Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6Z1U

bovine ATP synthase F1c8-peripheral stalk domain, state 3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005886	cellular_component	plasma membrane
A	0006754	biological_process	ATP biosynthetic process
A	0006811	biological_process	monoatomic ion transport
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0016020	cellular_component	membrane
A	0032559	molecular_function	adenyl ribonucleotide binding
A	0043531	molecular_function	ADP binding
A	0045259	cellular_component	proton-transporting ATP synthase complex
A	0046034	biological_process	ATP metabolic process
A	0046872	molecular_function	metal ion binding
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005886	cellular_component	plasma membrane
B	0006754	biological_process	ATP biosynthetic process
B	0006811	biological_process	monoatomic ion transport
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0016020	cellular_component	membrane
B	0032559	molecular_function	adenyl ribonucleotide binding
B	0043531	molecular_function	ADP binding
B	0045259	cellular_component	proton-transporting ATP synthase complex
B	0046034	biological_process	ATP metabolic process
B	0046872	molecular_function	metal ion binding
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0000166	molecular_function	nucleotide binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005886	cellular_component	plasma membrane
C	0006754	biological_process	ATP biosynthetic process
C	0006811	biological_process	monoatomic ion transport
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0016020	cellular_component	membrane
C	0032559	molecular_function	adenyl ribonucleotide binding
C	0043531	molecular_function	ADP binding
C	0045259	cellular_component	proton-transporting ATP synthase complex
C	0046034	biological_process	ATP metabolic process
C	0046872	molecular_function	metal ion binding
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0000166	molecular_function	nucleotide binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0006754	biological_process	ATP biosynthetic process
D	0006811	biological_process	monoatomic ion transport
D	0015986	biological_process	proton motive force-driven ATP synthesis
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
D	0045259	cellular_component	proton-transporting ATP synthase complex
D	0046034	biological_process	ATP metabolic process
D	0046872	molecular_function	metal ion binding
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0000166	molecular_function	nucleotide binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0006754	biological_process	ATP biosynthetic process
E	0006811	biological_process	monoatomic ion transport
E	0015986	biological_process	proton motive force-driven ATP synthesis
E	0016020	cellular_component	membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
E	0045259	cellular_component	proton-transporting ATP synthase complex
E	0046034	biological_process	ATP metabolic process
E	0046872	molecular_function	metal ion binding
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0000166	molecular_function	nucleotide binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0006754	biological_process	ATP biosynthetic process
F	0006811	biological_process	monoatomic ion transport
F	0015986	biological_process	proton motive force-driven ATP synthesis
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
F	0045259	cellular_component	proton-transporting ATP synthase complex
F	0046034	biological_process	ATP metabolic process
F	0046872	molecular_function	metal ion binding
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0006754	biological_process	ATP biosynthetic process
G	0006811	biological_process	monoatomic ion transport
G	0015986	biological_process	proton motive force-driven ATP synthesis
G	0016020	cellular_component	membrane
G	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
G	0045259	cellular_component	proton-transporting ATP synthase complex
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
H	0015986	biological_process	proton motive force-driven ATP synthesis
H	0045259	cellular_component	proton-transporting ATP synthase complex
H	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0006754	biological_process	ATP biosynthetic process
I	0006811	biological_process	monoatomic ion transport
I	0015986	biological_process	proton motive force-driven ATP synthesis
I	0016020	cellular_component	membrane
I	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
I	0045259	cellular_component	proton-transporting ATP synthase complex
I	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
I	1902600	biological_process	proton transmembrane transport
J	0005739	cellular_component	mitochondrion
J	0032780	biological_process	negative regulation of ATP-dependent activity
J	0042030	molecular_function	ATPase inhibitor activity
K	0015078	molecular_function	proton transmembrane transporter activity
K	0015986	biological_process	proton motive force-driven ATP synthesis
K	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
K	0045259	cellular_component	proton-transporting ATP synthase complex
K	1902600	biological_process	proton transmembrane transport
L	0015078	molecular_function	proton transmembrane transporter activity
L	0015986	biological_process	proton motive force-driven ATP synthesis
L	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
L	0045259	cellular_component	proton-transporting ATP synthase complex
L	1902600	biological_process	proton transmembrane transport
M	0015078	molecular_function	proton transmembrane transporter activity
M	0015986	biological_process	proton motive force-driven ATP synthesis
M	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
M	0045259	cellular_component	proton-transporting ATP synthase complex
M	1902600	biological_process	proton transmembrane transport
N	0015078	molecular_function	proton transmembrane transporter activity
N	0015986	biological_process	proton motive force-driven ATP synthesis
N	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
N	0045259	cellular_component	proton-transporting ATP synthase complex
N	1902600	biological_process	proton transmembrane transport
O	0015078	molecular_function	proton transmembrane transporter activity
O	0015986	biological_process	proton motive force-driven ATP synthesis
O	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
O	0045259	cellular_component	proton-transporting ATP synthase complex
O	1902600	biological_process	proton transmembrane transport
P	0015078	molecular_function	proton transmembrane transporter activity
P	0015986	biological_process	proton motive force-driven ATP synthesis
P	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
P	0045259	cellular_component	proton-transporting ATP synthase complex
P	1902600	biological_process	proton transmembrane transport
Q	0015078	molecular_function	proton transmembrane transporter activity
Q	0015986	biological_process	proton motive force-driven ATP synthesis
Q	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
Q	0045259	cellular_component	proton-transporting ATP synthase complex
Q	1902600	biological_process	proton transmembrane transport
R	0015078	molecular_function	proton transmembrane transporter activity
R	0015986	biological_process	proton motive force-driven ATP synthesis
R	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
R	0045259	cellular_component	proton-transporting ATP synthase complex
R	1902600	biological_process	proton transmembrane transport
S	0015986	biological_process	proton motive force-driven ATP synthesis
S	0016020	cellular_component	membrane
S	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
b	0015078	molecular_function	proton transmembrane transporter activity
b	0015986	biological_process	proton motive force-driven ATP synthesis
h	0015078	molecular_function	proton transmembrane transporter activity
h	0015986	biological_process	proton motive force-driven ATP synthesis
h	0045259	cellular_component	proton-transporting ATP synthase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue ATP A 600

