Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6Z4I

A4V mutant of human SOD1 bound with benzyl benzoisoselenazolone derivative 3 in P21 space group

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000302	biological_process	response to reactive oxygen species
AAA	0000303	biological_process	response to superoxide
AAA	0001541	biological_process	ovarian follicle development
AAA	0001819	biological_process	positive regulation of cytokine production
AAA	0001890	biological_process	placenta development
AAA	0001895	biological_process	retina homeostasis
AAA	0002262	biological_process	myeloid cell homeostasis
AAA	0004784	molecular_function	superoxide dismutase activity
AAA	0005507	molecular_function	copper ion binding
AAA	0005515	molecular_function	protein binding
AAA	0005576	cellular_component	extracellular region
AAA	0005615	cellular_component	extracellular space
AAA	0005634	cellular_component	nucleus
AAA	0005654	cellular_component	nucleoplasm
AAA	0005737	cellular_component	cytoplasm
AAA	0005739	cellular_component	mitochondrion
AAA	0005758	cellular_component	mitochondrial intermembrane space
AAA	0005759	cellular_component	mitochondrial matrix
AAA	0005777	cellular_component	peroxisome
AAA	0005829	cellular_component	cytosol
AAA	0005886	cellular_component	plasma membrane
AAA	0006749	biological_process	glutathione metabolic process
AAA	0006801	biological_process	superoxide metabolic process
AAA	0006879	biological_process	intracellular iron ion homeostasis
AAA	0006915	biological_process	apoptotic process
AAA	0006979	biological_process	response to oxidative stress
AAA	0007283	biological_process	spermatogenesis
AAA	0007566	biological_process	embryo implantation
AAA	0007605	biological_process	sensory perception of sound
AAA	0007626	biological_process	locomotory behavior
AAA	0008089	biological_process	anterograde axonal transport
AAA	0008090	biological_process	retrograde axonal transport
AAA	0008217	biological_process	regulation of blood pressure
AAA	0008270	molecular_function	zinc ion binding
AAA	0008340	biological_process	determination of adult lifespan
AAA	0009408	biological_process	response to heat
AAA	0009410	biological_process	response to xenobiotic stimulus
AAA	0010467	biological_process	gene expression
AAA	0016209	molecular_function	antioxidant activity
AAA	0016491	molecular_function	oxidoreductase activity
AAA	0019226	biological_process	transmission of nerve impulse
AAA	0019228	biological_process	neuronal action potential
AAA	0019430	biological_process	removal of superoxide radicals
AAA	0030346	molecular_function	protein phosphatase 2B binding
AAA	0031267	molecular_function	small GTPase binding
AAA	0031410	cellular_component	cytoplasmic vesicle
AAA	0032287	biological_process	peripheral nervous system myelin maintenance
AAA	0032839	cellular_component	dendrite cytoplasm
AAA	0032930	biological_process	positive regulation of superoxide anion generation
AAA	0032991	cellular_component	protein-containing complex
AAA	0033081	biological_process	regulation of T cell differentiation in thymus
AAA	0035234	biological_process	ectopic germ cell programmed cell death
AAA	0040014	biological_process	regulation of multicellular organism growth
AAA	0042542	biological_process	response to hydrogen peroxide
AAA	0042554	biological_process	superoxide anion generation
AAA	0042802	molecular_function	identical protein binding
AAA	0042803	molecular_function	protein homodimerization activity
AAA	0043025	cellular_component	neuronal cell body
AAA	0043065	biological_process	positive regulation of apoptotic process
AAA	0043066	biological_process	negative regulation of apoptotic process
AAA	0043087	biological_process	regulation of GTPase activity
AAA	0043410	biological_process	positive regulation of MAPK cascade
AAA	0043524	biological_process	negative regulation of neuron apoptotic process
AAA	0045471	biological_process	response to ethanol
AAA	0046620	biological_process	regulation of organ growth
AAA	0046716	biological_process	muscle cell cellular homeostasis
AAA	0046872	molecular_function	metal ion binding
AAA	0048538	biological_process	thymus development
AAA	0048678	biological_process	response to axon injury
AAA	0050665	biological_process	hydrogen peroxide biosynthetic process
AAA	0050728	biological_process	negative regulation of inflammatory response
AAA	0050766	biological_process	positive regulation of phagocytosis
AAA	0051087	molecular_function	protein-folding chaperone binding
AAA	0051093	biological_process	negative regulation of developmental process
AAA	0051881	biological_process	regulation of mitochondrial membrane potential
AAA	0060047	biological_process	heart contraction
AAA	0060052	biological_process	neurofilament cytoskeleton organization
AAA	0060087	biological_process	relaxation of vascular associated smooth muscle
AAA	0060088	biological_process	auditory receptor cell stereocilium organization
AAA	0070062	cellular_component	extracellular exosome
AAA	0072593	biological_process	reactive oxygen species metabolic process
AAA	0099610	biological_process	action potential initiation
AAA	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
