6YKI

Crystal structure of YTHDC1 with compound DHU_DC1_092

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
B	0003723	molecular_function	RNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 A 601

Chain	Residue
A	GLY344
A	SER346
A	LYS347
A	HOH711

---

site_id	AC2
Number of Residues	10
Details	binding site for residue SO4 A 602

Chain	Residue
A	HOH743
A	HOH769
A	HOH828
B	GLY344
B	LYS347
A	GLN478
A	GLU479
A	HOH702
A	HOH719
A	HOH728

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 A 603

Chain	Residue
A	HIS420
A	HIS421
A	HOH725
A	HOH794

---

site_id	AC4
Number of Residues	7
Details	binding site for residue SO4 A 604

Chain	Residue
A	ASN367
A	TRP377
A	SER378
A	LEU439
A	HOH705
A	HOH717
A	HOH832

---

site_id	AC5
Number of Residues	8
Details	binding site for residue OUZ B 701

Chain	Residue
B	TRP377
B	SER378
B	PRO431
B	MET434
B	SER435
B	LEU439
B	SO4706
B	HOH815

---

site_id	AC6
Number of Residues	9
Details	binding site for residue OUZ B 702

Chain	Residue
A	PRO464
A	TRP465
A	HIS468
A	GLU481
B	TYR350
B	HIS427
B	TRP428
B	ILE504
B	HOH814

---

site_id	AC7
Number of Residues	7
Details	binding site for residue SO4 B 703

Chain	Residue
B	ARG451
B	GLU452
B	HOH821
B	HOH822
B	HOH826
B	HOH846
B	HOH856

---

site_id	AC8
Number of Residues	6
Details	binding site for residue SO4 B 704

Chain	Residue
B	SER419
B	HIS420
B	HIS421
B	ARG451
B	HOH854
B	HOH884

---

site_id	AC9
Number of Residues	3
Details	binding site for residue SO4 B 705

Chain	Residue
B	ARG404
B	ARG475
B	ASP476

---

site_id	AD1
Number of Residues	5
Details	binding site for residue SO4 B 706

Chain	Residue
B	SER362
B	ASN363
B	ASN367
B	OUZ701
B	HOH812

---

site_id	AD2
Number of Residues	7
Details	binding site for residue SO4 B 707

Chain	Residue
B	LYS385
B	ASN388
B	ARG392
B	LYS457
B	HOH805
B	HOH843
B	HOH920

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	274
Details	Domain: {"description":"YTH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00225","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31670957","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25242552","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31670957","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25242552","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---