6Z0U
CryoEM structure of the Chikungunya virus nsP1 complex
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0006396 | biological_process | RNA processing |
| A | 0008174 | molecular_function | mRNA methyltransferase activity |
| A | 0016556 | biological_process | mRNA modification |
| BA | 0003723 | molecular_function | RNA binding |
| BA | 0006396 | biological_process | RNA processing |
| BA | 0008174 | molecular_function | mRNA methyltransferase activity |
| BA | 0016556 | biological_process | mRNA modification |
| C | 0003723 | molecular_function | RNA binding |
| C | 0006396 | biological_process | RNA processing |
| C | 0008174 | molecular_function | mRNA methyltransferase activity |
| C | 0016556 | biological_process | mRNA modification |
| DA | 0003723 | molecular_function | RNA binding |
| DA | 0006396 | biological_process | RNA processing |
| DA | 0008174 | molecular_function | mRNA methyltransferase activity |
| DA | 0016556 | biological_process | mRNA modification |
| E | 0003723 | molecular_function | RNA binding |
| E | 0006396 | biological_process | RNA processing |
| E | 0008174 | molecular_function | mRNA methyltransferase activity |
| E | 0016556 | biological_process | mRNA modification |
| FA | 0003723 | molecular_function | RNA binding |
| FA | 0006396 | biological_process | RNA processing |
| FA | 0008174 | molecular_function | mRNA methyltransferase activity |
| FA | 0016556 | biological_process | mRNA modification |
| G | 0003723 | molecular_function | RNA binding |
| G | 0006396 | biological_process | RNA processing |
| G | 0008174 | molecular_function | mRNA methyltransferase activity |
| G | 0016556 | biological_process | mRNA modification |
| HA | 0003723 | molecular_function | RNA binding |
| HA | 0006396 | biological_process | RNA processing |
| HA | 0008174 | molecular_function | mRNA methyltransferase activity |
| HA | 0016556 | biological_process | mRNA modification |
| I | 0003723 | molecular_function | RNA binding |
| I | 0006396 | biological_process | RNA processing |
| I | 0008174 | molecular_function | mRNA methyltransferase activity |
| I | 0016556 | biological_process | mRNA modification |
| JA | 0003723 | molecular_function | RNA binding |
| JA | 0006396 | biological_process | RNA processing |
| JA | 0008174 | molecular_function | mRNA methyltransferase activity |
| JA | 0016556 | biological_process | mRNA modification |
| K | 0003723 | molecular_function | RNA binding |
| K | 0006396 | biological_process | RNA processing |
| K | 0008174 | molecular_function | mRNA methyltransferase activity |
| K | 0016556 | biological_process | mRNA modification |
| LA | 0003723 | molecular_function | RNA binding |
| LA | 0006396 | biological_process | RNA processing |
| LA | 0008174 | molecular_function | mRNA methyltransferase activity |
| LA | 0016556 | biological_process | mRNA modification |
| M | 0003723 | molecular_function | RNA binding |
| M | 0006396 | biological_process | RNA processing |
| M | 0008174 | molecular_function | mRNA methyltransferase activity |
| M | 0016556 | biological_process | mRNA modification |
| NA | 0003723 | molecular_function | RNA binding |
| NA | 0006396 | biological_process | RNA processing |
| NA | 0008174 | molecular_function | mRNA methyltransferase activity |
