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6YQP

Crystal structure of the first bromodomain of human BRD4 in complex with the dual inhibitor TW22

Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue EDO A 201
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135

site_idAC2
Number of Residues6
Detailsbinding site for residue EDO A 202
ChainResidue
AHOH316
AHOH328
ALEU63
ALEU67
ALEU114
AASN117

site_idAC3
Number of Residues8
Detailsbinding site for residue EDO A 203
ChainResidue
ATHR73
ALYS76
ATHR134
ATYR137
AGLU154
ALYS160
AHOH339
AHOH369

site_idAC4
Number of Residues18
Detailsbinding site for residue P8N A 204
ChainResidue
APRO53
ALYS55
APRO56
ALYS57
ATRP81
APRO82
ALEU92
ALEU94
ATYR98
ALYS99
ALYS102
AASN140
AASP145
AILE146
AMET149
AHOH315
AHOH320
AHOH323

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

219869

PDB entries from 2024-05-15

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