6YBS

Structure of a human 48S translational initiation complex - head

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0002181	biological_process	cytoplasmic translation
a	0003723	molecular_function	RNA binding
a	0003735	molecular_function	structural constituent of ribosome
a	0005515	molecular_function	protein binding
a	0005654	cellular_component	nucleoplasm
a	0005730	cellular_component	nucleolus
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0005840	cellular_component	ribosome
a	0005925	cellular_component	focal adhesion
a	0006412	biological_process	translation
a	0016020	cellular_component	membrane
a	0022626	cellular_component	cytosolic ribosome
a	0022627	cellular_component	cytosolic small ribosomal subunit
a	0045202	cellular_component	synapse
a	1990904	cellular_component	ribonucleoprotein complex
b	0000028	biological_process	ribosomal small subunit assembly
b	0000056	biological_process	ribosomal small subunit export from nucleus
b	0001649	biological_process	osteoblast differentiation
b	0002181	biological_process	cytoplasmic translation
b	0003677	molecular_function	DNA binding
b	0003723	molecular_function	RNA binding
b	0003735	molecular_function	structural constituent of ribosome
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005840	cellular_component	ribosome
b	0005925	cellular_component	focal adhesion
b	0006364	biological_process	rRNA processing
b	0006412	biological_process	translation
b	0015935	cellular_component	small ribosomal subunit
b	0016020	cellular_component	membrane
b	0022626	cellular_component	cytosolic ribosome
b	0022627	cellular_component	cytosolic small ribosomal subunit
b	0042274	biological_process	ribosomal small subunit biogenesis
b	0045202	cellular_component	synapse
b	0097371	molecular_function	MDM2/MDM4 family protein binding
b	0097421	biological_process	liver regeneration
b	1901798	biological_process	positive regulation of signal transduction by p53 class mediator
b	1990904	cellular_component	ribonucleoprotein complex
b	1990948	molecular_function	ubiquitin ligase inhibitor activity
c	0001891	cellular_component	phagocytic cup
c	0001934	biological_process	positive regulation of protein phosphorylation
c	0002181	biological_process	cytoplasmic translation
c	0003723	molecular_function	RNA binding
c	0005080	molecular_function	protein kinase C binding
c	0005102	molecular_function	signaling receptor binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005737	cellular_component	cytoplasm
c	0005739	cellular_component	mitochondrion
c	0005829	cellular_component	cytosol
c	0005840	cellular_component	ribosome
c	0005886	cellular_component	plasma membrane
c	0006417	biological_process	regulation of translation
c	0006915	biological_process	apoptotic process
c	0007369	biological_process	gastrulation
c	0008047	molecular_function	enzyme activator activity
c	0008200	molecular_function	ion channel inhibitor activity
c	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
c	0010629	biological_process	negative regulation of gene expression
c	0015935	cellular_component	small ribosomal subunit
c	0016567	biological_process	protein ubiquitination
c	0017148	biological_process	negative regulation of translation
c	0019899	molecular_function	enzyme binding
c	0019903	molecular_function	protein phosphatase binding
c	0030178	biological_process	negative regulation of Wnt signaling pathway
c	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
c	0030292	molecular_function	protein tyrosine kinase inhibitor activity
c	0030308	biological_process	negative regulation of cell growth
c	0030332	molecular_function	cyclin binding
c	0030335	biological_process	positive regulation of cell migration
c	0030425	cellular_component	dendrite
c	0030496	cellular_component	midbody
c	0030971	molecular_function	receptor tyrosine kinase binding
c	0031334	biological_process	positive regulation of protein-containing complex assembly
c	0032091	biological_process	negative regulation of protein binding
c	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
c	0032880	biological_process	regulation of protein localization
c	0035591	molecular_function	signaling adaptor activity