| NA | 0016556 | biological_process | mRNA modification |
| O | 0003723 | molecular_function | RNA binding |
| O | 0006396 | biological_process | RNA processing |
| O | 0008174 | molecular_function | mRNA methyltransferase activity |
| O | 0016556 | biological_process | mRNA modification |
| PA | 0003723 | molecular_function | RNA binding |
| PA | 0006396 | biological_process | RNA processing |
| PA | 0008174 | molecular_function | mRNA methyltransferase activity |
| PA | 0016556 | biological_process | mRNA modification |
| Q | 0003723 | molecular_function | RNA binding |
| Q | 0006396 | biological_process | RNA processing |
| Q | 0008174 | molecular_function | mRNA methyltransferase activity |
| Q | 0016556 | biological_process | mRNA modification |
| RA | 0003723 | molecular_function | RNA binding |
| RA | 0006396 | biological_process | RNA processing |
| RA | 0008174 | molecular_function | mRNA methyltransferase activity |
| RA | 0016556 | biological_process | mRNA modification |
| S | 0003723 | molecular_function | RNA binding |
| S | 0006396 | biological_process | RNA processing |
| S | 0008174 | molecular_function | mRNA methyltransferase activity |
| S | 0016556 | biological_process | mRNA modification |
| TA | 0003723 | molecular_function | RNA binding |
| TA | 0006396 | biological_process | RNA processing |
| TA | 0008174 | molecular_function | mRNA methyltransferase activity |
| TA | 0016556 | biological_process | mRNA modification |
| V | 0003723 | molecular_function | RNA binding |
| V | 0006396 | biological_process | RNA processing |
| V | 0008174 | molecular_function | mRNA methyltransferase activity |
| V | 0016556 | biological_process | mRNA modification |
| VA | 0003723 | molecular_function | RNA binding |
| VA | 0006396 | biological_process | RNA processing |
| VA | 0008174 | molecular_function | mRNA methyltransferase activity |
| VA | 0016556 | biological_process | mRNA modification |
| X | 0003723 | molecular_function | RNA binding |
| X | 0006396 | biological_process | RNA processing |
| X | 0008174 | molecular_function | mRNA methyltransferase activity |
| X | 0016556 | biological_process | mRNA modification |
| Z | 0003723 | molecular_function | RNA binding |
| Z | 0006396 | biological_process | RNA processing |
| Z | 0008174 | molecular_function | mRNA methyltransferase activity |
| Z | 0016556 | biological_process | mRNA modification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1001 |
| Chain | Residue |
| A | HIS79 |
| A | GLU129 |
| A | CYS134 |
| A | CYS141 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 1001 |
| Chain | Residue |
| C | HIS79 |
| C | GLU129 |
| C | CYS134 |
| C | CYS141 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 1001 |
| Chain | Residue |
| E | GLU129 |
| E | CYS134 |
| E | CYS141 |
| E | HIS79 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN G 1001 |
| Chain | Residue |
| G | HIS79 |
| G | GLU129 |
| G | CYS134 |
| G | CYS141 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN I 1001 |
| Chain | Residue |
| I | HIS79 |
| I | GLU129 |
| I | CYS134 |
| I | CYS141 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN K 1001 |
| Chain | Residue |
| K | HIS79 |
| K | GLU129 |
| K | CYS134 |
