6YMY

Cytochrome c oxidase from Saccharomyces cerevisiae

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0004129	molecular_function	cytochrome-c oxidase activity
a	0005515	molecular_function	protein binding
a	0005739	cellular_component	mitochondrion
a	0005743	cellular_component	mitochondrial inner membrane
a	0005751	cellular_component	mitochondrial respiratory chain complex IV
a	0006119	biological_process	oxidative phosphorylation
a	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
a	0009060	biological_process	aerobic respiration
a	0015990	biological_process	electron transport coupled proton transport
a	0016020	cellular_component	membrane
a	0020037	molecular_function	heme binding
a	0031966	cellular_component	mitochondrial membrane
a	0045277	cellular_component	respiratory chain complex IV
a	0045333	biological_process	cellular respiration
a	0046872	molecular_function	metal ion binding
a	0070469	cellular_component	respirasome
b	0004129	molecular_function	cytochrome-c oxidase activity
b	0005507	molecular_function	copper ion binding
b	0005515	molecular_function	protein binding
b	0005739	cellular_component	mitochondrion
b	0005743	cellular_component	mitochondrial inner membrane
b	0005751	cellular_component	mitochondrial respiratory chain complex IV
b	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
b	0009060	biological_process	aerobic respiration
b	0016020	cellular_component	membrane
b	0016491	molecular_function	oxidoreductase activity
b	0022900	biological_process	electron transport chain
b	0042773	biological_process	ATP synthesis coupled electron transport
b	0046872	molecular_function	metal ion binding
b	0070469	cellular_component	respirasome
b	1902600	biological_process	proton transmembrane transport
c	0004129	molecular_function	cytochrome-c oxidase activity
c	0005739	cellular_component	mitochondrion
c	0005743	cellular_component	mitochondrial inner membrane
c	0005751	cellular_component	mitochondrial respiratory chain complex IV
c	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
c	0009055	molecular_function	electron transfer activity
c	0009060	biological_process	aerobic respiration
c	0016020	cellular_component	membrane
c	0019646	biological_process	aerobic electron transport chain
c	0022904	biological_process	respiratory electron transport chain
c	0031966	cellular_component	mitochondrial membrane
c	0045333	biological_process	cellular respiration
c	1902600	biological_process	proton transmembrane transport
d	0005740	cellular_component	mitochondrial envelope
d	0005751	cellular_component	mitochondrial respiratory chain complex IV
d	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
e	0005751	cellular_component	mitochondrial respiratory chain complex IV
e	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
f	0005743	cellular_component	mitochondrial inner membrane
f	0005751	cellular_component	mitochondrial respiratory chain complex IV
f	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
g	0004129	molecular_function	cytochrome-c oxidase activity
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0005751	cellular_component	mitochondrial respiratory chain complex IV
g	0006119	biological_process	oxidative phosphorylation
g	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
g	0016491	molecular_function	oxidoreductase activity
g	0031966	cellular_component	mitochondrial membrane
g	0045333	biological_process	cellular respiration
g	1902600	biological_process	proton transmembrane transport
h	0005751	cellular_component	mitochondrial respiratory chain complex IV
h	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
i	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
j	0004129	molecular_function	cytochrome-c oxidase activity
j	0005739	cellular_component	mitochondrion
j	0005743	cellular_component	mitochondrial inner membrane
j	0005751	cellular_component	mitochondrial respiratory chain complex IV
j	0005758	cellular_component	mitochondrial intermembrane space
j	0006119	biological_process	oxidative phosphorylation
j	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
j	0016491	molecular_function	oxidoreductase activity
j	0031966	cellular_component	mitochondrial membrane
j	0033617	biological_process	mitochondrial cytochrome c oxidase assembly
j	0045277	cellular_component	respiratory chain complex IV
j	0045333	biological_process	cellular respiration
j	1902600	biological_process	proton transmembrane transport
k	0005743	cellular_component	mitochondrial inner membrane
k	0005751	cellular_component	mitochondrial respiratory chain complex IV

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue CU a 601

Chain	Residue
a	HIS241
a	HIS290
a	HIS291

---

site_id	AC2
Number of Residues	23
Details	binding site for residue HEA a 602

Chain	Residue
a	ALA63
a	MET66
a	ILE67
a	TRP127
a	TYR371
a	VAL374
a	PHE377
a	HIS378
a	LEU381
a	SER382
a	LEU389
a	PHE390
a	PHE425
a	MET428
a	ARG438
a	ARG439
a	ALA461
a	PHE19
a	SER33
a	ILE36
a	ARG37
a	VAL59
a	HIS62

---

site_id	AC3
Number of Residues	20
Details	binding site for residue HEA a 603

Chain	Residue
a	TRP237
a	VAL244
a	TYR245
a	HIS290
a	HIS291
a	ILE312
a	THR316
a	GLY317
a	GLY352
a	GLY355
a	LEU358
a	ALA359
a	ASP364
a	HIS368
a	VAL373
a	HIS376
a	PHE377
a	VAL380
a	LEU381
a	ARG438

---

site_id	AC4
Number of Residues	4
Details	binding site for residue PTY a 604

Chain	Residue
a	HIS328
a	LEU339
b	MET57
e	ILE95

---

site_id	AC5
Number of Residues	10
Details	binding site for residue PTY a 605

Chain	Residue
a	PHE95
a	PRO96
a	ARG97
a	ILE98
c	HIS15
c	SER62
c	TRP65
c	GLU72
c	HIS79
c	PHE94

