6YRP

Crystal Structure of the VIM-2 Acquired Metallo-beta-Lactamase in Complex with JMV-4690 (Cpd 31)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	HIS116
A	HIS118
A	HIS196
A	PJB404

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 402

Chain	Residue
A	ASP120
A	CYS221
A	HIS263
A	PJB404

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 403

Chain	Residue
A	HIS285
A	ACT408
A	ACT409
A	HIS170

---

site_id	AC4
Number of Residues	20
Details	binding site for residue PJB A 404

Chain	Residue
A	PHE61
A	TYR67
A	TRP87
A	HIS116
A	HIS118
A	ASP119
A	ASP120
A	HIS196
A	CYS221
A	TYR224
A	ARG228
A	GLY232
A	ASN233
A	HIS263
A	ZN401
A	ZN402
A	DMS410
A	HOH519
A	HOH527
A	HOH572

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 405

Chain	Residue
A	SER141
A	SER176
A	TYR191
A	THR198
A	ASP199

---

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO A 406

Chain	Residue
A	GLU149
A	ARG183
A	GLY185
A	PRO186

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO A 407

Chain	Residue
A	GLY150
A	ARG183
A	GLY185
A	VAL187
A	GLU188
A	PRO209
A	HOH522

---

site_id	AC8
Number of Residues	9
Details	binding site for residue ACT A 408

Chain	Residue
A	ALA135
A	THR136
A	THR169
A	HIS170
A	HIS285
A	ASN288
A	ZN403
A	ACT409
A	HOH535

---

site_id	AC9
Number of Residues	8
Details	binding site for residue ACT A 409

Chain	Residue
A	ALA135
A	HIS170
A	THR229
A	HIS285
A	ASN288
A	ZN403
A	ACT408
A	HOH506

---

site_id	AD1
Number of Residues	2
Details	binding site for residue DMS A 410

Chain	Residue
A	TYR67
A	PJB404

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