6YCB
Structure the ananain protease from Ananas comosus covalently bound to with the E64 inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 300 |
| Chain | Residue |
| A | GLY61 |
| A | CYS62 |
| A | LYS63 |
| A | LYS92 |
| A | HOH402 |
| A | HOH405 |
| A | HOH420 |
| A | HOH515 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 301 |
| Chain | Residue |
| A | GLY43 |
| A | ASN44 |
| A | LEU45 |
| B | LYS41 |
| A | LYS39 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | LYS17 |
| A | ASN18 |
| A | GLU50 |
| A | HOH406 |
| A | HOH413 |
| A | HOH496 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | SER10 |
| A | GLY11 |
| A | ALA12 |
| A | LYS39 |
| A | HOH408 |
| B | SER10 |
| B | ILE40 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for residue TLA A 304 |
| Chain | Residue |
| A | ASN18 |
| A | ASN119 |
| A | TYR122 |
| A | ALA123 |
| A | ASN126 |
| A | GLY181 |
| A | ALA182 |
| A | TYR211 |
| A | HOH401 |
| A | HOH404 |
| A | HOH410 |
| A | HOH423 |
| A | HOH499 |
| A | HOH500 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue TLA A 305 |
| Chain | Residue |
| A | CYS95 |
| A | LYS96 |
| A | THR97 |
| A | ASN98 |
| A | HOH443 |
| A | HOH519 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 301 |
| Chain | Residue |
| B | LYS39 |
| B | GLY43 |
| B | ASN44 |
| B | LEU45 |
| B | HOH418 |
| B | HOH508 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 302 |
| Chain | Residue |
| B | LYS17 |
| B | ASN18 |
| B | GLU50 |
| B | HOH403 |
| B | HOH412 |
| B | HOH477 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | binding site for residue TLA B 303 |
| Chain | Residue |
| B | ASN18 |
| B | ASN119 |
| B | TYR122 |
| B | ALA123 |
| B | ASN126 |
| B | GLY181 |
| B | ALA182 |
| B | TYR211 |
| B | HOH401 |
| B | HOH402 |
| B | HOH412 |
| B | HOH424 |
| B | HOH431 |
| B | HOH447 |
| B | HOH502 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGrCGSCWAfAS |
| Chain | Residue | Details |
| A | GLN19-SER30 |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAIVIIGYG |
| Chain | Residue | Details |
| A | LEU155-GLY165 |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. FWIvRNSWgagWGegGYIrL |
| Chain | Residue | Details |
| A | PHE173-LEU192 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10088","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"31306685","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10089","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"31306685","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10090","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"31306685","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MIS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6YCC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
