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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6YTQ

Cryo-EM structure of a dimer of undecameric human CALHM4 in the presence of Ca2+

Functional Information from GO Data
ChainGOidnamespacecontents
A0005261molecular_functionmonoatomic cation channel activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0016020cellular_componentmembrane
A0034220biological_processmonoatomic ion transmembrane transport
A0098655biological_processmonoatomic cation transmembrane transport
A1904669biological_processATP export
B0005261molecular_functionmonoatomic cation channel activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0016020cellular_componentmembrane
B0034220biological_processmonoatomic ion transmembrane transport
B0098655biological_processmonoatomic cation transmembrane transport
B1904669biological_processATP export
C0005261molecular_functionmonoatomic cation channel activity
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0016020cellular_componentmembrane
C0034220biological_processmonoatomic ion transmembrane transport
C0098655biological_processmonoatomic cation transmembrane transport
C1904669biological_processATP export
D0005261molecular_functionmonoatomic cation channel activity
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0016020cellular_componentmembrane
D0034220biological_processmonoatomic ion transmembrane transport
D0098655biological_processmonoatomic cation transmembrane transport
D1904669biological_processATP export
E0005261molecular_functionmonoatomic cation channel activity
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0016020cellular_componentmembrane
E0034220biological_processmonoatomic ion transmembrane transport
E0098655biological_processmonoatomic cation transmembrane transport
E1904669biological_processATP export
F0005261molecular_functionmonoatomic cation channel activity
F0005886cellular_componentplasma membrane
F0006811biological_processmonoatomic ion transport
F0016020cellular_componentmembrane
F0034220biological_processmonoatomic ion transmembrane transport
F0098655biological_processmonoatomic cation transmembrane transport
F1904669biological_processATP export
G0005261molecular_functionmonoatomic cation channel activity
G0005886cellular_componentplasma membrane
G0006811biological_processmonoatomic ion transport
G0016020cellular_componentmembrane
G0034220biological_processmonoatomic ion transmembrane transport
G0098655biological_processmonoatomic cation transmembrane transport
G1904669biological_processATP export
H0005261molecular_functionmonoatomic cation channel activity
H0005886cellular_componentplasma membrane
H0006811biological_processmonoatomic ion transport
H0016020cellular_componentmembrane
H0034220biological_processmonoatomic ion transmembrane transport
H0098655biological_processmonoatomic cation transmembrane transport
H1904669biological_processATP export
I0005261molecular_functionmonoatomic cation channel activity
I0005886cellular_componentplasma membrane
I0006811biological_processmonoatomic ion transport
I0016020cellular_componentmembrane
I0034220biological_processmonoatomic ion transmembrane transport
I0098655biological_processmonoatomic cation transmembrane transport
I1904669biological_processATP export
J0005261molecular_functionmonoatomic cation channel activity
J0005886cellular_componentplasma membrane
J0006811biological_processmonoatomic ion transport
J0016020cellular_componentmembrane
J0034220biological_processmonoatomic ion transmembrane transport
J0098655biological_processmonoatomic cation transmembrane transport
J1904669biological_processATP export
K0005261molecular_functionmonoatomic cation channel activity
K0005886cellular_componentplasma membrane
K0006811biological_processmonoatomic ion transport
K0016020cellular_componentmembrane
K0034220biological_processmonoatomic ion transmembrane transport
K0098655biological_processmonoatomic cation transmembrane transport
K1904669biological_processATP export
L0005261molecular_functionmonoatomic cation channel activity
L0005886cellular_componentplasma membrane
L0006811biological_processmonoatomic ion transport
L0016020cellular_componentmembrane
L0034220biological_processmonoatomic ion transmembrane transport
L0098655biological_processmonoatomic cation transmembrane transport
L1904669biological_processATP export
M0005261molecular_functionmonoatomic cation channel activity
M0005886cellular_componentplasma membrane
M0006811biological_processmonoatomic ion transport
M0016020cellular_componentmembrane
M0034220biological_processmonoatomic ion transmembrane transport
M0098655biological_processmonoatomic cation transmembrane transport
M1904669biological_processATP export
N0005261molecular_functionmonoatomic cation channel activity
N0005886cellular_componentplasma membrane
N0006811biological_processmonoatomic ion transport
N0016020cellular_componentmembrane
N0034220biological_processmonoatomic ion transmembrane transport
N0098655biological_processmonoatomic cation transmembrane transport
N1904669biological_processATP export
O0005261molecular_functionmonoatomic cation channel activity
O0005886cellular_componentplasma membrane
O0006811biological_processmonoatomic ion transport
O0016020cellular_componentmembrane
O0034220biological_processmonoatomic ion transmembrane transport
O0098655biological_processmonoatomic cation transmembrane transport
O1904669biological_processATP export
P0005261molecular_functionmonoatomic cation channel activity
P0005886cellular_componentplasma membrane
P0006811biological_processmonoatomic ion transport
P0016020cellular_componentmembrane
P0034220biological_processmonoatomic ion transmembrane transport
P0098655biological_processmonoatomic cation transmembrane transport
P1904669biological_processATP export
Q0005261molecular_functionmonoatomic cation channel activity
Q0005886cellular_componentplasma membrane
Q0006811biological_processmonoatomic ion transport
Q0016020cellular_componentmembrane
Q0034220biological_processmonoatomic ion transmembrane transport
Q0098655biological_processmonoatomic cation transmembrane transport
Q1904669biological_processATP export
R0005261molecular_functionmonoatomic cation channel activity
R0005886cellular_componentplasma membrane
R0006811biological_processmonoatomic ion transport
R0016020cellular_componentmembrane
R0034220biological_processmonoatomic ion transmembrane transport
R0098655biological_processmonoatomic cation transmembrane transport
R1904669biological_processATP export
S0005261molecular_functionmonoatomic cation channel activity
S0005886cellular_componentplasma membrane
S0006811biological_processmonoatomic ion transport
S0016020cellular_componentmembrane
S0034220biological_processmonoatomic ion transmembrane transport
S0098655biological_processmonoatomic cation transmembrane transport
S1904669biological_processATP export
T0005261molecular_functionmonoatomic cation channel activity
T0005886cellular_componentplasma membrane
T0006811biological_processmonoatomic ion transport
T0016020cellular_componentmembrane
T0034220biological_processmonoatomic ion transmembrane transport
T0098655biological_processmonoatomic cation transmembrane transport
T1904669biological_processATP export
U0005261molecular_functionmonoatomic cation channel activity
U0005886cellular_componentplasma membrane
U0006811biological_processmonoatomic ion transport
U0016020cellular_componentmembrane
U0034220biological_processmonoatomic ion transmembrane transport
U0098655biological_processmonoatomic cation transmembrane transport
U1904669biological_processATP export
V0005261molecular_functionmonoatomic cation channel activity
V0005886cellular_componentplasma membrane
V0006811biological_processmonoatomic ion transport
V0016020cellular_componentmembrane
V0034220biological_processmonoatomic ion transmembrane transport
V0098655biological_processmonoatomic cation transmembrane transport
V1904669biological_processATP export
Functional Information from PROSITE/UniProt
site_idPS01186
Number of Residues15
DetailsEGF_2 EGF-like domain signature 2. CsCapPYrrisple.C
ChainResidueDetails
ACYS83-CYS97
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues484
DetailsTransmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"32374262","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6YTK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1386
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues484
DetailsTransmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"32374262","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6YTK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues550
DetailsTransmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"32374262","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6YTK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues506
DetailsTransmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"32374262","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6YTK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

240971

PDB entries from 2025-08-27

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