6Z4Y

Crystal structure of Aurora A (STK6) in complex with macrocycle ODS2003208

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000212	biological_process	meiotic spindle organization
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007052	biological_process	mitotic spindle organization
A	0007098	biological_process	centrosome cycle
A	0007100	biological_process	mitotic centrosome separation
A	0051321	biological_process	meiotic cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue CIT A 501

Chain	Residue
A	SER266
A	THR333
A	GLU336
A	GLU336
A	LYS339
A	ARG340
A	ARG343
A	HOH639

---

site_id	AC2
Number of Residues	8
Details	binding site for residue CIT A 502

Chain	Residue
A	GLU175
A	HIS176
A	ARG180
A	ARG180
A	HIS280
A	ALA281
A	HOH603
A	GLY173

---

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO A 503

Chain	Residue
A	GLN177
A	GLU181
A	HOH624
A	HOH641

---

site_id	AC4
Number of Residues	1
Details	binding site for residue EDO A 504

Chain	Residue
A	HOH619

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO A 505

Chain	Residue
A	HIS248
A	LYS309
A	LEU374

---

site_id	AC6
Number of Residues	3
Details	binding site for residue EDO A 506

Chain	Residue
A	PRO191
A	GLU269
A	LYS271

---

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO A 507

Chain	Residue
A	LEU139
A	GLY216
A	THR217
A	HOH672

---

site_id	AC8
Number of Residues	14
Details	binding site for residue Q7Q A 508

Chain	Residue
A	LYS141
A	GLY142
A	ALA160
A	LYS162
A	LEU208
A	LEU210
A	GLU211
A	TYR212
A	ALA213
A	THR217
A	ASN261
A	LEU263
A	ALA273
A	PHE275

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGKFGNVYlArekqskfi..........LALK

Chain	Residue	Details
A	LEU139-LYS162

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDIKpeNLLL

Chain	Residue	Details
A	VAL252-LEU264

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027, ECO:0000269|PubMed:14580337

Chain	Residue	Details
A	ASP256

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X

Chain	Residue	Details
A	LYS143
A	LYS162
A	GLU211
A	GLU260
A	ASP274

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:14580337, ECO:0000269|PubMed:19668197

Chain	Residue	Details
A	THR287

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14580337, ECO:0000269|PubMed:16246726, ECO:0000269|PubMed:18662907, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:26246606

Chain	Residue	Details
A	THR288

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKA and PAK => ECO:0000269|PubMed:16246726

Chain	Residue	Details
A	SER342

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS258

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