6YSW
E. coli anaerobic trifunctional enzyme subunit-alpha in complex with coenzyme A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003857 | molecular_function | (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity |
| A | 0004300 | molecular_function | enoyl-CoA hydratase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006635 | biological_process | fatty acid beta-oxidation |
| A | 0008692 | molecular_function | 3-hydroxybutyryl-CoA epimerase activity |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016509 | molecular_function | long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0018812 | molecular_function | 3-hydroxyacyl-CoA dehydratase activity |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003857 | molecular_function | (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity |
| B | 0004300 | molecular_function | enoyl-CoA hydratase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006635 | biological_process | fatty acid beta-oxidation |
| B | 0008692 | molecular_function | 3-hydroxybutyryl-CoA epimerase activity |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016509 | molecular_function | long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0018812 | molecular_function | 3-hydroxyacyl-CoA dehydratase activity |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 801 |
| Chain | Residue |
| B | MET454 |
| B | GLY652 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 802 |
| Chain | Residue |
| B | ALA69 |
| B | PRO147 |
| B | GLY148 |
| B | SER149 |
| B | PHE273 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 B 803 |
| Chain | Residue |
| B | TYR244 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 804 |
| Chain | Residue |
| B | ILE159 |
| B | SER162 |
| B | THR163 |
| A | GLU216 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 801 |
| Chain | Residue |
| A | ARG336 |
| A | ARG384 |
| A | ARG384 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 802 |
| Chain | Residue |
| A | LYS338 |
| A | TYR383 |
| A | GLU409 |
| A | ASN413 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 A 803 |
| Chain | Residue |
| A | TYR244 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 804 |
| Chain | Residue |
| A | GLY686 |
| A | SER687 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 805 |
| Chain | Residue |
| A | ALA69 |
| A | MET73 |
| A | LEU86 |
| A | SER149 |
| A | PHE273 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 806 |
| Chain | Residue |
| A | ARG384 |
| A | ARG384 |
| A | GLY385 |
| A | GLY385 |
| A | PHE386 |
| A | PHE386 |
| A | ALA387 |
| A | ALA387 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 807 |
| Chain | Residue |
| A | GLY317 |
| A | LEU318 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 808 |
| Chain | Residue |
| A | ARG157 |
| A | GLY261 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 809 |
| Chain | Residue |
| A | MET454 |
| A | VAL539 |
| site_id | AD5 |
| Number of Residues | 11 |
| Details | binding site for residue COA A 810 |
| Chain | Residue |
| A | GLU26 |
| A | MET28 |
| A | ALA69 |
| A | ASP70 |
| A | ILE71 |
| A | PRO139 |
| A | GLU140 |
| A | LEU143 |
| A | PHE289 |
| A | THR293 |
| A | LYS296 |
Functional Information from PROSITE/UniProt
| site_id | PS00067 |
| Number of Residues | 25 |
| Details | 3HCDH 3-hydroxyacyl-CoA dehydrogenase signature. DkaGFYvNRilaPYIneair.MLtqG |
| Chain | Residue | Details |
| B | ASP489-GLY513 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important for catalytic activity","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
