6YIA
14-3-3 sigma in complex with SMAD2 pS465 peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001836 | biological_process | release of cytochrome c from mitochondria |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006469 | biological_process | negative regulation of protein kinase activity |
| A | 0006611 | biological_process | protein export from nucleus |
| A | 0007165 | biological_process | signal transduction |
| A | 0008104 | biological_process | intracellular protein localization |
| A | 0008426 | molecular_function | protein kinase C inhibitor activity |
| A | 0008630 | biological_process | intrinsic apoptotic signaling pathway in response to DNA damage |
| A | 0010482 | biological_process | regulation of epidermal cell division |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0022407 | biological_process | regulation of cell-cell adhesion |
| A | 0030307 | biological_process | positive regulation of cell growth |
| A | 0032880 | biological_process | regulation of protein localization |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045296 | molecular_function | cadherin binding |
| A | 0045606 | biological_process | positive regulation of epidermal cell differentiation |
| A | 0045785 | biological_process | positive regulation of cell adhesion |
| A | 0045824 | biological_process | negative regulation of innate immune response |
| A | 0046827 | biological_process | positive regulation of protein export from nucleus |
| A | 0050815 | molecular_function | phosphoserine residue binding |
| A | 0051219 | molecular_function | phosphoprotein binding |
| A | 0061436 | biological_process | establishment of skin barrier |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0140311 | molecular_function | protein sequestering activity |
| A | 0141156 | biological_process | cAMP/PKA signal transduction |
| A | 1903077 | biological_process | negative regulation of protein localization to plasma membrane |
| A | 1903829 | biological_process | positive regulation of protein localization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 301 |
| Chain | Residue |
| A | GLU89 |
| A | VAL134 |
| A | THR136 |
| A | HOH574 |
| A | HOH717 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 302 |
| Chain | Residue |
| A | HOH703 |
| A | HOH729 |
| A | GLU75 |
| A | GLU161 |
| A | HOH653 |
| A | HOH660 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue MG A 303 |
| Chain | Residue |
| A | GLU2 |
| A | GLU2 |
| A | HOH594 |
| A | HOH594 |
| A | HOH641 |
| A | HOH641 |
| A | HOH649 |
| A | HOH649 |
| A | HOH727 |
| A | HOH727 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 304 |
| Chain | Residue |
| A | ARG18 |
| A | GLU20 |
| A | ASP21 |
| A | HOH599 |
| A | HOH613 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 305 |
| Chain | Residue |
| A | LYS124 |
| A | ALA150 |
| A | GLU153 |
| A | HOH490 |
| A | HOH536 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 306 |
| Chain | Residue |
| A | TYR213 |
| A | THR217 |
| A | MET220 |
| A | ARG224 |
| A | HOH402 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 307 |
| Chain | Residue |
| A | LYS9 |
| A | HOH743 |
| A | HOH767 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 308 |
| Chain | Residue |
| A | GLU35 |
| A | GLU110 |
| A | GLU188 |
| A | HOH576 |
| A | HOH655 |
| A | HOH724 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue NA A 309 |
| Chain | Residue |
| A | SER146 |
| A | HOH497 |
| A | HOH536 |
| site_id | AD1 |
| Number of Residues | 14 |
| Details | binding site for Ligand residues SEP P 127 through MET P 128 bound to SER P 126 |
| Chain | Residue |
| A | LYS49 |
| A | ARG56 |
| A | ARG129 |
| A | TYR130 |
| A | LEU174 |
| A | ASN175 |
| P | SER126 |
| P | SER129 |
| P | HOH203 |
| P | HOH204 |
| P | HOH206 |
| P | HOH209 |
| P | HOH211 |
| P | HOH213 |
| site_id | AD2 |
| Number of Residues | 14 |
| Details | binding site for Ligand SEP P 127 bound to SER P 126 |
| Chain | Residue |
| A | LYS49 |
| A | ARG56 |
| A | ARG129 |
| A | TYR130 |
| A | ASN175 |
| P | SER126 |
| P | MET128 |
| P | SER129 |
| P | HOH203 |
| P | HOH204 |
| P | HOH206 |
| P | HOH209 |
| P | HOH211 |
| P | HOH213 |
Functional Information from PROSITE/UniProt
| site_id | PS00796 |
| Number of Residues | 11 |
| Details | 1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV |
| Chain | Residue | Details |
| A | ARG41-VAL51 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with phosphoserine on interacting protein"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
