Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6Z0U

CryoEM structure of the Chikungunya virus nsP1 complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0006396	biological_process	RNA processing
A	0008174	molecular_function	mRNA methyltransferase activity
A	0016556	biological_process	mRNA modification
BA	0003723	molecular_function	RNA binding
BA	0006396	biological_process	RNA processing
BA	0008174	molecular_function	mRNA methyltransferase activity
BA	0016556	biological_process	mRNA modification
C	0003723	molecular_function	RNA binding
C	0006396	biological_process	RNA processing
C	0008174	molecular_function	mRNA methyltransferase activity
C	0016556	biological_process	mRNA modification
DA	0003723	molecular_function	RNA binding
DA	0006396	biological_process	RNA processing
DA	0008174	molecular_function	mRNA methyltransferase activity
DA	0016556	biological_process	mRNA modification
E	0003723	molecular_function	RNA binding
E	0006396	biological_process	RNA processing
E	0008174	molecular_function	mRNA methyltransferase activity
E	0016556	biological_process	mRNA modification
FA	0003723	molecular_function	RNA binding
FA	0006396	biological_process	RNA processing
FA	0008174	molecular_function	mRNA methyltransferase activity
FA	0016556	biological_process	mRNA modification
G	0003723	molecular_function	RNA binding
G	0006396	biological_process	RNA processing
G	0008174	molecular_function	mRNA methyltransferase activity
G	0016556	biological_process	mRNA modification
HA	0003723	molecular_function	RNA binding
HA	0006396	biological_process	RNA processing
HA	0008174	molecular_function	mRNA methyltransferase activity
HA	0016556	biological_process	mRNA modification
I	0003723	molecular_function	RNA binding
I	0006396	biological_process	RNA processing
I	0008174	molecular_function	mRNA methyltransferase activity
I	0016556	biological_process	mRNA modification
JA	0003723	molecular_function	RNA binding
JA	0006396	biological_process	RNA processing
JA	0008174	molecular_function	mRNA methyltransferase activity
JA	0016556	biological_process	mRNA modification
K	0003723	molecular_function	RNA binding
K	0006396	biological_process	RNA processing
K	0008174	molecular_function	mRNA methyltransferase activity
K	0016556	biological_process	mRNA modification
LA	0003723	molecular_function	RNA binding
LA	0006396	biological_process	RNA processing
LA	0008174	molecular_function	mRNA methyltransferase activity
LA	0016556	biological_process	mRNA modification
M	0003723	molecular_function	RNA binding
M	0006396	biological_process	RNA processing
M	0008174	molecular_function	mRNA methyltransferase activity
M	0016556	biological_process	mRNA modification
NA	0003723	molecular_function	RNA binding
NA	0006396	biological_process	RNA processing
NA	0008174	molecular_function	mRNA methyltransferase activity
NA	0016556	biological_process	mRNA modification
O	0003723	molecular_function	RNA binding
O	0006396	biological_process	RNA processing
O	0008174	molecular_function	mRNA methyltransferase activity
O	0016556	biological_process	mRNA modification
PA	0003723	molecular_function	RNA binding
PA	0006396	biological_process	RNA processing
PA	0008174	molecular_function	mRNA methyltransferase activity
PA	0016556	biological_process	mRNA modification
Q	0003723	molecular_function	RNA binding
Q	0006396	biological_process	RNA processing
Q	0008174	molecular_function	mRNA methyltransferase activity
Q	0016556	biological_process	mRNA modification
RA	0003723	molecular_function	RNA binding
RA	0006396	biological_process	RNA processing
RA	0008174	molecular_function	mRNA methyltransferase activity
RA	0016556	biological_process	mRNA modification
S	0003723	molecular_function	RNA binding
S	0006396	biological_process	RNA processing
S	0008174	molecular_function	mRNA methyltransferase activity
S	0016556	biological_process	mRNA modification
TA	0003723	molecular_function	RNA binding
TA	0006396	biological_process	RNA processing
TA	0008174	molecular_function	mRNA methyltransferase activity
TA	0016556	biological_process	mRNA modification
V	0003723	molecular_function	RNA binding
V	0006396	biological_process	RNA processing
V	0008174	molecular_function	mRNA methyltransferase activity
V	0016556	biological_process	mRNA modification
VA	0003723	molecular_function	RNA binding
VA	0006396	biological_process	RNA processing
VA	0008174	molecular_function	mRNA methyltransferase activity
VA	0016556	biological_process	mRNA modification
X	0003723	molecular_function	RNA binding
X	0006396	biological_process	RNA processing
X	0008174	molecular_function	mRNA methyltransferase activity
X	0016556	biological_process	mRNA modification
Z	0003723	molecular_function	RNA binding
Z	0006396	biological_process	RNA processing
Z	0008174	molecular_function	mRNA methyltransferase activity
Z	0016556	biological_process	mRNA modification

