6YM8
Crystal structure of YTHDC1 with compound YLI_DC1_002
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue OYN A 601 |
| Chain | Residue |
| A | LYS361 |
| A | HOH737 |
| A | HOH781 |
| A | SER362 |
| A | ASN363 |
| A | ASN364 |
| A | ASN367 |
| A | TRP377 |
| A | SER378 |
| A | TRP428 |
| A | ASP476 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 602 |
| Chain | Residue |
| A | GLY344 |
| A | THR345 |
| A | SER346 |
| A | LYS347 |
| A | HOH707 |
| A | HOH709 |
| A | HOH716 |
| B | LYS386 |
| B | GLU479 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue OYN B 601 |
| Chain | Residue |
| B | LYS361 |
| B | SER362 |
| B | ASN363 |
| B | ASN364 |
| B | ASN367 |
| B | TRP377 |
| B | SER378 |
| B | TRP428 |
| B | PRO431 |
| B | LEU439 |
| B | ASP476 |
| B | HOH781 |
| B | HOH796 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 602 |
| Chain | Residue |
| B | ARG451 |
| B | GLU452 |
| B | HOH741 |
| B | HOH743 |
| B | HOH749 |
| B | HOH771 |
| B | HOH795 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 603 |
| Chain | Residue |
| B | GLY344 |
| B | LYS347 |
| B | HOH703 |
| B | HOH705 |
| B | HOH726 |
| B | HOH798 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 604 |
| Chain | Residue |
| B | ARG475 |
| B | ASP476 |
| B | HOH702 |
| B | HOH709 |
| B | HOH723 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 605 |
| Chain | Residue |
| B | HIS420 |
| B | HIS421 |
| B | ARG451 |
| B | HOH833 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 274 |
| Details | Domain: {"description":"YTH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00225","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31670957","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25242552","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31670957","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25242552","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