| K | CYS141 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN M 1001 |
| Chain | Residue |
| M | HIS79 |
| M | GLU129 |
| M | CYS134 |
| M | CYS141 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN O 1001 |
| Chain | Residue |
| O | HIS79 |
| O | GLU129 |
| O | CYS134 |
| O | CYS141 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN Q 1001 |
| Chain | Residue |
| Q | HIS79 |
| Q | GLU129 |
| Q | CYS134 |
| Q | CYS141 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN S 1001 |
| Chain | Residue |
| S | HIS79 |
| S | GLU129 |
| S | CYS134 |
| S | CYS141 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN V 1001 |
| Chain | Residue |
| V | HIS79 |
| V | GLU129 |
| V | CYS134 |
| V | CYS141 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN X 1001 |
| Chain | Residue |
| X | HIS79 |
| X | GLU129 |
| X | CYS134 |
| X | CYS141 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN Z 1001 |
| Chain | Residue |
| Z | HIS79 |
| Z | GLU129 |
| Z | CYS134 |
| Z | CYS141 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN BA 1001 |
| Chain | Residue |
| BA | HIS79 |
| BA | GLU129 |
| BA | CYS134 |
| BA | CYS141 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN DA 1001 |
| Chain | Residue |
| DA | HIS79 |
| DA | GLU129 |
| DA | CYS134 |
| DA | CYS141 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN FA 1001 |
| Chain | Residue |
| FA | HIS79 |
| FA | GLU129 |
| FA | CYS134 |
| FA | CYS141 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN HA 1001 |
| Chain | Residue |
| HA | HIS79 |
| HA | GLU129 |
| HA | CYS134 |
| HA | CYS141 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN JA 1001 |
| Chain | Residue |
| JA | HIS79 |
| JA | GLU129 |
| JA | CYS134 |
| JA | CYS141 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN LA 1001 |
| Chain | Residue |
| LA | HIS79 |
| LA | GLU129 |
| LA | CYS134 |
| LA | CYS141 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN NA 1001 |
| Chain | Residue |
| NA | HIS79 |
| NA | GLU129 |
| NA | CYS134 |
| NA | CYS141 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN PA 1001 |
| Chain | Residue |
| PA | HIS79 |
| PA | GLU129 |
| PA | CYS134 |
| PA | CYS141 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN RA 1001 |
| Chain | Residue |
| RA | HIS79 |
| RA | GLU129 |
| RA | CYS134 |
| RA | CYS141 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN TA 1001 |
| Chain | Residue |
| TA | HIS79 |
| TA | GLU129 |
| TA | CYS134 |
| TA | CYS141 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN VA 1001 |
| Chain | Residue |
| VA | HIS79 |
| VA | GLU129 |
| VA | CYS134 |
| VA | CYS141 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | ACT_SITE: For mRNA-capping enzyme nsP1 activity => ECO:0000269|PubMed:33730549 |
| Chain | Residue | Details |
| A | HIS37 | |
| S | HIS37 | |
| V | HIS37 | |
| X | HIS37 | |
| Z | HIS37 | |
| BA | HIS37 | |
| DA | HIS37 | |
| FA | HIS37 | |
| HA | HIS37 | |
| JA | HIS37 | |
| LA | HIS37 | |
| C | HIS37 | |
| NA | HIS37 | |
| PA | HIS37 | |
| RA | HIS37 | |
| TA | HIS37 | |
| VA | HIS37 | |
| E | HIS37 | |
| G | HIS37 | |
| I | HIS37 | |
| K | HIS37 | |
| M | HIS37 | |
| O | HIS37 | |
| Q | HIS37 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 96 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33730549 |
