6YTQ

Cryo-EM structure of a dimer of undecameric human CALHM4 in the presence of Ca2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005261	molecular_function	monoatomic cation channel activity
A	0005886	cellular_component	plasma membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0098655	biological_process	monoatomic cation transmembrane transport
B	0005261	molecular_function	monoatomic cation channel activity
B	0005886	cellular_component	plasma membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0098655	biological_process	monoatomic cation transmembrane transport
C	0005261	molecular_function	monoatomic cation channel activity
C	0005886	cellular_component	plasma membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0098655	biological_process	monoatomic cation transmembrane transport
D	0005261	molecular_function	monoatomic cation channel activity
D	0005886	cellular_component	plasma membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0098655	biological_process	monoatomic cation transmembrane transport
E	0005261	molecular_function	monoatomic cation channel activity
E	0005886	cellular_component	plasma membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0098655	biological_process	monoatomic cation transmembrane transport
F	0005261	molecular_function	monoatomic cation channel activity
F	0005886	cellular_component	plasma membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0098655	biological_process	monoatomic cation transmembrane transport
G	0005261	molecular_function	monoatomic cation channel activity
G	0005886	cellular_component	plasma membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0098655	biological_process	monoatomic cation transmembrane transport
H	0005261	molecular_function	monoatomic cation channel activity
H	0005886	cellular_component	plasma membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
H	0098655	biological_process	monoatomic cation transmembrane transport
I	0005261	molecular_function	monoatomic cation channel activity
I	0005886	cellular_component	plasma membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
I	0098655	biological_process	monoatomic cation transmembrane transport
J	0005261	molecular_function	monoatomic cation channel activity
J	0005886	cellular_component	plasma membrane
J	0034220	biological_process	monoatomic ion transmembrane transport
J	0098655	biological_process	monoatomic cation transmembrane transport
K	0005261	molecular_function	monoatomic cation channel activity
K	0005886	cellular_component	plasma membrane
K	0034220	biological_process	monoatomic ion transmembrane transport
K	0098655	biological_process	monoatomic cation transmembrane transport
L	0005261	molecular_function	monoatomic cation channel activity
L	0005886	cellular_component	plasma membrane
L	0034220	biological_process	monoatomic ion transmembrane transport
L	0098655	biological_process	monoatomic cation transmembrane transport
M	0005261	molecular_function	monoatomic cation channel activity
M	0005886	cellular_component	plasma membrane
M	0034220	biological_process	monoatomic ion transmembrane transport
M	0098655	biological_process	monoatomic cation transmembrane transport
N	0005261	molecular_function	monoatomic cation channel activity
N	0005886	cellular_component	plasma membrane
N	0034220	biological_process	monoatomic ion transmembrane transport
N	0098655	biological_process	monoatomic cation transmembrane transport
O	0005261	molecular_function	monoatomic cation channel activity
O	0005886	cellular_component	plasma membrane
O	0034220	biological_process	monoatomic ion transmembrane transport
O	0098655	biological_process	monoatomic cation transmembrane transport
P	0005261	molecular_function	monoatomic cation channel activity
P	0005886	cellular_component	plasma membrane
P	0034220	biological_process	monoatomic ion transmembrane transport
P	0098655	biological_process	monoatomic cation transmembrane transport
Q	0005261	molecular_function	monoatomic cation channel activity
Q	0005886	cellular_component	plasma membrane
Q	0034220	biological_process	monoatomic ion transmembrane transport
Q	0098655	biological_process	monoatomic cation transmembrane transport
R	0005261	molecular_function	monoatomic cation channel activity
R	0005886	cellular_component	plasma membrane
R	0034220	biological_process	monoatomic ion transmembrane transport
R	0098655	biological_process	monoatomic cation transmembrane transport
S	0005261	molecular_function	monoatomic cation channel activity
S	0005886	cellular_component	plasma membrane
S	0034220	biological_process	monoatomic ion transmembrane transport
S	0098655	biological_process	monoatomic cation transmembrane transport
T	0005261	molecular_function	monoatomic cation channel activity
T	0005886	cellular_component	plasma membrane
T	0034220	biological_process	monoatomic ion transmembrane transport
T	0098655	biological_process	monoatomic cation transmembrane transport
U	0005261	molecular_function	monoatomic cation channel activity
U	0005886	cellular_component	plasma membrane
U	0034220	biological_process	monoatomic ion transmembrane transport
U	0098655	biological_process	monoatomic cation transmembrane transport
V	0005261	molecular_function	monoatomic cation channel activity
V	0005886	cellular_component	plasma membrane
V	0034220	biological_process	monoatomic ion transmembrane transport
V	0098655	biological_process	monoatomic cation transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS01186
Number of Residues	15
Details	EGF_2 EGF-like domain signature 2. CsCapPYrrisple.C