AAA	1904115	cellular_component	axon cytoplasm
AAA	2000242	biological_process	negative regulation of reproductive process
FFF	0000302	biological_process	response to reactive oxygen species
FFF	0000303	biological_process	response to superoxide
FFF	0001541	biological_process	ovarian follicle development
FFF	0001819	biological_process	positive regulation of cytokine production
FFF	0001890	biological_process	placenta development
FFF	0001895	biological_process	retina homeostasis
FFF	0002262	biological_process	myeloid cell homeostasis
FFF	0004784	molecular_function	superoxide dismutase activity
FFF	0005507	molecular_function	copper ion binding
FFF	0005515	molecular_function	protein binding
FFF	0005576	cellular_component	extracellular region
FFF	0005615	cellular_component	extracellular space
FFF	0005634	cellular_component	nucleus
FFF	0005654	cellular_component	nucleoplasm
FFF	0005737	cellular_component	cytoplasm
FFF	0005739	cellular_component	mitochondrion
FFF	0005758	cellular_component	mitochondrial intermembrane space
FFF	0005759	cellular_component	mitochondrial matrix
FFF	0005777	cellular_component	peroxisome
FFF	0005829	cellular_component	cytosol
FFF	0005886	cellular_component	plasma membrane
FFF	0006749	biological_process	glutathione metabolic process
FFF	0006801	biological_process	superoxide metabolic process
FFF	0006879	biological_process	intracellular iron ion homeostasis
FFF	0006915	biological_process	apoptotic process
FFF	0006979	biological_process	response to oxidative stress
FFF	0007283	biological_process	spermatogenesis
FFF	0007566	biological_process	embryo implantation
FFF	0007605	biological_process	sensory perception of sound
FFF	0007626	biological_process	locomotory behavior
FFF	0008089	biological_process	anterograde axonal transport
FFF	0008090	biological_process	retrograde axonal transport
FFF	0008217	biological_process	regulation of blood pressure
FFF	0008270	molecular_function	zinc ion binding
FFF	0008340	biological_process	determination of adult lifespan
FFF	0009408	biological_process	response to heat
FFF	0009410	biological_process	response to xenobiotic stimulus
FFF	0010467	biological_process	gene expression
FFF	0016209	molecular_function	antioxidant activity
FFF	0016491	molecular_function	oxidoreductase activity
FFF	0019226	biological_process	transmission of nerve impulse
FFF	0019228	biological_process	neuronal action potential
FFF	0019430	biological_process	removal of superoxide radicals
FFF	0030346	molecular_function	protein phosphatase 2B binding
FFF	0031267	molecular_function	small GTPase binding
FFF	0031410	cellular_component	cytoplasmic vesicle
FFF	0032287	biological_process	peripheral nervous system myelin maintenance
FFF	0032839	cellular_component	dendrite cytoplasm
FFF	0032930	biological_process	positive regulation of superoxide anion generation
FFF	0032991	cellular_component	protein-containing complex
FFF	0033081	biological_process	regulation of T cell differentiation in thymus
FFF	0035234	biological_process	ectopic germ cell programmed cell death
FFF	0040014	biological_process	regulation of multicellular organism growth
FFF	0042542	biological_process	response to hydrogen peroxide
FFF	0042554	biological_process	superoxide anion generation
FFF	0042802	molecular_function	identical protein binding
FFF	0042803	molecular_function	protein homodimerization activity
FFF	0043025	cellular_component	neuronal cell body
FFF	0043065	biological_process	positive regulation of apoptotic process
FFF	0043066	biological_process	negative regulation of apoptotic process
FFF	0043087	biological_process	regulation of GTPase activity
FFF	0043410	biological_process	positive regulation of MAPK cascade
FFF	0043524	biological_process	negative regulation of neuron apoptotic process
FFF	0045471	biological_process	response to ethanol
FFF	0046620	biological_process	regulation of organ growth
FFF	0046716	biological_process	muscle cell cellular homeostasis
FFF	0046872	molecular_function	metal ion binding
FFF	0048538	biological_process	thymus development
FFF	0048678	biological_process	response to axon injury
FFF	0050665	biological_process	hydrogen peroxide biosynthetic process
FFF	0050728	biological_process	negative regulation of inflammatory response
FFF	0050766	biological_process	positive regulation of phagocytosis
FFF	0051087	molecular_function	protein-folding chaperone binding
FFF	0051093	biological_process	negative regulation of developmental process
FFF	0051881	biological_process	regulation of mitochondrial membrane potential
FFF	0060047	biological_process	heart contraction
FFF	0060052	biological_process	neurofilament cytoskeleton organization
FFF	0060087	biological_process	relaxation of vascular associated smooth muscle
FFF	0060088	biological_process	auditory receptor cell stereocilium organization
FFF	0070062	cellular_component	extracellular exosome
FFF	0072593	biological_process	reactive oxygen species metabolic process
FFF	0099610	biological_process	action potential initiation
FFF	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
FFF	1904115	cellular_component	axon cytoplasm
FFF	2000242	biological_process	negative regulation of reproductive process

