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6YW7

Cryo-EM structure of the ARP2/3 1A5C isoform complex.

Functional Information from GO Data
ChainGOidnamespacecontents
A0003779molecular_functionactin binding
A0005200molecular_functionstructural constituent of cytoskeleton
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005885cellular_componentArp2/3 protein complex
A0005903cellular_componentbrush border
A0005911cellular_componentcell-cell junction
A0005925cellular_componentfocal adhesion
A0007163biological_processestablishment or maintenance of cell polarity
A0008356biological_processasymmetric cell division
A0010592biological_processpositive regulation of lamellipodium assembly
A0015629cellular_componentactin cytoskeleton
A0016020cellular_componentmembrane
A0016344biological_processmeiotic chromosome movement towards spindle pole
A0030027cellular_componentlamellipodium
A0030030biological_processcell projection organization
A0033206biological_processmeiotic cytokinesis
A0034314biological_processArp2/3 complex-mediated actin nucleation
A0035861cellular_componentsite of double-strand break
A0042995cellular_componentcell projection
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0051015molecular_functionactin filament binding
A0051321biological_processmeiotic cell cycle
A0051653biological_processspindle localization
A0060271biological_processcilium assembly
A0070062cellular_componentextracellular exosome
A0070358biological_processactin polymerization-dependent cell motility
A0071346biological_processcellular response to type II interferon
B0003779molecular_functionactin binding
B0005200molecular_functionstructural constituent of cytoskeleton
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005885cellular_componentArp2/3 protein complex
B0005925cellular_componentfocal adhesion
B0005938cellular_componentcell cortex
B0007163biological_processestablishment or maintenance of cell polarity
B0008356biological_processasymmetric cell division
B0010592biological_processpositive regulation of lamellipodium assembly
B0015629cellular_componentactin cytoskeleton
B0016020cellular_componentmembrane
B0016344biological_processmeiotic chromosome movement towards spindle pole
B0016482biological_processcytosolic transport
B0030036biological_processactin cytoskeleton organization
B0030478cellular_componentactin cap
B0033206biological_processmeiotic cytokinesis
B0034314biological_processArp2/3 complex-mediated actin nucleation
B0035578cellular_componentazurophil granule lumen
B0035861cellular_componentsite of double-strand break
B0042995cellular_componentcell projection
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0051015molecular_functionactin filament binding
B0051321biological_processmeiotic cell cycle
B0051653biological_processspindle localization
B0060271biological_processcilium assembly
B0070062cellular_componentextracellular exosome
B0071346biological_processcellular response to type II interferon
B1904813cellular_componentficolin-1-rich granule lumen
B1905168biological_processpositive regulation of double-strand break repair via homologous recombination
B2001032biological_processregulation of double-strand break repair via nonhomologous end joining
C0003779molecular_functionactin binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005885cellular_componentArp2/3 protein complex
C0015629cellular_componentactin cytoskeleton
C0030036biological_processactin cytoskeleton organization
C0034314biological_processArp2/3 complex-mediated actin nucleation
C0035861cellular_componentsite of double-strand break
C0036195cellular_componentmuscle cell projection membrane
C0045202cellular_componentsynapse
C0051015molecular_functionactin filament binding
C0070062cellular_componentextracellular exosome
C0098978cellular_componentglutamatergic synapse
D0003779molecular_functionactin binding
D0005200molecular_functionstructural constituent of cytoskeleton
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005768cellular_componentendosome
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005885cellular_componentArp2/3 protein complex
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0010592biological_processpositive regulation of lamellipodium assembly
D0015629cellular_componentactin cytoskeleton
D0030027cellular_componentlamellipodium
D0030041biological_processactin filament polymerization
D0030672cellular_componentsynaptic vesicle membrane
D0030838biological_processpositive regulation of actin filament polymerization
D0031252cellular_componentcell leading edge
D0034314biological_processArp2/3 complex-mediated actin nucleation
D0035861cellular_componentsite of double-strand break
D0036195cellular_componentmuscle cell projection membrane
D0042995cellular_componentcell projection
D0043005cellular_componentneuron projection
D0045202cellular_componentsynapse
D0051015molecular_functionactin filament binding
D0070062cellular_componentextracellular exosome
D0070358biological_processactin polymerization-dependent cell motility
D0098793cellular_componentpresynapse
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
E0003779molecular_functionactin binding
E0005200molecular_functionstructural constituent of cytoskeleton
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005885cellular_componentArp2/3 protein complex
E0005925cellular_componentfocal adhesion
E0015629cellular_componentactin cytoskeleton
E0016020cellular_componentmembrane
E0030027cellular_componentlamellipodium
E0030833biological_processregulation of actin filament polymerization
E0031252cellular_componentcell leading edge
E0031941cellular_componentfilamentous actin
E0034314biological_processArp2/3 complex-mediated actin nucleation
E0035861cellular_componentsite of double-strand break
E0042995cellular_componentcell projection
E0051015molecular_functionactin filament binding
E0061850cellular_componentgrowth cone leading edge
E0070062cellular_componentextracellular exosome
E0070358biological_processactin polymerization-dependent cell motility
E1900242biological_processregulation of synaptic vesicle endocytosis
E1990090biological_processcellular response to nerve growth factor stimulus
F0003779molecular_functionactin binding
F0005200molecular_functionstructural constituent of cytoskeleton
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005885cellular_componentArp2/3 protein complex
F0015629cellular_componentactin cytoskeleton
F0019899molecular_functionenzyme binding
F0030041biological_processactin filament polymerization
F0030674molecular_functionprotein-macromolecule adaptor activity
F0034314biological_processArp2/3 complex-mediated actin nucleation
F0035861cellular_componentsite of double-strand break
F0042995cellular_componentcell projection
F0045010biological_processactin nucleation
F0051015molecular_functionactin filament binding
F0070062cellular_componentextracellular exosome
G0003779molecular_functionactin binding
G0005200molecular_functionstructural constituent of cytoskeleton
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0005885cellular_componentArp2/3 protein complex
G0005925cellular_componentfocal adhesion
G0015629cellular_componentactin cytoskeleton
G0016477biological_processcell migration
G0030027cellular_componentlamellipodium
G0030036biological_processactin cytoskeleton organization
G0030833biological_processregulation of actin filament polymerization
G0034314biological_processArp2/3 complex-mediated actin nucleation
G0034774cellular_componentsecretory granule lumen
G0035861cellular_componentsite of double-strand break
G0042995cellular_componentcell projection
G0051015molecular_functionactin filament binding
G0070062cellular_componentextracellular exosome
G1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue ATP A 501
ChainResidue
AGLY13
ATHR14
AGLY15
ATYR16
AGLY171
AASP172
AGLY323
AGLY324
ASER325

site_idAC2
Number of Residues10
Detailsbinding site for residue ATP B 401
ChainResidue
BGLY14
BTHR15
BGLY16
BPHE17
BGLY160
BASP161
BGLY306
BSER307
BMET309
BTYR310

Functional Information from PROSITE/UniProt
site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEPpMNPtkNR
ChainResidueDetails
BLEU108-ARG120
ALEU111-ARG123

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylserine => ECO:0007744|PubMed:22814378
ChainResidueDetails
GSER2
BARG214
BGLY305

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:25944712
ChainResidueDetails
BMET1
ELYS61
ALYS251
ALYS254

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS299
BLYS322

225946

PDB entries from 2024-10-09

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