6Z56

Crystal structure of haspin (GSG2) in complex with macrocycle ODS2003208

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue Q7Q A 801

Chain	Residue
A	ILE490
A	GLU606
A	GLY608
A	GLY609
A	LEU656
A	ILE686
A	ASP687
A	GLU492
A	GLY493
A	GLY496
A	ALA509
A	LYS511
A	GLU535
A	SER539
A	PHE605

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site_id	AC2
Number of Residues	5
Details	binding site for residue DMS A 802

Chain	Residue
A	TYR667
A	LYS672
A	HOH926
A	HOH1034
A	HOH1148

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	22
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGVFGEVFqTiadhtp............VAIK

Chain	Residue	Details
A	ILE490-LYS511

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ASP649

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE490
A	LYS511

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:19918057, ECO:0007744|PDB:3DLZ

Chain	Residue	Details
A	GLU606
A	ASP649

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:19918057

Chain	Residue	Details
A	ASP687

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