6YCC
Structure the ananain protease from Ananas comosus covalently bound to the E64 inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue E64 A 301 |
| Chain | Residue |
| A | GLN19 |
| A | TRP66 |
| A | ALA132 |
| A | LEU155 |
| A | ASN156 |
| A | HIS157 |
| A | ALA158 |
| A | HOH406 |
| A | HOH562 |
| A | GLY23 |
| A | SER24 |
| A | CYS25 |
| A | TRP26 |
| A | TYR60 |
| A | LYS63 |
| A | GLY64 |
| A | GLY65 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | LYS39 |
| A | GLY43 |
| A | ASN44 |
| A | LEU45 |
| A | HOH494 |
| B | LYS41 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | LYS17 |
| A | ASN18 |
| A | GLU50 |
| A | HOH423 |
| A | HOH446 |
| A | HOH476 |
| A | HOH514 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 304 |
| Chain | Residue |
| A | GLY61 |
| A | CYS62 |
| A | LYS92 |
| A | HOH402 |
| A | HOH420 |
| A | HOH512 |
| A | HOH527 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 302 |
| Chain | Residue |
| A | LYS41 |
| B | LYS39 |
| B | GLY43 |
| B | ASN44 |
| B | LEU45 |
| B | HOH508 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 303 |
| Chain | Residue |
| B | GLY93 |
| B | THR94 |
| B | HOH406 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 304 |
| Chain | Residue |
| B | LYS17 |
| B | ASN18 |
| B | GLU50 |
| B | HOH438 |
| B | HOH444 |
| B | HOH486 |
| B | HOH522 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 305 |
| Chain | Residue |
| A | SER10 |
| A | LYS39 |
| A | ILE40 |
| B | SER10 |
| B | ALA12 |
| B | LYS39 |
| B | HOH422 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | binding site for Di-peptide E64 B 301 and CYS B 25 |
| Chain | Residue |
| B | GLN19 |
| B | GLY23 |
| B | SER24 |
| B | TRP26 |
| B | ALA27 |
| B | PHE28 |
| B | ALA29 |
| B | TYR60 |
| B | LYS63 |
| B | GLY64 |
| B | GLY65 |
| B | ALA132 |
| B | LEU155 |
| B | ASN156 |
| B | HIS157 |
| B | ALA158 |
| B | HOH414 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGrCGSCWAfAS |
| Chain | Residue | Details |
| A | GLN19-SER30 |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAIVIIGYG |
| Chain | Residue | Details |
| A | LEU155-GLY165 |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. FWIvRNSWgagWGegGYIrL |
| Chain | Residue | Details |
| A | PHE173-LEU192 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10088","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"31306685","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10089","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"31306685","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10090","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"31306685","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MIS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6YCC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