c	0042169	molecular_function	SH2 domain binding
c	0042802	molecular_function	identical protein binding
c	0042803	molecular_function	protein homodimerization activity
c	0042998	biological_process	positive regulation of Golgi to plasma membrane protein transport
c	0043005	cellular_component	neuron projection
c	0043022	molecular_function	ribosome binding
c	0043025	cellular_component	neuronal cell body
c	0043065	biological_process	positive regulation of apoptotic process
c	0043204	cellular_component	perikaryon
c	0043547	biological_process	positive regulation of GTPase activity
c	0044297	cellular_component	cell body
c	0045182	molecular_function	translation regulator activity
c	0045296	molecular_function	cadherin binding
c	0045879	biological_process	negative regulation of smoothened signaling pathway
c	0048471	cellular_component	perinuclear region of cytoplasm
c	0048511	biological_process	rhythmic process
c	0050765	biological_process	negative regulation of phagocytosis
c	0051302	biological_process	regulation of cell division
c	0051434	molecular_function	BH3 domain binding
c	0051726	biological_process	regulation of cell cycle
c	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
c	0051901	biological_process	positive regulation of mitochondrial depolarization
c	0060090	molecular_function	molecular adaptor activity
c	0070062	cellular_component	extracellular exosome
c	0071333	biological_process	cellular response to glucose stimulus
c	0071363	biological_process	cellular response to growth factor stimulus
c	0072344	biological_process	rescue of stalled ribosome
c	0106070	biological_process	regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
c	1900102	biological_process	negative regulation of endoplasmic reticulum unfolded protein response
c	1903751	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
c	1990630	cellular_component	IRE1-RACK1-PP2A complex
c	1990904	cellular_component	ribonucleoprotein complex
c	2000114	biological_process	regulation of establishment of cell polarity
c	2000543	biological_process	positive regulation of gastrulation
c	2001125	biological_process	negative regulation of translational frameshifting
c	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
d	0000028	biological_process	ribosomal small subunit assembly
d	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
d	0002181	biological_process	cytoplasmic translation
d	0002548	biological_process	monocyte chemotaxis
d	0003723	molecular_function	RNA binding
d	0003735	molecular_function	structural constituent of ribosome
d	0005515	molecular_function	protein binding
d	0005654	cellular_component	nucleoplasm
d	0005730	cellular_component	nucleolus
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0005840	cellular_component	ribosome
d	0005925	cellular_component	focal adhesion
d	0006364	biological_process	rRNA processing
d	0006412	biological_process	translation
d	0007000	biological_process	nucleolus organization
d	0014069	cellular_component	postsynaptic density
d	0016020	cellular_component	membrane
d	0017134	molecular_function	fibroblast growth factor binding
d	0022626	cellular_component	cytosolic ribosome
d	0022627	cellular_component	cytosolic small ribosomal subunit
d	0030218	biological_process	erythrocyte differentiation
d	0030490	biological_process	maturation of SSU-rRNA
d	0031640	biological_process	killing of cells of another organism
d	0032040	cellular_component	small-subunit processome
d	0042274	biological_process	ribosomal small subunit biogenesis
d	0042802	molecular_function	identical protein binding
d	0050829	biological_process	defense response to Gram-negative bacterium
d	0060265	biological_process	positive regulation of respiratory burst involved in inflammatory response
d	0060266	biological_process	negative regulation of respiratory burst involved in inflammatory response
d	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
d	0070062	cellular_component	extracellular exosome
d	1990904	cellular_component	ribonucleoprotein complex
e	0002181	biological_process	cytoplasmic translation
e	0003723	molecular_function	RNA binding
e	0003735	molecular_function	structural constituent of ribosome
