6YXU

Structure of Mycobacterium smegmatis HelD protein in complex with RNA polymerase core - State I, primary channel engaged

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0005737	cellular_component	cytoplasm
A	0006351	biological_process	DNA-templated transcription
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0046983	molecular_function	protein dimerization activity
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0005737	cellular_component	cytoplasm
B	0006351	biological_process	DNA-templated transcription
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046983	molecular_function	protein dimerization activity
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0005515	molecular_function	protein binding
C	0006351	biological_process	DNA-templated transcription
C	0032549	molecular_function	ribonucleoside binding
C	0034062	molecular_function	5'-3' RNA polymerase activity
D	0000287	molecular_function	magnesium ion binding
D	0003677	molecular_function	DNA binding
D	0003899	molecular_function	DNA-directed RNA polymerase activity
D	0006351	biological_process	DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
D	0034062	molecular_function	5'-3' RNA polymerase activity
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0006351	biological_process	DNA-templated transcription
E	0034062	molecular_function	5'-3' RNA polymerase activity
H	0000725	biological_process	recombinational repair
H	0003677	molecular_function	DNA binding
H	0003678	molecular_function	DNA helicase activity
H	0003711	molecular_function	transcription elongation factor activity
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0043138	molecular_function	3'-5' DNA helicase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN D 2001

Chain	Residue
D	CYS890
D	ARG962
D	CYS967
D	CYS974
D	CYS977

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN D 2002

Chain	Residue
D	CYS60
D	CYS62
D	CYS75
D	CYS78

---

site_id	AC3
Number of Residues	3
Details	binding site for residue MG D 2003

Chain	Residue
D	ASP535
D	ASP537
D	ASP539

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	450
Details	Region: {"description":"Alpha N-terminal domain (alpha-NTD)","evidences":[{"source":"HAMAP-Rule","id":"MF_00059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"6YXU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6YYS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Z11","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	56
Details	Coiled coil: {"evidences":[{"source":"PubMed","id":"33339823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6YXU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6YYS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Z11","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00560","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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