6YQM

Human histidine triad nucleotide-binding protein 1 (hHINT1) complexed with dGMP and refined to 1.02 A

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000118	cellular_component	histone deacetylase complex
AAA	0000166	molecular_function	nucleotide binding
AAA	0003824	molecular_function	catalytic activity
AAA	0005080	molecular_function	protein kinase C binding
AAA	0005515	molecular_function	protein binding
AAA	0005634	cellular_component	nucleus
AAA	0005654	cellular_component	nucleoplasm
AAA	0005737	cellular_component	cytoplasm
AAA	0005829	cellular_component	cytosol
AAA	0005856	cellular_component	cytoskeleton
AAA	0005886	cellular_component	plasma membrane
AAA	0006355	biological_process	regulation of DNA-templated transcription
AAA	0006508	biological_process	proteolysis
AAA	0006915	biological_process	apoptotic process
AAA	0007165	biological_process	signal transduction
AAA	0008234	molecular_function	cysteine-type peptidase activity
AAA	0009154	biological_process	purine ribonucleotide catabolic process
AAA	0016787	molecular_function	hydrolase activity
AAA	0016926	biological_process	protein desumoylation
AAA	0016929	molecular_function	deSUMOylase activity
AAA	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
AAA	0050850	biological_process	positive regulation of calcium-mediated signaling
AAA	0070062	cellular_component	extracellular exosome
AAA	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
BBB	0000118	cellular_component	histone deacetylase complex
BBB	0000166	molecular_function	nucleotide binding
BBB	0003824	molecular_function	catalytic activity
BBB	0005080	molecular_function	protein kinase C binding
BBB	0005515	molecular_function	protein binding
BBB	0005634	cellular_component	nucleus
BBB	0005654	cellular_component	nucleoplasm
BBB	0005737	cellular_component	cytoplasm
BBB	0005829	cellular_component	cytosol
BBB	0005856	cellular_component	cytoskeleton
BBB	0005886	cellular_component	plasma membrane
BBB	0006355	biological_process	regulation of DNA-templated transcription
BBB	0006508	biological_process	proteolysis
BBB	0006915	biological_process	apoptotic process
BBB	0007165	biological_process	signal transduction
BBB	0008234	molecular_function	cysteine-type peptidase activity
BBB	0009154	biological_process	purine ribonucleotide catabolic process
BBB	0016787	molecular_function	hydrolase activity
BBB	0016926	biological_process	protein desumoylation
BBB	0016929	molecular_function	deSUMOylase activity
BBB	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
BBB	0050850	biological_process	positive regulation of calcium-mediated signaling
BBB	0070062	cellular_component	extracellular exosome
BBB	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator

Functional Information from PROSITE/UniProt

site_id	PS00892
Number of Residues	19
Details	HIT_1 HIT domain signature. NegsdGgQsVyHVHLHVLG

Chain	Residue	Details
AAA	ASN99-GLY117

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Tele-AMP-histidine intermediate => ECO:0000269|PubMed:9323207

Chain	Residue	Details
AAA	HIS112
BBB	HIS112

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:22869114, ECO:0007744|PDB:3TW2

Chain	Residue	Details
AAA	ASP43
AAA	ASN99
AAA	GLY105
AAA	HIS112
BBB	ASP43
BBB	ASN99
BBB	GLY105
BBB	HIS112

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
AAA	ALA2
BBB	ALA2

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
AAA	LYS21
AAA	LYS30
BBB	LYS21
BBB	LYS30

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site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P70349

Chain	Residue	Details
AAA	SER45
AAA	SER72
BBB	SER45
BBB	SER72

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