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005730	cellular_component	nucleolus
e	0005737	cellular_component	cytoplasm
e	0005783	cellular_component	endoplasmic reticulum
e	0005829	cellular_component	cytosol
e	0005840	cellular_component	ribosome
e	0006364	biological_process	rRNA processing
e	0006412	biological_process	translation
e	0014069	cellular_component	postsynaptic density
e	0015935	cellular_component	small ribosomal subunit
e	0022626	cellular_component	cytosolic ribosome
e	0022627	cellular_component	cytosolic small ribosomal subunit
e	0042274	biological_process	ribosomal small subunit biogenesis
e	0045202	cellular_component	synapse
e	0070062	cellular_component	extracellular exosome
e	1990904	cellular_component	ribonucleoprotein complex
f	0002181	biological_process	cytoplasmic translation
f	0003676	molecular_function	nucleic acid binding
f	0003723	molecular_function	RNA binding
f	0003735	molecular_function	structural constituent of ribosome
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0005840	cellular_component	ribosome
f	0005925	cellular_component	focal adhesion
f	0006412	biological_process	translation
f	0014069	cellular_component	postsynaptic density
f	0015935	cellular_component	small ribosomal subunit
f	0016020	cellular_component	membrane
f	0019843	molecular_function	rRNA binding
f	0022626	cellular_component	cytosolic ribosome
f	0022627	cellular_component	cytosolic small ribosomal subunit
f	0045202	cellular_component	synapse
f	0070062	cellular_component	extracellular exosome
f	1990904	cellular_component	ribonucleoprotein complex
h	0002181	biological_process	cytoplasmic translation
h	0003723	molecular_function	RNA binding
h	0003735	molecular_function	structural constituent of ribosome
h	0005515	molecular_function	protein binding
h	0005654	cellular_component	nucleoplasm
h	0005737	cellular_component	cytoplasm
h	0005783	cellular_component	endoplasmic reticulum
h	0005829	cellular_component	cytosol
h	0005840	cellular_component	ribosome
h	0006412	biological_process	translation
h	0015935	cellular_component	small ribosomal subunit
h	0016020	cellular_component	membrane
h	0022626	cellular_component	cytosolic ribosome
h	0022627	cellular_component	cytosolic small ribosomal subunit
h	0045202	cellular_component	synapse
h	0070062	cellular_component	extracellular exosome
h	0097371	molecular_function	MDM2/MDM4 family protein binding
h	1901798	biological_process	positive regulation of signal transduction by p53 class mediator
h	1990904	cellular_component	ribonucleoprotein complex
h	1990948	molecular_function	ubiquitin ligase inhibitor activity
i	0002181	biological_process	cytoplasmic translation
i	0003735	molecular_function	structural constituent of ribosome
i	0005654	cellular_component	nucleoplasm
i	0005737	cellular_component	cytoplasm
i	0005783	cellular_component	endoplasmic reticulum
i	0005791	cellular_component	rough endoplasmic reticulum
i	0005829	cellular_component	cytosol
i	0005840	cellular_component	ribosome
i	0005925	cellular_component	focal adhesion
i	0006412	biological_process	translation
i	0008270	molecular_function	zinc ion binding
i	0015935	cellular_component	small ribosomal subunit
i	0022626	cellular_component	cytosolic ribosome
i	0022627	cellular_component	cytosolic small ribosomal subunit
i	0046872	molecular_function	metal ion binding
i	0070062	cellular_component	extracellular exosome
i	0098556	cellular_component	cytoplasmic side of rough endoplasmic reticulum membrane
i	1990904	cellular_component	ribonucleoprotein complex
k	0002181	biological_process	cytoplasmic translation
k	0003723	molecular_function	RNA binding
k	0003735	molecular_function	structural constituent of ribosome
k	0005515	molecular_function	protein binding
k	0005615	cellular_component	extracellular space
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005730	cellular_component	nucleolus
k	0005737	cellular_component	cytoplasm
k	0005741	cellular_component	mitochondrial outer membrane
k	0005783	cellular_component	endoplasmic reticulum
k	0005789	cellular_component	endoplasmic reticulum membrane
k	0005829	cellular_component	cytosol
