6YII

Crystal structure of a Class III adenylyl cyclase-like ATP-binding protein from Pseudomonas aeruginosa

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004016	molecular_function	adenylate cyclase activity
A	0005737	cellular_component	cytoplasm
A	0009190	biological_process	cyclic nucleotide biosynthetic process
A	0016829	molecular_function	lyase activity
A	0035556	biological_process	intracellular signal transduction
A	0046872	molecular_function	metal ion binding
A	0051607	biological_process	defense response to virus

Functional Information from PDB Data

site_id	AC1
Number of Residues	30
Details	binding site for residue ATP A 601

Chain	Residue
A	LYS12
A	ILE292
A	GLY294
A	PHE295
A	THR296
A	ILE337
A	GLY338
A	ASP339
A	MN602
A	CA603
A	HOH791
A	TYR52
A	HOH803
A	HOH831
A	HOH844
A	HOH912
A	HOH948
A	HOH989
A	HOH997
A	HOH1010
A	HOH1013
A	HOH1021
A	ARG105
A	HOH1035
A	PHE178
A	ALA183
A	ASN184
A	ALA187
A	LYS188
A	ASP291

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MN A 602

Chain	Residue
A	ASP291
A	ATP601
A	HOH817
A	HOH1021

---

site_id	AC3
Number of Residues	5
Details	binding site for residue CA A 603

Chain	Residue
A	ASP291
A	ILE292
A	ASP339
A	ATP601
A	HOH1010

---

site_id	AC4
Number of Residues	8
Details	binding site for residue SO4 A 604

Chain	Residue
A	ARG170
A	SER171
A	ARG405
A	VAL413
A	ARG414
A	HOH776
A	HOH879
A	HOH952

---

site_id	AC5
Number of Residues	7
Details	binding site for residue SO4 A 605

Chain	Residue
A	ARG170
A	SER171
A	ARG332
A	ARG333
A	ARG414
A	HOH1059
A	HOH1121

---

site_id	AC6
Number of Residues	6
Details	binding site for residue SO4 A 606

Chain	Residue
A	ARG405
A	GLY410
A	ASN411
A	ARG412
A	HOH836
A	HOH926

---

site_id	AC7
Number of Residues	6
Details	binding site for residue MG A 607

Chain	Residue
A	PHE454
A	SER457
A	LYS459
A	HOH954
A	HOH1119
A	HOH1180

---

site_id	AC8
Number of Residues	6
Details	binding site for residue NA A 608

Chain	Residue
A	ASP95
A	PHE110
A	THR111
A	LYS112
A	HOH740
A	HOH842

---

site_id	AC9
Number of Residues	5
Details	binding site for residue NA A 609

Chain	Residue
A	LYS3
A	PHE329
A	SER345
A	HOH718
A	HOH1132

---

site_id	AD1
Number of Residues	5
Details	binding site for residue NA A 610

Chain	Residue
A	SER2
A	SER327
A	ASP328
A	GLU330
A	HOH1012

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	141
Details	Domain: {"description":"Guanylate cyclase 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	142
Details	Domain: {"description":"Guanylate cyclase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32454240","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34644530","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6YII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	13
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32454240","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6YII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---