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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6YTV

Cryo-EM structure of decameric human CALHM6 in the presence of Ca2+

Functional Information from GO Data
ChainGOidnamespacecontents
A0001772cellular_componentimmunological synapse
A0002727biological_processregulation of natural killer cell cytokine production
A0005261molecular_functionmonoatomic cation channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0022832molecular_functionvoltage-gated channel activity
A0034220biological_processmonoatomic ion transmembrane transport
A0098655biological_processmonoatomic cation transmembrane transport
A1904669biological_processATP export
B0001772cellular_componentimmunological synapse
B0002727biological_processregulation of natural killer cell cytokine production
B0005261molecular_functionmonoatomic cation channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0022832molecular_functionvoltage-gated channel activity
B0034220biological_processmonoatomic ion transmembrane transport
B0098655biological_processmonoatomic cation transmembrane transport
B1904669biological_processATP export
C0001772cellular_componentimmunological synapse
C0002727biological_processregulation of natural killer cell cytokine production
C0005261molecular_functionmonoatomic cation channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0022832molecular_functionvoltage-gated channel activity
C0034220biological_processmonoatomic ion transmembrane transport
C0098655biological_processmonoatomic cation transmembrane transport
C1904669biological_processATP export
D0001772cellular_componentimmunological synapse
D0002727biological_processregulation of natural killer cell cytokine production
D0005261molecular_functionmonoatomic cation channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0022832molecular_functionvoltage-gated channel activity
D0034220biological_processmonoatomic ion transmembrane transport
D0098655biological_processmonoatomic cation transmembrane transport
D1904669biological_processATP export
E0001772cellular_componentimmunological synapse
E0002727biological_processregulation of natural killer cell cytokine production
E0005261molecular_functionmonoatomic cation channel activity
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0022832molecular_functionvoltage-gated channel activity
E0034220biological_processmonoatomic ion transmembrane transport
E0098655biological_processmonoatomic cation transmembrane transport
E1904669biological_processATP export
F0001772cellular_componentimmunological synapse
F0002727biological_processregulation of natural killer cell cytokine production
F0005261molecular_functionmonoatomic cation channel activity
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0006811biological_processmonoatomic ion transport
F0022832molecular_functionvoltage-gated channel activity
F0034220biological_processmonoatomic ion transmembrane transport
F0098655biological_processmonoatomic cation transmembrane transport
F1904669biological_processATP export
G0001772cellular_componentimmunological synapse
G0002727biological_processregulation of natural killer cell cytokine production
G0005261molecular_functionmonoatomic cation channel activity
G0005515molecular_functionprotein binding
G0005886cellular_componentplasma membrane
G0006811biological_processmonoatomic ion transport
G0022832molecular_functionvoltage-gated channel activity
G0034220biological_processmonoatomic ion transmembrane transport
G0098655biological_processmonoatomic cation transmembrane transport
G1904669biological_processATP export
H0001772cellular_componentimmunological synapse
H0002727biological_processregulation of natural killer cell cytokine production
H0005261molecular_functionmonoatomic cation channel activity
H0005515molecular_functionprotein binding
H0005886cellular_componentplasma membrane
H0006811biological_processmonoatomic ion transport
H0022832molecular_functionvoltage-gated channel activity
H0034220biological_processmonoatomic ion transmembrane transport
H0098655biological_processmonoatomic cation transmembrane transport
H1904669biological_processATP export
I0001772cellular_componentimmunological synapse
I0002727biological_processregulation of natural killer cell cytokine production
I0005261molecular_functionmonoatomic cation channel activity
I0005515molecular_functionprotein binding
I0005886cellular_componentplasma membrane
I0006811biological_processmonoatomic ion transport
I0022832molecular_functionvoltage-gated channel activity
I0034220biological_processmonoatomic ion transmembrane transport
I0098655biological_processmonoatomic cation transmembrane transport
I1904669biological_processATP export
J0001772cellular_componentimmunological synapse
J0002727biological_processregulation of natural killer cell cytokine production
J0005261molecular_functionmonoatomic cation channel activity
J0005515molecular_functionprotein binding
J0005886cellular_componentplasma membrane
J0006811biological_processmonoatomic ion transport
J0022832molecular_functionvoltage-gated channel activity
J0034220biological_processmonoatomic ion transmembrane transport
J0098655biological_processmonoatomic cation transmembrane transport
J1904669biological_processATP export
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues150
DetailsTransmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"32374262","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6YTV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues490
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues210
DetailsTransmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"32374262","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6YTV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues240
DetailsTransmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"32374262","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6YTV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues220
DetailsTransmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"32374262","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6YTV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2026-01-14

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