6YYK
Crystal Structure of 1,5-dimethylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 201 |
Chain | Residue |
A | HIS143 |
A | CYS154 |
A | CYS155 |
A | CYS165 |
site_id | AC2 |
Number of Residues | 1 |
Details | binding site for residue MG A 202 |
Chain | Residue |
B | GLU96 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue ZN B 201 |
Chain | Residue |
B | HIS143 |
B | CYS154 |
B | CYS155 |
B | CYS165 |
site_id | AC4 |
Number of Residues | 2 |
Details | binding site for residue MG B 202 |
Chain | Residue |
A | GLU96 |
B | GLU7 |
site_id | AC5 |
Number of Residues | 9 |
Details | binding site for Di-peptide IS7 B 203 and LYS B 12 |
Chain | Residue |
B | LEU11 |
B | ARG13 |
B | SER14 |
B | GLN15 |
B | PHE25 |
B | LYS26 |
B | TYR39 |
B | LEU111 |
B | TYR112 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10196129 |
Chain | Residue | Details |
A | LYS26 | |
A | CYS28 | |
A | TYR39 | |
A | LYS53 | |
B | LYS26 | |
B | CYS28 | |
B | TYR39 | |
B | LYS53 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00432, ECO:0000269|PubMed:10196129, ECO:0000269|PubMed:9218782, ECO:0000269|Ref.48 |
Chain | Residue | Details |
A | HIS143 | |
A | CYS154 | |
A | CYS155 | |
A | CYS165 | |
B | HIS143 | |
B | CYS154 | |
B | CYS155 | |
B | CYS165 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.11, ECO:0007744|PubMed:25944712 |
Chain | Residue | Details |
A | ALA2 | |
B | ALA2 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:16644721 |
Chain | Residue | Details |
A | SER21 | |
A | SER115 | |
B | SER21 | |
B | SER115 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P35991 |
Chain | Residue | Details |
A | TYR40 | |
B | TYR40 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195 |
Chain | Residue | Details |
A | SER55 | |
B | SER55 |