6Z3Z
CryoEM structure of horse sodium/proton exchanger NHE9 without C-terminal regulatory domain in an inward-facing conformation
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006812 | biological_process | monoatomic cation transport |
A | 0006814 | biological_process | sodium ion transport |
A | 0006885 | biological_process | regulation of pH |
A | 0015297 | molecular_function | antiporter activity |
A | 0015385 | molecular_function | sodium:proton antiporter activity |
A | 0016020 | cellular_component | membrane |
A | 0055085 | biological_process | transmembrane transport |
A | 1902600 | biological_process | proton transmembrane transport |
B | 0006812 | biological_process | monoatomic cation transport |
B | 0006814 | biological_process | sodium ion transport |
B | 0006885 | biological_process | regulation of pH |
B | 0015297 | molecular_function | antiporter activity |
B | 0015385 | molecular_function | sodium:proton antiporter activity |
B | 0016020 | cellular_component | membrane |
B | 0055085 | biological_process | transmembrane transport |
B | 1902600 | biological_process | proton transmembrane transport |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
Chain | Residue | Details |
B | ALA21-PHE41 | |
A | ALA21-PHE41 |
site_id | SWS_FT_FI2 |
Number of Residues | 144 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:33118634 |
Chain | Residue | Details |
B | LYS42-ARG45 | |
A | LEU299-LYS301 | |
A | THR344-LEU364 | |
A | ARG408-TRP429 | |
B | TYR148-THR164 | |
B | GLU225-LEU235 | |
B | LEU299-LYS301 | |
B | THR344-LEU364 | |
B | ARG408-TRP429 | |
A | LYS42-ARG45 | |
A | TYR148-THR164 | |
A | GLU225-LEU235 |
site_id | SWS_FT_FI3 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
Chain | Residue | Details |
B | PHE46-LEU66 | |
A | PHE46-LEU66 |
site_id | SWS_FT_FI4 |
Number of Residues | 222 |
Details | TOPO_DOM: Lumenal => ECO:0000305|PubMed:33118634 |
Chain | Residue | Details |
B | ARG67-LYS126 | |
A | ARG451-THR465 | |
B | LYS186-ASP203 | |
B | TYR257-ASN277 | |
B | THR386 | |
B | ARG451-THR465 | |
A | ARG67-LYS126 | |
A | LYS186-ASP203 | |
A | TYR257-ASN277 | |
A | THR386 |
site_id | SWS_FT_FI5 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
Chain | Residue | Details |
B | MET127-GLY147 | |
A | MET127-GLY147 |
site_id | SWS_FT_FI6 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
Chain | Residue | Details |
B | TYR165-VAL185 | |
A | TYR165-VAL185 |
site_id | SWS_FT_FI7 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
Chain | Residue | Details |
B | CYS204-HIS224 | |
A | CYS204-HIS224 |
site_id | SWS_FT_FI8 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
Chain | Residue | Details |
B | LEU236-ILE256 | |
A | LEU236-ILE256 |
site_id | SWS_FT_FI9 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
Chain | Residue | Details |
B | PHE278-LEU298 | |
A | PHE278-LEU298 |
site_id | SWS_FT_FI10 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=8 => ECO:0000255 |
Chain | Residue | Details |
B | PHE302-SER322 | |
A | PHE302-SER322 |
site_id | SWS_FT_FI11 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=9 => ECO:0000255 |
Chain | Residue | Details |
B | ALA323-VAL343 | |
A | ALA323-VAL343 |
site_id | SWS_FT_FI12 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=100 => ECO:0000255 |
Chain | Residue | Details |
B | PHE365-PHE385 | |
A | PHE365-PHE385 |
site_id | SWS_FT_FI13 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=11 => ECO:0000255 |
Chain | Residue | Details |
B | PHE387-ALA407 | |
A | PHE387-ALA407 |
site_id | SWS_FT_FI14 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=12 => ECO:0000255 |
Chain | Residue | Details |
B | ASN430-ILE450 | |
A | ASN430-ILE450 |