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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6YBV

Structure of a human 48S translational initiation complex - eIF2-TC

Functional Information from GO Data
ChainGOidnamespacecontents
r0000423biological_processmitophagy
r0003676molecular_functionnucleic acid binding
r0003723molecular_functionRNA binding
r0003743molecular_functiontranslation initiation factor activity
r0005515molecular_functionprotein binding
r0005634cellular_componentnucleus
r0005737cellular_componentcytoplasm
r0005739cellular_componentmitochondrion
r0005829cellular_componentcytosol
r0005850cellular_componenteukaryotic translation initiation factor 2 complex
r0006412biological_processtranslation
r0006413biological_processtranslational initiation
r0006417biological_processregulation of translation
r0010494cellular_componentcytoplasmic stress granule
r0016020cellular_componentmembrane
r0032057biological_processnegative regulation of translational initiation in response to stress
r0033290cellular_componenteukaryotic 48S preinitiation complex
r0034063biological_processstress granule assembly
r0034198biological_processcellular response to amino acid starvation
r0034599biological_processcellular response to oxidative stress
r0034605biological_processcellular response to heat
r0034644biological_processcellular response to UV
r0034976biological_processresponse to endoplasmic reticulum stress
r0036490biological_processregulation of translation in response to endoplasmic reticulum stress
r0036499biological_processPERK-mediated unfolded protein response
r0043022molecular_functionribosome binding
r0043558biological_processregulation of translational initiation in response to stress
r0044207cellular_componenttranslation initiation ternary complex
r0045202cellular_componentsynapse
r0070062cellular_componentextracellular exosome
r0097250biological_processmitochondrial respirasome assembly
r0097451cellular_componentglial limiting end-foot
r0140468biological_processHRI-mediated signaling
r1904373biological_processresponse to kainic acid
r1990737biological_processresponse to manganese-induced endoplasmic reticulum stress
r2000676biological_processpositive regulation of type B pancreatic cell apoptotic process
s0001701biological_processin utero embryonic development
s0001731biological_processformation of translation preinitiation complex
s0002176biological_processmale germ cell proliferation
s0002183biological_processcytoplasmic translational initiation
s0003723molecular_functionRNA binding
s0003729molecular_functionmRNA binding
s0003743molecular_functiontranslation initiation factor activity
s0005515molecular_functionprotein binding
s0005634cellular_componentnucleus
s0005737cellular_componentcytoplasm
s0005829cellular_componentcytosol
s0005850cellular_componenteukaryotic translation initiation factor 2 complex
s0006412biological_processtranslation
s0006413biological_processtranslational initiation
s0008135molecular_functiontranslation factor activity, RNA binding
s0008270molecular_functionzinc ion binding
s0008584biological_processmale gonad development
s0031369molecular_functiontranslation initiation factor binding
s0045202cellular_componentsynapse
s0046872molecular_functionmetal ion binding
t0000049molecular_functiontRNA binding
t0000166molecular_functionnucleotide binding
t0001731biological_processformation of translation preinitiation complex
t0002183biological_processcytoplasmic translational initiation
t0003743molecular_functiontranslation initiation factor activity
t0003924molecular_functionGTPase activity
t0005515molecular_functionprotein binding
t0005525molecular_functionGTP binding
t0005634cellular_componentnucleus
t0005737cellular_componentcytoplasm
t0005829cellular_componentcytosol
t0005850cellular_componenteukaryotic translation initiation factor 2 complex
t0006412biological_processtranslation
t0006413biological_processtranslational initiation
t0008135molecular_functiontranslation factor activity, RNA binding
t0016787molecular_functionhydrolase activity
t0045296molecular_functioncadherin binding
t0070062cellular_componentextracellular exosome
t1990856molecular_functionmethionyl-initiator methionine tRNA binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsZinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P41035","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues71
DetailsDomain: {"description":"S1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00180","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by HRI","evidences":[{"source":"UniProtKB","id":"P83268","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"38340717","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues7
DetailsRegion: {"description":"G1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsRegion: {"description":"G2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues3
DetailsRegion: {"description":"G3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues3
DetailsRegion: {"description":"G4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsRegion: {"description":"G5","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P32481","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2025-08-27

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