Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6Z47

Smooth muscle myosin shutdown state heads region

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000146	molecular_function	microfilament motor activity
A	0000166	molecular_function	nucleotide binding
A	0003774	molecular_function	cytoskeletal motor activity
A	0003779	molecular_function	actin binding
A	0005516	molecular_function	calmodulin binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0016459	cellular_component	myosin complex
A	0016460	cellular_component	myosin II complex
A	0030016	cellular_component	myofibril
A	0031032	biological_process	actomyosin structure organization
A	0032982	cellular_component	myosin filament
A	0043531	molecular_function	ADP binding
A	0046872	molecular_function	metal ion binding
A	0051015	molecular_function	actin filament binding
A	0097435	biological_process	supramolecular fiber organization
A	0099512	cellular_component	supramolecular fiber
B	0000146	molecular_function	microfilament motor activity
B	0000166	molecular_function	nucleotide binding
B	0003774	molecular_function	cytoskeletal motor activity
B	0003779	molecular_function	actin binding
B	0005516	molecular_function	calmodulin binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0016459	cellular_component	myosin complex
B	0016460	cellular_component	myosin II complex
B	0030016	cellular_component	myofibril
B	0031032	biological_process	actomyosin structure organization
B	0032982	cellular_component	myosin filament
B	0043531	molecular_function	ADP binding
B	0046872	molecular_function	metal ion binding
B	0051015	molecular_function	actin filament binding
B	0097435	biological_process	supramolecular fiber organization
B	0099512	cellular_component	supramolecular fiber
C	0005509	molecular_function	calcium ion binding
C	0005829	cellular_component	cytosol
C	0008307	molecular_function	structural constituent of muscle
C	0016459	cellular_component	myosin complex
C	0016460	cellular_component	myosin II complex
D	0005509	molecular_function	calcium ion binding
D	0005829	cellular_component	cytosol
D	0008307	molecular_function	structural constituent of muscle
D	0016459	cellular_component	myosin complex
D	0016460	cellular_component	myosin II complex
E	0005509	molecular_function	calcium ion binding
E	0046872	molecular_function	metal ion binding
F	0005509	molecular_function	calcium ion binding
F	0046872	molecular_function	metal ion binding
G	0000146	molecular_function	microfilament motor activity
G	0000166	molecular_function	nucleotide binding
G	0003774	molecular_function	cytoskeletal motor activity
G	0003779	molecular_function	actin binding
G	0005516	molecular_function	calmodulin binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0016459	cellular_component	myosin complex
G	0016460	cellular_component	myosin II complex
G	0030016	cellular_component	myofibril
G	0031032	biological_process	actomyosin structure organization
G	0032982	cellular_component	myosin filament
G	0043531	molecular_function	ADP binding
G	0046872	molecular_function	metal ion binding
G	0051015	molecular_function	actin filament binding
G	0097435	biological_process	supramolecular fiber organization
G	0099512	cellular_component	supramolecular fiber
H	0000146	molecular_function	microfilament motor activity
H	0000166	molecular_function	nucleotide binding
H	0003774	molecular_function	cytoskeletal motor activity
H	0003779	molecular_function	actin binding
H	0005516	molecular_function	calmodulin binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0016459	cellular_component	myosin complex
H	0016460	cellular_component	myosin II complex
H	0030016	cellular_component	myofibril
H	0031032	biological_process	actomyosin structure organization
H	0032982	cellular_component	myosin filament
H	0043531	molecular_function	ADP binding
H	0046872	molecular_function	metal ion binding
H	0051015	molecular_function	actin filament binding
H	0097435	biological_process	supramolecular fiber organization
H	0099512	cellular_component	supramolecular fiber

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG A 2001

Chain	Residue
A	THR184
A	SER246
A	ADP2002
A	PO42003

site_id	AC2
Number of Residues	18
Details	binding site for residue ADP A 2002

Chain	Residue
A	TYR133
A	GLU178
A	SER179
A	GLY180
A	ALA181
A	GLY182
A	LYS183
A	THR184
A	GLU185
A	ASN242
A	ASN244
A	MG2001
A	PO42003
A	ILE113
A	ASN125
A	PRO126
A	TYR127
A	LYS128

site_id	AC3
Number of Residues	9
Details	binding site for residue PO4 A 2003

Chain	Residue
A	GLU178
A	SER179
A	LYS183
A	ASN242
A	SER245
A	SER246
A	GLY468
A	MG2001
A	ADP2002

site_id	AC4
Number of Residues	5
Details	binding site for residue MG B 2001

Chain	Residue
B	THR184
B	ASN244
B	SER246
B	ADP2002
B	PO42003

site_id	AC5
Number of Residues	14
Details	binding site for residue ADP B 2002

Chain	Residue
B	ASN125
B	PRO126
B	LYS128
B	TYR133
B	SER179
B	ALA181
B	GLY182
B	LYS183
B	THR184
B	GLU185
B	ASN242
B	ASN244
B	MG2001
B	PO42003

site_id	AC6
Number of Residues	9
Details	binding site for residue PO4 B 2003

Chain	Residue
B	SER179
B	LYS183
B	THR184
B	ASN242
B	ASN244
B	SER245
B	SER246
B	MG2001
B	ADP2002

site_id	AC7
Number of Residues	5
Details	binding site for residue MG E 201

Chain	Residue
E	ASP42
E	ASN44
E	ASP46
E	PHE48
E	ASP53

site_id	AC8
Number of Residues	5
Details	binding site for residue MG F 201

Chain	Residue
F	ASP42
F	ASN44
F	ASP46
F	PHE48
F	ASP53

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DQNRDGFIDkeDL

Chain	Residue	Details
E	ASP42-LEU54

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)