k	0005840	cellular_component	ribosome
k	0005886	cellular_component	plasma membrane
k	0006412	biological_process	translation
k	0008270	molecular_function	zinc ion binding
k	0010008	cellular_component	endosome membrane
k	0016020	cellular_component	membrane
k	0016567	biological_process	protein ubiquitination
k	0019941	biological_process	modification-dependent protein catabolic process
k	0022626	cellular_component	cytosolic ribosome
k	0030666	cellular_component	endocytic vesicle membrane
k	0031386	molecular_function	protein tag activity
k	0031982	cellular_component	vesicle
k	0032040	cellular_component	small-subunit processome
k	0045202	cellular_component	synapse
k	0046872	molecular_function	metal ion binding
k	0070062	cellular_component	extracellular exosome
k	1990904	cellular_component	ribonucleoprotein complex
m	0002181	biological_process	cytoplasmic translation
m	0003723	molecular_function	RNA binding
m	0003735	molecular_function	structural constituent of ribosome
m	0005515	molecular_function	protein binding
m	0005654	cellular_component	nucleoplasm
m	0005730	cellular_component	nucleolus
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0005840	cellular_component	ribosome
m	0006412	biological_process	translation
m	0016020	cellular_component	membrane
m	0022626	cellular_component	cytosolic ribosome
m	0022627	cellular_component	cytosolic small ribosomal subunit
m	0032040	cellular_component	small-subunit processome
m	0042274	biological_process	ribosomal small subunit biogenesis
m	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
m	1990145	biological_process	maintenance of translational fidelity
m	1990904	cellular_component	ribonucleoprotein complex
n	0000028	biological_process	ribosomal small subunit assembly
n	0002181	biological_process	cytoplasmic translation
n	0003723	molecular_function	RNA binding
n	0003735	molecular_function	structural constituent of ribosome
n	0005515	molecular_function	protein binding
n	0005654	cellular_component	nucleoplasm
n	0005730	cellular_component	nucleolus
n	0005737	cellular_component	cytoplasm
n	0005791	cellular_component	rough endoplasmic reticulum
n	0005829	cellular_component	cytosol
n	0005840	cellular_component	ribosome
n	0006364	biological_process	rRNA processing
n	0006412	biological_process	translation
n	0015935	cellular_component	small ribosomal subunit
n	0022626	cellular_component	cytosolic ribosome
n	0022627	cellular_component	cytosolic small ribosomal subunit
n	0030490	biological_process	maturation of SSU-rRNA
n	0032040	cellular_component	small-subunit processome
n	0042254	biological_process	ribosome biogenesis
n	0042274	biological_process	ribosomal small subunit biogenesis
n	0045202	cellular_component	synapse
n	0070062	cellular_component	extracellular exosome
n	0098556	cellular_component	cytoplasmic side of rough endoplasmic reticulum membrane
n	1990904	cellular_component	ribonucleoprotein complex
o	0001732	biological_process	formation of cytoplasmic translation initiation complex
o	0002183	biological_process	cytoplasmic translational initiation
o	0003676	molecular_function	nucleic acid binding
o	0003723	molecular_function	RNA binding
o	0003743	molecular_function	translation initiation factor activity
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005737	cellular_component	cytoplasm
o	0005829	cellular_component	cytosol
o	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
o	0006412	biological_process	translation
o	0006413	biological_process	translational initiation
o	0016282	cellular_component	eukaryotic 43S preinitiation complex
o	0033290	cellular_component	eukaryotic 48S preinitiation complex
o	0048471	cellular_component	perinuclear region of cytoplasm
o	0075525	biological_process	viral translational termination-reinitiation
V	0002181	biological_process	cytoplasmic translation
V	0003723	molecular_function	RNA binding
V	0003729	molecular_function	mRNA binding
V	0003735	molecular_function	structural constituent of ribosome
V	0005515	molecular_function	protein binding
V	0005654	cellular_component	nucleoplasm
V	0005730	cellular_component	nucleolus
V	0005737	cellular_component	cytoplasm
