6YQM

Human histidine triad nucleotide-binding protein 1 (hHINT1) complexed with dGMP and refined to 1.02 A

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000118	cellular_component	histone deacetylase complex
AAA	0000166	molecular_function	nucleotide binding
AAA	0003824	molecular_function	catalytic activity
AAA	0005080	molecular_function	protein kinase C binding
AAA	0005515	molecular_function	protein binding
AAA	0005634	cellular_component	nucleus
AAA	0005654	cellular_component	nucleoplasm
AAA	0005737	cellular_component	cytoplasm
AAA	0005829	cellular_component	cytosol
AAA	0005856	cellular_component	cytoskeleton
AAA	0006351	biological_process	DNA-templated transcription
AAA	0006355	biological_process	regulation of DNA-templated transcription
AAA	0006508	biological_process	proteolysis
AAA	0006915	biological_process	apoptotic process
AAA	0007165	biological_process	signal transduction
AAA	0008233	molecular_function	peptidase activity
AAA	0008234	molecular_function	cysteine-type peptidase activity
AAA	0009154	biological_process	purine ribonucleotide catabolic process
AAA	0016787	molecular_function	hydrolase activity
AAA	0016926	biological_process	protein desumoylation
AAA	0016929	molecular_function	deSUMOylase activity
AAA	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
AAA	0050850	biological_process	positive regulation of calcium-mediated signaling
AAA	0070062	cellular_component	extracellular exosome
AAA	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
BBB	0000118	cellular_component	histone deacetylase complex
BBB	0000166	molecular_function	nucleotide binding
BBB	0003824	molecular_function	catalytic activity
BBB	0005080	molecular_function	protein kinase C binding
BBB	0005515	molecular_function	protein binding
BBB	0005634	cellular_component	nucleus
BBB	0005654	cellular_component	nucleoplasm
BBB	0005737	cellular_component	cytoplasm
BBB	0005829	cellular_component	cytosol
BBB	0005856	cellular_component	cytoskeleton
BBB	0006351	biological_process	DNA-templated transcription
BBB	0006355	biological_process	regulation of DNA-templated transcription
BBB	0006508	biological_process	proteolysis
BBB	0006915	biological_process	apoptotic process
BBB	0007165	biological_process	signal transduction
BBB	0008233	molecular_function	peptidase activity
BBB	0008234	molecular_function	cysteine-type peptidase activity
BBB	0009154	biological_process	purine ribonucleotide catabolic process
BBB	0016787	molecular_function	hydrolase activity
BBB	0016926	biological_process	protein desumoylation
BBB	0016929	molecular_function	deSUMOylase activity
BBB	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
BBB	0050850	biological_process	positive regulation of calcium-mediated signaling
BBB	0070062	cellular_component	extracellular exosome
BBB	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator

Functional Information from PROSITE/UniProt

site_id	PS00892
Number of Residues	19
Details	HIT_1 HIT domain signature. NegsdGgQsVyHVHLHVLG

Chain	Residue	Details
AAA	ASN99-GLY117

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	216
Details	Domain: {"description":"HIT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00464","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"Histidine triad motif"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Tele-AMP-histidine intermediate","evidences":[{"source":"PubMed","id":"9323207","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22869114","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3TW2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P70349","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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