6YME
Crystal structure of serine hydroxymethyltransferase from Aphanothece halophytica in the PLP-internal aldimine state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006544 | biological_process | glycine metabolic process |
| A | 0006545 | biological_process | glycine biosynthetic process |
| A | 0006563 | biological_process | L-serine metabolic process |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019264 | biological_process | glycine biosynthetic process from serine |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0032259 | biological_process | methylation |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| A | 0046653 | biological_process | tetrahydrofolate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 501 |
| Chain | Residue |
| A | SER36 |
| A | HOH605 |
| A | HOH612 |
| A | TYR56 |
| A | GLU58 |
| A | TYR66 |
| A | HIS127 |
| A | SER177 |
| A | HIS205 |
| A | LLP231 |
| A | ARG363 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | GLU151 |
| A | GLU153 |
| A | LYS308 |
| A | SER311 |
| A | GLY312 |
| A | HOH979 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | GLN77 |
| A | ASP81 |
| A | LYS84 |
| A | ARG305 |
| A | ASN384 |
| A | HOH637 |
| A | HOH690 |
| A | HOH734 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | GLY213 |
| A | GLN400 |
| A | GLN404 |
| A | HOH611 |
| A | HOH640 |
| A | HOH681 |
| A | HOH713 |
| A | HOH724 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 505 |
| Chain | Residue |
| A | THR371 |
| A | ARG372 |
| A | PRO414 |
| A | LEU415 |
| A | TYR416 |
| A | HOH606 |
| A | HOH678 |
| A | HOH792 |
| A | HOH903 |
| A | HOH907 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 506 |
| Chain | Residue |
| A | THR109 |
| A | TYR198 |
| A | LYS251 |
| A | HOH900 |
Functional Information from PROSITE/UniProt
| site_id | PS00096 |
| Number of Residues | 17 |
| Details | SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. DVvTTTTHKTLrGPRGG |
| Chain | Residue | Details |
| A | ASP223-GLY239 |