Chain	Residue	Details
A	CYS83-CYS97

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3300
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	MET1-ARG14
D	MET1-ARG14
D	SER72-ARG103
D	LYS208-PRO314
E	MET1-ARG14
E	SER72-ARG103
E	LYS208-PRO314
F	MET1-ARG14
F	SER72-ARG103
F	LYS208-PRO314
G	MET1-ARG14
A	SER72-ARG103
G	SER72-ARG103
G	LYS208-PRO314
H	MET1-ARG14
H	SER72-ARG103
H	LYS208-PRO314
I	MET1-ARG14
I	SER72-ARG103
I	LYS208-PRO314
J	MET1-ARG14
J	SER72-ARG103
A	LYS208-PRO314
J	LYS208-PRO314
K	MET1-ARG14
K	SER72-ARG103
K	LYS208-PRO314
L	MET1-ARG14
L	SER72-ARG103
L	LYS208-PRO314
M	MET1-ARG14
M	SER72-ARG103
M	LYS208-PRO314
B	MET1-ARG14
N	MET1-ARG14
N	SER72-ARG103
N	LYS208-PRO314
O	MET1-ARG14
O	SER72-ARG103
O	LYS208-PRO314
P	MET1-ARG14
P	SER72-ARG103
P	LYS208-PRO314
Q	MET1-ARG14
B	SER72-ARG103
Q	SER72-ARG103
Q	LYS208-PRO314
R	MET1-ARG14
R	SER72-ARG103
R	LYS208-PRO314
S	MET1-ARG14
S	SER72-ARG103
S	LYS208-PRO314
T	MET1-ARG14
T	SER72-ARG103
B	LYS208-PRO314
T	LYS208-PRO314
U	MET1-ARG14
U	SER72-ARG103
U	LYS208-PRO314
V	MET1-ARG14
V	SER72-ARG103
V	LYS208-PRO314
C	MET1-ARG14
C	SER72-ARG103
C	LYS208-PRO314

---

site_id	SWS_FT_FI2
Number of Residues	484
Details	TRANSMEM: Helical; Name=S1 => ECO:0000269|PubMed:32374262, ECO:0007744|PDB:6YTK

Chain	Residue	Details
A	ASN15-SER37
J	ASN15-SER37
K	ASN15-SER37
L	ASN15-SER37
M	ASN15-SER37
N	ASN15-SER37
O	ASN15-SER37
P	ASN15-SER37
Q	ASN15-SER37
R	ASN15-SER37
S	ASN15-SER37
B	ASN15-SER37
T	ASN15-SER37
U	ASN15-SER37
V	ASN15-SER37
C	ASN15-SER37
D	ASN15-SER37
E	ASN15-SER37
F	ASN15-SER37
G	ASN15-SER37
H	ASN15-SER37
I	ASN15-SER37

