6Z0V

CryoEM structure of the Chikungunya virus nsP1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0006396	biological_process	RNA processing
A	0008174	molecular_function	mRNA methyltransferase activity
A	0016556	biological_process	mRNA modification
C	0003723	molecular_function	RNA binding
C	0006396	biological_process	RNA processing
C	0008174	molecular_function	mRNA methyltransferase activity
C	0016556	biological_process	mRNA modification
E	0003723	molecular_function	RNA binding
E	0006396	biological_process	RNA processing
E	0008174	molecular_function	mRNA methyltransferase activity
E	0016556	biological_process	mRNA modification
G	0003723	molecular_function	RNA binding
G	0006396	biological_process	RNA processing
G	0008174	molecular_function	mRNA methyltransferase activity
G	0016556	biological_process	mRNA modification
I	0003723	molecular_function	RNA binding
I	0006396	biological_process	RNA processing
I	0008174	molecular_function	mRNA methyltransferase activity
I	0016556	biological_process	mRNA modification
K	0003723	molecular_function	RNA binding
K	0006396	biological_process	RNA processing
K	0008174	molecular_function	mRNA methyltransferase activity
K	0016556	biological_process	mRNA modification
M	0003723	molecular_function	RNA binding
M	0006396	biological_process	RNA processing
M	0008174	molecular_function	mRNA methyltransferase activity
M	0016556	biological_process	mRNA modification
O	0003723	molecular_function	RNA binding
O	0006396	biological_process	RNA processing
O	0008174	molecular_function	mRNA methyltransferase activity
O	0016556	biological_process	mRNA modification
Q	0003723	molecular_function	RNA binding
Q	0006396	biological_process	RNA processing
Q	0008174	molecular_function	mRNA methyltransferase activity
Q	0016556	biological_process	mRNA modification
S	0003723	molecular_function	RNA binding
S	0006396	biological_process	RNA processing
S	0008174	molecular_function	mRNA methyltransferase activity
S	0016556	biological_process	mRNA modification
V	0003723	molecular_function	RNA binding
V	0006396	biological_process	RNA processing
V	0008174	molecular_function	mRNA methyltransferase activity
V	0016556	biological_process	mRNA modification
X	0003723	molecular_function	RNA binding
X	0006396	biological_process	RNA processing
X	0008174	molecular_function	mRNA methyltransferase activity
X	0016556	biological_process	mRNA modification

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN A 1001

Chain	Residue
A	HIS79
A	VAL81
A	GLU129
A	CYS134
A	CYS141

---

site_id	AC2
Number of Residues	5
Details	binding site for residue ZN C 1001

Chain	Residue
C	CYS141
C	HIS79
C	VAL81
C	GLU129
C	CYS134

---

site_id	AC3
Number of Residues	5
Details	binding site for residue ZN E 1001

Chain	Residue
E	HIS79
E	VAL81
E	GLU129
E	CYS134
E	CYS141

---

site_id	AC4
Number of Residues	5
Details	binding site for residue ZN G 1001

Chain	Residue
G	HIS79
G	VAL81
G	GLU129
G	CYS134
G	CYS141

---

site_id	AC5
Number of Residues	5
Details	binding site for residue ZN I 1001

Chain	Residue
I	HIS79
I	VAL81
I	GLU129
I	CYS134
I	CYS141

---

site_id	AC6
Number of Residues	5
Details	binding site for residue ZN K 1001

Chain	Residue
K	HIS79
K	VAL81
K	GLU129
K	CYS134
K	CYS141

---

site_id	AC7
Number of Residues	5
Details	binding site for residue ZN M 1001

Chain	Residue
M	HIS79
M	VAL81
M	GLU129
M	CYS134
M	CYS141

---

site_id	AC8
Number of Residues	5
Details	binding site for residue ZN O 1001

Chain	Residue
O	HIS79
O	VAL81
O	GLU129
O	CYS134
O	CYS141

---

site_id	AC9
Number of Residues	5
Details	binding site for residue ZN Q 1001

Chain	Residue
Q	HIS79
Q	VAL81
Q	GLU129
Q	CYS134
Q	CYS141

---

site_id	AD1
Number of Residues	5
Details	binding site for residue ZN S 1001

Chain	Residue
S	HIS79
S	VAL81
S	GLU129
S	CYS134
S	CYS141

---

site_id	AD2
Number of Residues	5
Details	binding site for residue ZN V 1001

Chain	Residue
V	HIS79
V	VAL81
V	GLU129
V	CYS134
V	CYS141

---

site_id	AD3
Number of Residues	5
Details	binding site for residue ZN X 1001

Chain	Residue
X	HIS79
X	VAL81
X	GLU129
X	CYS134
X	CYS141

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2772
Details	Domain: {"description":"Alphavirus-like MT","evidences":[{"source":"PROSITE-ProRule","id":"PRU01079","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Active site: {"description":"For mRNA-capping enzyme nsP1 activity","evidences":[{"source":"PubMed","id":"33730549","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33730549","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Site: {"description":"Involved in the phosphoramide link with 7-methyl-GMP","evidences":[{"source":"UniProtKB","id":"P27282","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Lipidation: {"description":"S-palmitoyl cysteine; by host","evidences":[{"source":"PubMed","id":"30404808","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---