6YI9

Crystal structure of the rat cytosolic PCK1, acetylated on Lys244

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0004611	molecular_function	phosphoenolpyruvate carboxykinase activity
A	0004613	molecular_function	phosphoenolpyruvate carboxykinase (GTP) activity
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0006006	biological_process	glucose metabolic process
A	0006094	biological_process	gluconeogenesis
A	0006107	biological_process	oxaloacetate metabolic process
A	0006607	biological_process	NLS-bearing protein import into nucleus
A	0006629	biological_process	lipid metabolic process
A	0009617	biological_process	response to bacterium
A	0010447	biological_process	response to acidic pH
A	0014823	biological_process	response to activity
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0017076	molecular_function	purine nucleotide binding
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0019003	molecular_function	GDP binding
A	0019543	biological_process	propionate catabolic process
A	0030145	molecular_function	manganese ion binding
A	0031406	molecular_function	carboxylic acid binding
A	0031667	biological_process	response to nutrient levels
A	0032496	biological_process	response to lipopolysaccharide
A	0032868	biological_process	response to insulin
A	0032869	biological_process	cellular response to insulin stimulus
A	0033993	biological_process	response to lipid
A	0036316	biological_process	SREBP-SCAP complex retention in endoplasmic reticulum
A	0042593	biological_process	glucose homeostasis
A	0042594	biological_process	response to starvation
A	0043382	biological_process	positive regulation of memory T cell differentiation
A	0043648	biological_process	dicarboxylic acid metabolic process
A	0045542	biological_process	positive regulation of cholesterol biosynthetic process
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
A	0046327	biological_process	glycerol biosynthetic process from pyruvate
A	0046872	molecular_function	metal ion binding
A	0046889	biological_process	positive regulation of lipid biosynthetic process
A	0046890	biological_process	regulation of lipid biosynthetic process
A	0051365	biological_process	cellular response to potassium ion starvation
A	0051604	biological_process	protein maturation
A	0070365	biological_process	hepatocyte differentiation
A	0070741	biological_process	response to interleukin-6
A	0071300	biological_process	cellular response to retinoic acid
A	0071320	biological_process	cellular response to cAMP
A	0071332	biological_process	cellular response to fructose stimulus
A	0071333	biological_process	cellular response to glucose stimulus
A	0071347	biological_process	cellular response to interleukin-1
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0071377	biological_process	cellular response to glucagon stimulus
A	0071456	biological_process	cellular response to hypoxia
A	0071474	biological_process	cellular hyperosmotic response
A	0071475	biological_process	cellular hyperosmotic salinity response
A	0071476	biological_process	cellular hypotonic response
A	0071477	biological_process	cellular hypotonic salinity response
A	0071549	biological_process	cellular response to dexamethasone stimulus
A	0072350	biological_process	tricarboxylic acid metabolic process
A	0097403	biological_process	cellular response to raffinose
A	0106264	molecular_function	protein serine kinase activity (using GTP as donor)
A	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
A	1904640	biological_process	response to methionine

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue EDO A 701

Chain	Residue
A	ALA86
A	ARG87
A	GLY236
A	GLY237
A	ALY244
A	ASN403
A	ARG405

---

site_id	AC2
Number of Residues	5
Details	binding site for residue EDO A 702

Chain	Residue
A	VAL456
A	ILE555
A	HOH948
A	TYR445
A	HIS452

---

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO A 703

Chain	Residue
A	GLY259
A	TRP260
A	LYS316
A	PHE317

---

site_id	AC4
Number of Residues	6
Details	binding site for residue EDO A 704

Chain	Residue
A	CYS288
A	GLY435
A	VAL514
A	ASN515
A	TRP516
A	PHE517

---

site_id	AC5
Number of Residues	7
Details	binding site for residue EDO A 705

Chain	Residue
A	ALA439
A	GLY440
A	ARG518
A	SER581
A	HOH819
A	HOH882
A	HOH902

---

site_id	AC6
Number of Residues	6
Details	binding site for residue EDO A 706

Chain	Residue
A	GLU41
A	TYR42
A	SER449
A	GLU611
A	ALA614
A	ARG618

---

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO A 707

Chain	Residue
A	PHE30
A	ASN34
A	PHE126
A	LEU193
A	GLU227

---

site_id	AC8
Number of Residues	4
Details	binding site for residue EDO A 708

Chain	Residue
A	GLU119
A	ARG225
A	HOH821
A	HOH833

---

site_id	AC9
Number of Residues	6
Details	binding site for residue EDO A 709

Chain	Residue
A	SER449
A	TRP450
A	PRO509
A	LYS510
A	ILE511
A	HOH860

---

site_id	AD1
Number of Residues	5
Details	binding site for residue EDO A 710

Chain	Residue
A	TRP516
A	PHE525
A	TRP527
A	PRO528
A	GLY529

---

site_id	AD2
Number of Residues	3
Details	binding site for residue EDO A 711

Chain	Residue
A	ARG543
A	TYR557
A	HOH843

---

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO A 712

Chain	Residue
A	GLU538
A	ALA563
A	LEU564
A	ASN565

---

site_id	AD4
Number of Residues	4
Details	binding site for residue EDO A 713

Chain	Residue
A	LYS155
A	GLU188
A	GLU258
A	HOH1026

---

site_id	AD5
Number of Residues	8
Details	binding site for residue EDO A 714

Chain	Residue
A	GLY309
A	ASP310
A	ASP311
A	ASN327
A	GLY331
A	PHE332
A	ALA410
A	HOH806

---

site_id	AD6
Number of Residues	3
Details	binding site for residue EDO A 715

Chain	Residue
A	GLY109
A	GLN110
A	GLY302

---

site_id	AD7
Number of Residues	5
Details	binding site for residue EDO A 716

Chain	Residue
A	ASN601
A	LEU604
A	TYR606
A	GLU609
A	HOH854

---

site_id	AD8
Number of Residues	5
Details	binding site for residue EDO A 717

Chain	Residue
A	ASP593
A	GLU597
A	LEU604
A	HOH810
A	HOH854

---

site_id	AD9
Number of Residues	5
Details	binding site for residue EDO A 718

Chain	Residue
A	GLU429
A	LYS507
A	LEU508
A	HOH817
A	HOH832

---

site_id	AE1
Number of Residues	7
Details	binding site for residue EDO A 719

Chain	Residue
A	ASN292
A	VAL335
A	PRO337
A	GLY338
A	THR339
A	HOH807
A	HOH1106

---

site_id	AE2
Number of Residues	2
Details	binding site for residue EDO A 720

Chain	Residue
A	ASP162
A	PRO164

---

Functional Information from PROSITE/UniProt

site_id	PS00505
Number of Residues	9
Details	PEPCK_GTP Phosphoenolpyruvate carboxykinase (GTP) signature. FPSACGKTN

Chain	Residue	Details
A	PHE284-ASN292

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Region: {"description":"Omega-loop","evidences":[{"source":"PubMed","id":"28345895","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2909519","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18197707","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18197707","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26322521","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26709450","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31461616","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P5O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18197707","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26322521","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26709450","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345895","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26322521","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26709450","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345895","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine; by p300/EP300","evidences":[{"source":"UniProtKB","id":"P35558","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P35558","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; by p300/EP300","evidences":[{"source":"UniProtKB","id":"P35558","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"30193097","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q16822","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q16822","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"30193097","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---