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6YQO

Crystal structure of the first bromodomain of human BRD4 in complex with the dual inhibitor TW12

Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue EDO A 201
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135

site_idAC2
Number of Residues8
Detailsbinding site for residue EDO A 202
ChainResidue
AASN117
AHOH354
AHOH357
AHOH397
AARG58
AGLN59
ALEU63
ALEU114

site_idAC3
Number of Residues4
Detailsbinding site for residue EDO A 203
ChainResidue
ATYR137
AILE138
ALYS160
AGLU163

site_idAC4
Number of Residues10
Detailsbinding site for residue P8Q A 204
ChainResidue
APRO53
ATRP81
APRO82
ALEU92
ALYS99
AASN140
AASP145
AILE146
AMET149
AHOH313

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

221051

PDB entries from 2024-06-12

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