Chain	Residue
A	GLN172
A	GLY431
A	GLN432
A	MG601
A	HOH702
A	HOH703
D	TYR372
A	THR173
A	GLY174
A	LYS175
A	THR176
A	SER177
A	PHE357
A	ARG362
A	GLN430

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 601

Chain	Residue
A	THR176
A	ATP600
A	HOH701
A	HOH702
A	HOH703

site_id	AC3
Number of Residues	17
Details	binding site for residue ATP B 600

Chain	Residue
B	GLN172
B	THR173
B	GLY174
B	LYS175
B	THR176
B	SER177
B	GLU328
B	PHE357
B	ARG362
B	GLN430
B	GLY431
B	GLN432
B	MG601
B	HOH701
B	HOH702
E	ARG360
E	ASP363

site_id	AC4
Number of Residues	5
Details	binding site for residue MG B 601

Chain	Residue
B	THR176
B	ATP600
B	HOH701
B	HOH702
B	HOH703

site_id	AC5
Number of Residues	18
Details	binding site for residue ATP C 600

Chain	Residue
C	GLN172
C	THR173
C	GLY174
C	LYS175
C	THR176
C	SER177
C	GLU328
C	ARG362
C	PRO363
C	GLN430
C	GLY431
C	GLN432
C	MG601
C	HOH701
C	HOH702
C	HOH703
F	ARG360
F	TYR372

site_id	AC6
Number of Residues	5
Details	binding site for residue MG C 601

Chain	Residue
C	THR176
C	ATP600
C	HOH701
C	HOH702
C	HOH703

site_id	AC7
Number of Residues	13
Details	binding site for residue ADP D 600

Chain	Residue
C	ARG373
D	ALA162
D	GLY163
D	GLY165
D	LYS166
D	THR167
D	VAL168
D	TYR349
D	PHE422
D	THR429
D	MG601
D	HOH702
D	HOH704

site_id	AC8
Number of Residues	8
Details	binding site for residue MG D 601

Chain	Residue
D	THR167
D	GLU192
D	GLU196
D	ADP600
D	HOH701
D	HOH702
D	HOH703
D	HOH704

site_id	AC9
Number of Residues	10
Details	binding site for residue ADP E 600

Chain	Residue
E	ALA162
E	GLY163
E	VAL164
E	GLY165
E	LYS166
E	THR167
E	VAL168
E	TYR349
E	PHE422
E	PHE428

site_id	AD1
Number of Residues	13
Details	binding site for residue ADP F 600

Chain	Residue
F	VAL164
F	GLY165
F	LYS166
F	THR167
F	VAL168
F	TYR349
F	PHE422
F	MG601
F	HOH701
F	HOH702
B	ARG373
F	ALA162
F	GLY163

site_id	AD2
Number of Residues	9
Details	binding site for residue MG F 601

Chain	Residue
F	THR167
F	GLU192
F	ARG193
F	GLU196
F	ADP600
F	HOH701
F	HOH702
F	HOH703
F	HOH704

