ENOYL_COA_HYDRATASE Enoyl-CoA hydratase/isomerase signature. LAaIQGvalGGGlelaLgCHY |
| Chain | Residue | Details |
| AAA | LEU90-TYR110 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| BBB | GLY100 | |
| AAA | GLY100 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Important for catalytic activity => ECO:0000250 |
| Chain | Residue | Details |
| BBB | GLU103 | |
| BBB | GLU123 | |
| AAA | GLU103 | |
| AAA | GLU123 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Blocked amino end (Ala) |
| Chain | Residue | Details |
| BBB | ALA2 | |
| AAA | ALA2 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9DBM2 |
| Chain | Residue | Details |
| BBB | LYS38 | |
| BBB | LYS182 | |
| BBB | LYS241 | |
| BBB | LYS253 | |
| BBB | LYS279 | |
| BBB | LYS289 | |
| BBB | LYS330 | |
| BBB | LYS531 | |
| BBB | LYS576 | |
| BBB | LYS721 | |
| AAA | LYS38 | |
| AAA | LYS182 | |
| AAA | LYS241 | |
| AAA | LYS253 | |
| AAA | LYS279 | |
| AAA | LYS289 | |
| AAA | LYS330 | |
| AAA | LYS531 | |
| AAA | LYS576 | |
| AAA | LYS721 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 14 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9DBM2 |
| Chain | Residue | Details |
| BBB | LYS173 | |
| BBB | LYS190 | |
| BBB | LYS218 | |
| BBB | LYS275 | |
| BBB | LYS583 | |
| BBB | LYS590 | |
| BBB | LYS709 | |
| AAA | LYS173 | |
| AAA | LYS190 | |
| AAA | LYS218 | |
| AAA | LYS275 | |
| AAA | LYS583 | |
| AAA | LYS590 | |
| AAA | LYS709 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9DBM2 |
| Chain | Residue | Details |
| BBB | LYS359 | |
| BBB | LYS463 | |
| AAA | LYS359 | |
| AAA | LYS463 | |
| BBB | LYS249 | |
| AAA | LYS249 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q08426 |
| Chain | Residue | Details |
| BBB | LYS345 | |
| AAA | LYS345 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q08426 |
| Chain | Residue | Details |
| AAA | THR547 | |
| BBB | THR547 |