---

site_id	SWS_FT_FI3
Number of Residues	1386
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	THR38-ASN48
E	GLU130-TYR183
F	THR38-ASN48
F	GLU130-TYR183
G	THR38-ASN48
G	GLU130-TYR183
H	THR38-ASN48
H	GLU130-TYR183
I	THR38-ASN48
I	GLU130-TYR183
J	THR38-ASN48
A	GLU130-TYR183
J	GLU130-TYR183
K	THR38-ASN48
K	GLU130-TYR183
L	THR38-ASN48
L	GLU130-TYR183
M	THR38-ASN48
M	GLU130-TYR183
N	THR38-ASN48
N	GLU130-TYR183
O	THR38-ASN48
B	THR38-ASN48
O	GLU130-TYR183
P	THR38-ASN48
P	GLU130-TYR183
Q	THR38-ASN48
Q	GLU130-TYR183
R	THR38-ASN48
R	GLU130-TYR183
S	THR38-ASN48
S	GLU130-TYR183
T	THR38-ASN48
B	GLU130-TYR183
T	GLU130-TYR183
U	THR38-ASN48
U	GLU130-TYR183
V	THR38-ASN48
V	GLU130-TYR183
C	THR38-ASN48
C	GLU130-TYR183
D	THR38-ASN48
D	GLU130-TYR183
E	THR38-ASN48

---

site_id	SWS_FT_FI4
Number of Residues	484
Details	TRANSMEM: Helical; Name=S2 => ECO:0000269|PubMed:32374262, ECO:0007744|PDB:6YTK

Chain	Residue	Details
A	PHE49-ARG71
J	PHE49-ARG71
K	PHE49-ARG71
L	PHE49-ARG71
M	PHE49-ARG71
N	PHE49-ARG71
O	PHE49-ARG71
P	PHE49-ARG71
Q	PHE49-ARG71
R	PHE49-ARG71
S	PHE49-ARG71
B	PHE49-ARG71
T	PHE49-ARG71
U	PHE49-ARG71
V	PHE49-ARG71
C	PHE49-ARG71
D	PHE49-ARG71
E	PHE49-ARG71
F	PHE49-ARG71
G	PHE49-ARG71
H	PHE49-ARG71
I	PHE49-ARG71

---

site_id	SWS_FT_FI5
Number of Residues	550
Details	TRANSMEM: Helical; Name=S3 => ECO:0000269|PubMed:32374262, ECO:0007744|PDB:6YTK

Chain	Residue	Details
A	PHE104-TYR129
J	PHE104-TYR129
K	PHE104-TYR129
L	PHE104-TYR129
M	PHE104-TYR129
N	PHE104-TYR129
O	PHE104-TYR129
P	PHE104-TYR129
Q	PHE104-TYR129
R	PHE104-TYR129
S	PHE104-TYR129
B	PHE104-TYR129
T	PHE104-TYR129
U	PHE104-TYR129
V	PHE104-TYR129
C	PHE104-TYR129
D	PHE104-TYR129
E	PHE104-TYR129
F	PHE104-TYR129
G	PHE104-TYR129
H	PHE104-TYR129
I	PHE104-TYR129

---

site_id	SWS_FT_FI6
Number of Residues	506
Details	TRANSMEM: Helical; Name=S4 => ECO:0000269|PubMed:32374262, ECO:0007744|PDB:6YTK

Chain	Residue	Details
A	GLN184-ALA207
J	GLN184-ALA207
K	GLN184-ALA207
L	GLN184-ALA207
M	GLN184-ALA207
N	GLN184-ALA207
O	GLN184-ALA207
P	GLN184-ALA207
Q	GLN184-ALA207
R	GLN184-ALA207
S	GLN184-ALA207
B	GLN184-ALA207
T	GLN184-ALA207
U	GLN184-ALA207
V	GLN184-ALA207
C	GLN184-ALA207
D	GLN184-ALA207
E	GLN184-ALA207
F	GLN184-ALA207
G	GLN184-ALA207
H	GLN184-ALA207
I	GLN184-ALA207

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