| Chain | Residue | Details |
| A | HIS79 | |
| E | GLU129 | |
| E | CYS134 | |
| E | CYS141 | |
| G | HIS79 | |
| G | GLU129 | |
| G | CYS134 | |
| G | CYS141 | |
| I | HIS79 | |
| I | GLU129 | |
| I | CYS134 | |
| A | GLU129 | |
| I | CYS141 | |
| K | HIS79 | |
| K | GLU129 | |
| K | CYS134 | |
| K | CYS141 | |
| M | HIS79 | |
| M | GLU129 | |
| M | CYS134 | |
| M | CYS141 | |
| O | HIS79 | |
| A | CYS134 | |
| O | GLU129 | |
| O | CYS134 | |
| O | CYS141 | |
| Q | HIS79 | |
| Q | GLU129 | |
| Q | CYS134 | |
| Q | CYS141 | |
| S | HIS79 | |
| S | GLU129 | |
| S | CYS134 | |
| A | CYS141 | |
| S | CYS141 | |
| V | HIS79 | |
| V | GLU129 | |
| V | CYS134 | |
| V | CYS141 | |
| X | HIS79 | |
| X | GLU129 | |
| X | CYS134 | |
| X | CYS141 | |
| Z | HIS79 | |
| C | HIS79 | |
| Z | GLU129 | |
| Z | CYS134 | |
| Z | CYS141 | |
| BA | HIS79 | |
| BA | GLU129 | |
| BA | CYS134 | |
| BA | CYS141 | |
| DA | HIS79 | |
| DA | GLU129 | |
| DA | CYS134 | |
| C | GLU129 | |
| DA | CYS141 | |
| FA | HIS79 | |
| FA | GLU129 | |
| FA | CYS134 | |
| FA | CYS141 | |
| HA | HIS79 | |
| HA | GLU129 | |
| HA | CYS134 | |
| HA | CYS141 | |
| JA | HIS79 | |
| C | CYS134 | |
| JA | GLU129 | |
| JA | CYS134 | |
| JA | CYS141 | |
| LA | HIS79 | |
| LA | GLU129 | |
| LA | CYS134 | |
| LA | CYS141 | |
| NA | HIS79 | |
| NA | GLU129 | |
| NA | CYS134 | |
| C | CYS141 | |
| NA | CYS141 | |
| PA | HIS79 | |
| PA | GLU129 | |
| PA | CYS134 | |
| PA | CYS141 | |
| RA | HIS79 | |
| RA | GLU129 | |
| RA | CYS134 | |
| RA | CYS141 | |
| TA | HIS79 | |
| E | HIS79 | |
| TA | GLU129 | |
| TA | CYS134 | |
| TA | CYS141 | |
| VA | HIS79 | |
| VA | GLU129 | |
| VA | CYS134 | |
| VA | CYS141 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | SITE: Involved in the phosphoramide link with 7-methyl-GMP => ECO:0000250|UniProtKB:P27282 |
| Chain | Residue | Details |
| A | HIS37 | |
| S | HIS37 | |
| V | HIS37 | |
| X | HIS37 | |
| Z | HIS37 | |
| BA | HIS37 | |
| DA | HIS37 | |
| FA | HIS37 | |
| HA | HIS37 | |
| JA | HIS37 | |
| LA | HIS37 | |
| C | HIS37 | |
| NA | HIS37 | |
| PA | HIS37 | |
| RA | HIS37 | |
| TA | HIS37 | |
| VA | HIS37 | |
| E | HIS37 | |
| G | HIS37 | |
| I | HIS37 | |
| K | HIS37 | |
| M | HIS37 | |
| O | HIS37 | |
| Q | HIS37 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 48 |
| Details | LIPID: S-palmitoyl cysteine; by host => ECO:0000305|PubMed:30404808 |
| Chain | Residue | Details |
| A | CYS417 | |
| I | CYS419 | |
| K | CYS417 | |
| K | CYS419 | |
| M | CYS417 | |
| M | CYS419 | |
| O | CYS417 | |
| O | CYS419 | |
| Q | CYS417 | |
| Q | CYS419 | |
| S | CYS417 | |
| A | CYS419 | |
| S | CYS419 | |
| V | CYS417 | |
| V | CYS419 | |
| X | CYS417 | |
| X | CYS419 | |
| Z | CYS417 | |
| Z | CYS419 | |
| BA | CYS417 | |
| BA | CYS419 | |
| DA | CYS417 | |
| C | CYS417 | |
| DA | CYS419 | |
| FA | CYS417 | |
| FA | CYS419 | |
| HA | CYS417 | |
| HA | CYS419 | |
| JA | CYS417 | |
| JA | CYS419 | |
| LA | CYS417 | |
| LA | CYS419 | |
| NA | CYS417 | |
| C | CYS419 | |
| NA | CYS419 | |
| PA | CYS417 | |
| PA | CYS419 | |
| RA | CYS417 | |
| RA | CYS419 | |
| TA | CYS417 | |
| TA | CYS419 | |
| VA | CYS417 | |
| VA | CYS419 | |
| E | CYS417 | |
| E | CYS419 | |
| G | CYS417 | |
| G | CYS419 | |
| I | CYS417 |
