6YSV

E. coli anaerobic trifunctional enzyme subunit-alpha

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
A	0004300	molecular_function	enoyl-CoA hydratase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006635	biological_process	fatty acid beta-oxidation
A	0008692	molecular_function	3-hydroxybutyryl-CoA epimerase activity
A	0016042	biological_process	lipid catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016509	molecular_function	long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0016829	molecular_function	lyase activity
A	0016853	molecular_function	isomerase activity
A	0018812	molecular_function	3-hydroxyacyl-CoA dehydratase activity
A	0036125	cellular_component	fatty acid beta-oxidation multienzyme complex
A	0051287	molecular_function	NAD binding
A	0070403	molecular_function	NAD+ binding
B	0003824	molecular_function	catalytic activity
B	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
B	0004300	molecular_function	enoyl-CoA hydratase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006635	biological_process	fatty acid beta-oxidation
B	0008692	molecular_function	3-hydroxybutyryl-CoA epimerase activity
B	0016042	biological_process	lipid catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016509	molecular_function	long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0016829	molecular_function	lyase activity
B	0016853	molecular_function	isomerase activity
B	0018812	molecular_function	3-hydroxyacyl-CoA dehydratase activity
B	0036125	cellular_component	fatty acid beta-oxidation multienzyme complex
B	0051287	molecular_function	NAD binding
B	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 A 801

Chain	Residue
A	LYS338
A	TYR383
A	PHE386
A	GLU409
A	ASN413

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site_id	AC2
Number of Residues	2
Details	binding site for residue SO4 A 802

Chain	Residue
A	GLY686
A	SER687

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site_id	AC3
Number of Residues	2
Details	binding site for residue SO4 A 803

Chain	Residue
A	LYS235
A	THR236

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site_id	AC4
Number of Residues	10
Details	binding site for residue SO4 A 804

Chain	Residue
A	TYR383
A	TYR383
A	ARG384
A	ARG384
A	GLY385
A	GLY385
A	PHE386
A	PHE386
A	ALA387
A	ALA387

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site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 A 805

Chain	Residue
A	ARG384
A	ARG384

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site_id	AC6
Number of Residues	3
Details	binding site for residue SO4 B 801

Chain	Residue
A	ARG217
B	GLU166
B	LYS235

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site_id	AC7
Number of Residues	2
Details	binding site for residue SO4 B 802

Chain	Residue
B	VAL141
B	TYR244

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Functional Information from PROSITE/UniProt

site_id	PS00067
Number of Residues	25
Details	3HCDH 3-hydroxyacyl-CoA dehydrogenase signature. DkaGFYvNRilaPYIneair.MLtqG

Chain	Residue	Details
A	ASP489-GLY513

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Site: {"description":"Important for catalytic activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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