6YI0

Human histidine triad nucleotide-binding protein 2 (hHINT2) refined to 1.65 A in P41212 space group

This is a non-PDB format compatible entry.

Replaces:  4NJX

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000166	molecular_function	nucleotide binding
AAA	0003824	molecular_function	catalytic activity
AAA	0005515	molecular_function	protein binding
AAA	0005737	cellular_component	cytoplasm
AAA	0005739	cellular_component	mitochondrion
AAA	0005741	cellular_component	mitochondrial outer membrane
AAA	0005759	cellular_component	mitochondrial matrix
AAA	0006629	biological_process	lipid metabolic process
AAA	0006694	biological_process	steroid biosynthetic process
AAA	0006915	biological_process	apoptotic process
AAA	0016042	biological_process	lipid catabolic process
AAA	0016787	molecular_function	hydrolase activity
AAA	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
BBB	0000166	molecular_function	nucleotide binding
BBB	0003824	molecular_function	catalytic activity
BBB	0005515	molecular_function	protein binding
BBB	0005737	cellular_component	cytoplasm
BBB	0005739	cellular_component	mitochondrion
BBB	0005741	cellular_component	mitochondrial outer membrane
BBB	0005759	cellular_component	mitochondrial matrix
BBB	0006629	biological_process	lipid metabolic process
BBB	0006694	biological_process	steroid biosynthetic process
BBB	0006915	biological_process	apoptotic process
BBB	0016042	biological_process	lipid catabolic process
BBB	0016787	molecular_function	hydrolase activity
BBB	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
CCC	0000166	molecular_function	nucleotide binding
CCC	0003824	molecular_function	catalytic activity
CCC	0005515	molecular_function	protein binding
CCC	0005737	cellular_component	cytoplasm
CCC	0005739	cellular_component	mitochondrion
CCC	0005741	cellular_component	mitochondrial outer membrane
CCC	0005759	cellular_component	mitochondrial matrix
CCC	0006629	biological_process	lipid metabolic process
CCC	0006694	biological_process	steroid biosynthetic process
CCC	0006915	biological_process	apoptotic process
CCC	0016042	biological_process	lipid catabolic process
CCC	0016787	molecular_function	hydrolase activity
CCC	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
DDD	0000166	molecular_function	nucleotide binding
DDD	0003824	molecular_function	catalytic activity
DDD	0005515	molecular_function	protein binding
DDD	0005737	cellular_component	cytoplasm
DDD	0005739	cellular_component	mitochondrion
DDD	0005741	cellular_component	mitochondrial outer membrane
DDD	0005759	cellular_component	mitochondrial matrix
DDD	0006629	biological_process	lipid metabolic process
DDD	0006694	biological_process	steroid biosynthetic process
DDD	0006915	biological_process	apoptotic process
DDD	0016042	biological_process	lipid catabolic process
DDD	0016787	molecular_function	hydrolase activity
DDD	0043530	molecular_function	adenosine 5'-monophosphoramidase activity

Functional Information from PROSITE/UniProt

site_id	PS00892
Number of Residues	19
Details	HIT_1 HIT domain signature. NdgklGaQsVyHLHIHVLG

Chain	Residue	Details
AAA	ASN136-GLY154

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	216
Details	Domain: {"description":"HIT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00464","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Motif: {"description":"Histidine triad motif"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Tele-AMP-histidine intermediate","evidences":[{"source":"PubMed","id":"16762638","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	31
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23659632","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4INI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D0S9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---