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAVDPLDSTS

Chain	Residue	Details
D	PRO350-SER359
A	PRO363-SER372

site_id	PS00153
Number of Residues	14
Details	ATPASE_GAMMA ATP synthase gamma subunit signature. ITkEliEiisGAaA

Chain	Residue	Details
G	ILE258-ALA271

site_id	PS00389
Number of Residues	20
Details	ATPASE_DELTA ATP synthase delta (OSCP) subunit signature. LkLevkIDpSImGGMIVRiG

Chain	Residue	Details
S	LEU148-GLY167

site_id	PS00605
Number of Residues	22
Details	ATPASE_C ATP synthase c subunit signature. ARNPslkqqLfSyaILgfaLsE

Chain	Residue	Details
K	ALA37-GLU58

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P18859

Chain	Residue	Details
h	LYS9
P	ILE51-ILE71
Q	VAL16-TYR36
Q	ILE51-ILE71
R	VAL16-TYR36
R	ILE51-ILE71
O	VAL16-TYR36
O	ILE51-ILE71
C	GLN172
C	GLY174
C	LYS175
h	LYS14
C	THR176
C	SER177
C	ASP269
C	GLN430
C	GLN432
h	LYS73
S	LYS50
S	LYS153
M	ILE51-ILE71
N	VAL16-TYR36
N	ILE51-ILE71
P	VAL16-TYR36

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P97450

Chain	Residue	Details
h	LYS47
b	LYS112
b	LYS120
b	LYS202
P	GLU58
Q	GLU58
R	GLU58
O	GLU58

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P97450

Chain	Residue	Details
h	LYS52
h	LYS67
S	LYS139
N	M3L43
P	M3L43
Q	M3L43
R	M3L43
O	M3L43

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P21571

Chain	Residue	Details
h	SER76
E	LYS476
F	LYS78
F	LYS115
F	LYS213
F	LYS218
F	LYS476
S	LYS169
D	LYS213
D	LYS218
D	LYS476
E	LYS78
E	LYS115
E	LYS213
E	LYS218

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P36542

Chain	Residue	Details
G	SER121
D	LYS380
E	LYS152
E	LYS380
F	LYS152
F	LYS380

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P56480

Chain	Residue	Details
D	THR266
E	THR266
F	THR266

site_id	SWS_FT_FI7
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P06576

Chain	Residue	Details
D	SER369
B	LYS498
C	LYS80
C	LYS83
C	LYS89
C	LYS197
C	LYS498
E	SER369
F	SER369
A	LYS197
A	LYS498
B	LYS80
B	LYS83
B	LYS89
B	LYS197

site_id	SWS_FT_FI8
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P10719

Chain	Residue	Details
D	SER387
E	SER387
F	SER387

site_id	SWS_FT_FI9
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P56480

Chain	Residue	Details
D	LYS434
A	LYS488
A	LYS496
B	LYS118
B	LYS124
B	LYS187
B	LYS196
B	LYS218
B	LYS262
B	LYS384
B	LYS455
D	LYS439
B	LYS463
B	LYS488
B	LYS496
C	LYS118
C	LYS124
C	LYS187
C	LYS196
C	LYS218
C	LYS262
C	LYS384
E	LYS434
C	LYS455
C	LYS463
C	LYS488
C	LYS496
E	LYS439
F	LYS434
F	LYS439
A	LYS384
A	LYS455
A	LYS463

site_id	SWS_FT_FI10
Number of Residues	3
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
D	SER60
E	SER60
F	SER60

site_id	SWS_FT_FI11
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P25705

Chain	Residue	Details
A	LYS391
B	LYS391
C	LYS391

site_id	SWS_FT_FI12
Number of Residues	3
Details	CARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000250

Chain	Residue	Details
A	SER33
B	SER33
C	SER33

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 178

Chain	Residue	Details
D	LYS166	electrostatic stabiliser
D	GLU192	electrostatic stabiliser
D	ARG193	electrostatic stabiliser

site_id	MCSA2
Number of Residues	3
Details	M-CSA 178

Chain	Residue	Details
E	LYS166	electrostatic stabiliser
E	GLU192	electrostatic stabiliser
E	ARG193	electrostatic stabiliser

site_id	MCSA3
Number of Residues	3
Details	M-CSA 178

Chain	Residue	Details
F	LYS166	electrostatic stabiliser
F	GLU192	electrostatic stabiliser
F	ARG193	electrostatic stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)