---

site_id	AC6
Number of Residues	8
Details	binding site for residue CN3 a 606

Chain	Residue
a	ASN406
a	LYS408
a	PHE466
a	TYR470
a	LYS487
e	PHE94
e	LYS97
h	PHE54

---

site_id	AC7
Number of Residues	6
Details	binding site for residue CUA b 301

Chain	Residue
b	HIS186
b	CYS221
b	GLU223
b	CYS225
b	HIS229
b	MET232

---

site_id	AC8
Number of Residues	4
Details	binding site for residue PTY b 302

Chain	Residue
a	PHE268
b	GLY78
b	THR80
i	LYS11

---

site_id	AC9
Number of Residues	15
Details	binding site for residue PTY b 303

Chain	Residue
a	THR354
a	PHE426
a	PHE430
b	THR19
b	PRO20
b	TYR21
b	ALA22
b	CYS23
i	TRP32
i	PHE36
i	PTY101
m	LEU51
m	PRO54
m	GLY55
m	TYR58

---

site_id	AD1
Number of Residues	10
Details	binding site for residue PTY c 301

Chain	Residue
c	LEU235
c	HIS239
c	VAL241
c	GLY242
c	PHE66
c	ILE69
c	ALA73
c	THR74
c	ARG229
c	HIS234

---

site_id	AD2
Number of Residues	16
Details	binding site for residue PCF c 302

Chain	Residue
a	SER204
a	THR208
a	PHE216
c	TYR189
c	ALA192
c	ALA193
c	PHE194
c	ILE196
c	TYR206
c	GLY210
k	TRP108
k	THR114
k	LEU115
k	PHE116
k	TRP117
k	ASN122

---

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN d 201

Chain	Residue
d	CYS111
d	HIS119
d	CYS134
d	CYS137

---

site_id	AD4
Number of Residues	2
Details	binding site for residue PTY e 201

Chain	Residue
e	PCF202
m	PCF101

---

site_id	AD5
Number of Residues	6
Details	binding site for residue PCF e 202

Chain	Residue
a	TYR452
e	ALA111
e	ARG114
e	GLY118
e	PTY201
m	PCF101

---

site_id	AD6
Number of Residues	3
Details	binding site for residue PTY i 101

Chain	Residue
b	PTY303
i	TYR31
i	PHE36

---

site_id	AD7
Number of Residues	7
Details	binding site for residue PCF m 101

Chain	Residue
a	ILE456
b	TYR21
e	PTY201
e	PCF202
m	VAL57
m	SER61
m	ALA63

---

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiliipgfgiishvvstyskkpvfgeismvyamasigllgflvws..HH

Chain	Residue	Details
a	TRP237-HIS291

---

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHdfaipslgikvdatpgrlnqvsaliqregvfyga......CselCgtgHanM

Chain	Residue	Details
b	VAL184-MET232

---

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. IMWlkptvnevarCweCGsvYKL

Chain	Residue	Details
d	ILE121-LEU143

---

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. IRsKpFfWGDGdKTlFwN

Chain	Residue	Details
k	ILE101-ASN118

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	27
Details	TRANSMEM: Helical => ECO:0000269|PubMed:30598554

Chain	Residue	Details
k	ALA44-TYR71
d	HIS119
d	CYS134
d	CYS137

---

site_id	SWS_FT_FI2
Number of Residues	57
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:30598554

Chain	Residue	Details
k	PHE72-ASP129
c	SER115-LEU137
c	TYR189-TYR201
c	TRP266-VAL269
a	ALA359-THR370
a	GLY432-GLY449

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:30598554

Chain	Residue	Details
h	LYS74

---

site_id	SWS_FT_FI4
Number of Residues	25
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000269|PubMed:30598554

Chain	Residue	Details
c	THR74-THR80
c	GLY162-ARG164
c	ARG231-ILE248
a	HIS328-ALA335
a	LEU401-ASN406
a	GLN475-SER534

---

site_id	SWS_FT_FI5
Number of Residues	33
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
c	MET81-MET114
b	CYS221
b	CYS225
b	MET232

---

site_id	SWS_FT_FI6
Number of Residues	23
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
c	PRO138-ALA161
b	HIS229

---

site_id	SWS_FT_FI7
Number of Residues	23
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
c	ASN165-GLU188

---

site_id	SWS_FT_FI8
Number of Residues	28
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
c	GLY202-MET230

---

site_id	SWS_FT_FI9
Number of Residues	16
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
c	TYR249-TYR265

---

site_id	SWS_FT_FI10
Number of Residues	28
Details	TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
a	ALA299-ILE327

---

site_id	SWS_FT_FI11
Number of Residues	22
Details	TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
a	THR336-LEU358

---

site_id	SWS_FT_FI12
Number of Residues	29
Details	TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
a	TYR371-ILE400

---

site_id	SWS_FT_FI13
Number of Residues	24
Details	TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
a	GLU407-LEU431

---

site_id	SWS_FT_FI14
Number of Residues	24
Details	TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
a	TRP450-ASP474

---

site_id	SWS_FT_FI15
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:30598554, ECO:0000269|PubMed:30598556

Chain	Residue	Details
a	GLU39
a	ALA42
a	GLY44
a	HIS241
a	HIS290
a	HIS291
a	HIS368
a	ASP369
a	PRO441

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000269|PubMed:30598554, ECO:0000269|PubMed:30598556

Chain	Residue	Details
a	HIS62
a	HIS378

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P00396

Chain	Residue	Details
a	TYR245

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	BINDING: axial binding residue => ECO:0000269|PubMed:30598554

Chain	Residue	Details
a	HIS376

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269|PubMed:30598554

Chain	Residue	Details
a	HIS241
a	TYR245

---