Functional Information from PROSITE/UniProt

site_id	PS00087
Number of Residues	11
Details	SOD_CU_ZN_1 Copper/Zinc superoxide dismutase signature 1. GFHVHEfGDnT

Chain	Residue	Details
AAA	GLY44-THR54

site_id	PS00332
Number of Residues	12
Details	SOD_CU_ZN_2 Copper/Zinc superoxide dismutase signature 2. GNAGsRlACgvI

Chain	Residue	Details
AAA	GLY138-ILE149

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:12963370, ECO:0000269\|PubMed:17548825

Chain	Residue	Details
AAA	HIS46
AAA	HIS48
AAA	HIS120
FFF	HIS46
FFF	HIS48
FFF	HIS120

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:20727846

Chain	Residue	Details
AAA	HIS63
AAA	HIS71
AAA	HIS80
AAA	ASP83
FFF	HIS63
FFF	HIS71
FFF	HIS80
FFF	ASP83

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N-acetylalanine => ECO:0000269\|PubMed:1463506, ECO:0000269\|PubMed:7002610, ECO:0007744\|PubMed:25944712

Chain	Residue	Details
AAA	ALA1
FFF	ALA1

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:P08228

Chain	Residue	Details
AAA	LYS3
AAA	LYS9
AAA	LYS91
FFF	LYS3
FFF	LYS9
FFF	LYS91

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
AAA	SER98
FFF	SER98

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
AAA	SER102
FFF	SER102

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P07632

Chain	Residue	Details
AAA	SER105
FFF	SER105

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P08228

Chain	Residue	Details
AAA	SER107
FFF	SER107

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269\|PubMed:24140062

Chain	Residue	Details
AAA	LYS122
FFF	LYS122

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P08228

Chain	Residue	Details
AAA	LYS136
FFF	LYS136

site_id	SWS_FT_FI11
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000269\|PubMed:22496122

Chain	Residue	Details
AAA	CYS6
FFF	CYS6

site_id	SWS_FT_FI12
Number of Residues	4
Details	CROSSLNK: 1-(tryptophan-3-yl)-tryptophan (Trp-Trp) (interchain with W-33) => ECO:0000269\|PubMed:20600836

Chain	Residue	Details
AAA	TRP32
FFF	TRP32

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)