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1001

Chain	Residue
A	HIS79
A	GLU129
A	CYS134
A	CYS141

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN C 1001

Chain	Residue
C	HIS79
C	GLU129
C	CYS134
C	CYS141

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN E 1001

Chain	Residue
E	GLU129
E	CYS134
E	CYS141
E	HIS79

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN G 1001

Chain	Residue
G	HIS79
G	GLU129
G	CYS134
G	CYS141

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN I 1001

Chain	Residue
I	HIS79
I	GLU129
I	CYS134
I	CYS141

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN K 1001

Chain	Residue
K	HIS79
K	GLU129
K	CYS134
K	CYS141

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN M 1001

Chain	Residue
M	HIS79
M	GLU129
M	CYS134
M	CYS141

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN O 1001

Chain	Residue
O	HIS79
O	GLU129
O	CYS134
O	CYS141

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN Q 1001

Chain	Residue
Q	HIS79
Q	GLU129
Q	CYS134
Q	CYS141

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN S 1001

Chain	Residue
S	HIS79
S	GLU129
S	CYS134
S	CYS141

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN V 1001

Chain	Residue
V	HIS79
V	GLU129
V	CYS134
V	CYS141

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN X 1001

Chain	Residue
X	HIS79
X	GLU129
X	CYS134
X	CYS141

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN Z 1001

Chain	Residue
Z	HIS79
Z	GLU129
Z	CYS134
Z	CYS141

site_id	AD5
Number of Residues	4
Details	binding site for residue ZN BA 1001

Chain	Residue
BA	HIS79
BA	GLU129
BA	CYS134
BA	CYS141

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN DA 1001

Chain	Residue
DA	HIS79
DA	GLU129
DA	CYS134
DA	CYS141

site_id	AD7
Number of Residues	4
Details	binding site for residue ZN FA 1001

Chain	Residue
FA	HIS79
FA	GLU129
FA	CYS134
FA	CYS141

site_id	AD8
Number of Residues	4
Details	binding site for residue ZN HA 1001

Chain	Residue
HA	HIS79
HA	GLU129
HA	CYS134
HA	CYS141

site_id	AD9
Number of Residues	4
Details	binding site for residue ZN JA 1001

Chain	Residue
JA	HIS79
JA	GLU129
JA	CYS134
JA	CYS141

site_id	AE1
Number of Residues	4
Details	binding site for residue ZN LA 1001

Chain	Residue
LA	HIS79
LA	GLU129
LA	CYS134
LA	CYS141

site_id	AE2
Number of Residues	4
Details	binding site for residue ZN NA 1001

Chain	Residue
NA	HIS79
NA	GLU129
NA	CYS134
NA	CYS141

site_id	AE3
Number of Residues	4
Details	binding site for residue ZN PA 1001

Chain	Residue
PA	HIS79
PA	GLU129
PA	CYS134
PA	CYS141

site_id	AE4
Number of Residues	4
Details	binding site for residue ZN RA 1001

Chain	Residue
RA	HIS79
RA	GLU129
RA	CYS134
RA	CYS141

site_id	AE5
Number of Residues	4
Details	binding site for residue ZN TA 1001

Chain	Residue
TA	HIS79
TA	GLU129
TA	CYS134
TA	CYS141

site_id	AE6
Number of Residues	4
Details	binding site for residue ZN VA 1001

Chain	Residue
VA	HIS79
VA	GLU129
VA	CYS134
VA	CYS141

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5544
Details	Domain: {"description":"Alphavirus-like MT","evidences":[{"source":"PROSITE-ProRule","id":"PRU01079","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Active site: {"description":"For mRNA-capping enzyme nsP1 activity","evidences":[{"source":"PubMed","id":"33730549","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	96
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33730549","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	24
Details	Site: {"description":"Involved in the phosphoramide link with 7-methyl-GMP","evidences":[{"source":"UniProtKB","id":"P27282","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	48
Details	Lipidation: {"description":"S-palmitoyl cysteine; by host","evidences":[{"source":"PubMed","id":"30404808","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)