V	0005783	cellular_component	endoplasmic reticulum
V	0005829	cellular_component	cytosol
V	0005840	cellular_component	ribosome
V	0005925	cellular_component	focal adhesion
V	0006412	biological_process	translation
V	0006413	biological_process	translational initiation
V	0006450	biological_process	regulation of translational fidelity
V	0015935	cellular_component	small ribosomal subunit
V	0016020	cellular_component	membrane
V	0019843	molecular_function	rRNA binding
V	0022626	cellular_component	cytosolic ribosome
V	0022627	cellular_component	cytosolic small ribosomal subunit
V	0032040	cellular_component	small-subunit processome
V	0042274	biological_process	ribosomal small subunit biogenesis
V	0045202	cellular_component	synapse
V	0070062	cellular_component	extracellular exosome
V	1990904	cellular_component	ribonucleoprotein complex
x	0001732	biological_process	formation of cytoplasmic translation initiation complex
x	0002183	biological_process	cytoplasmic translational initiation
x	0002191	biological_process	cap-dependent translational initiation
x	0003723	molecular_function	RNA binding
x	0003743	molecular_function	translation initiation factor activity
x	0005515	molecular_function	protein binding
x	0005737	cellular_component	cytoplasm
x	0005829	cellular_component	cytosol
x	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
x	0006412	biological_process	translation
x	0006413	biological_process	translational initiation
x	0016020	cellular_component	membrane
x	0016282	cellular_component	eukaryotic 43S preinitiation complex
x	0033290	cellular_component	eukaryotic 48S preinitiation complex
x	0045202	cellular_component	synapse
x	0071541	cellular_component	eukaryotic translation initiation factor 3 complex, eIF3m
x	0075522	biological_process	IRES-dependent viral translational initiation
x	0075525	biological_process	viral translational termination-reinitiation
x	0098808	molecular_function	mRNA cap binding
X	0002181	biological_process	cytoplasmic translation
X	0003723	molecular_function	RNA binding
X	0003735	molecular_function	structural constituent of ribosome
X	0005654	cellular_component	nucleoplasm
X	0005730	cellular_component	nucleolus
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005840	cellular_component	ribosome
X	0005925	cellular_component	focal adhesion
X	0006364	biological_process	rRNA processing
X	0006412	biological_process	translation
X	0006413	biological_process	translational initiation
X	0016020	cellular_component	membrane
X	0022626	cellular_component	cytosolic ribosome
X	0022627	cellular_component	cytosolic small ribosomal subunit
X	0032040	cellular_component	small-subunit processome
X	0034101	biological_process	erythrocyte homeostasis
X	0042274	biological_process	ribosomal small subunit biogenesis
X	1990904	cellular_component	ribonucleoprotein complex
Y	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Y	0002181	biological_process	cytoplasmic translation
Y	0003723	molecular_function	RNA binding
Y	0003735	molecular_function	structural constituent of ribosome
Y	0005515	molecular_function	protein binding
Y	0005654	cellular_component	nucleoplasm
Y	0005730	cellular_component	nucleolus
Y	0005737	cellular_component	cytoplasm
Y	0005783	cellular_component	endoplasmic reticulum
Y	0005829	cellular_component	cytosol
Y	0005840	cellular_component	ribosome
Y	0005925	cellular_component	focal adhesion
Y	0006364	biological_process	rRNA processing
Y	0006412	biological_process	translation
Y	0015935	cellular_component	small ribosomal subunit
Y	0016020	cellular_component	membrane
Y	0022626	cellular_component	cytosolic ribosome
Y	0022627	cellular_component	cytosolic small ribosomal subunit
Y	0032040	cellular_component	small-subunit processome
Y	0042274	biological_process	ribosomal small subunit biogenesis
Y	0045202	cellular_component	synapse
Y	0070062	cellular_component	extracellular exosome
Y	1990904	cellular_component	ribonucleoprotein complex
Z	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
Z	0002181	biological_process	cytoplasmic translation
Z	0002183	biological_process	cytoplasmic translational initiation
Z	0003677	molecular_function	DNA binding
Z	0003684	molecular_function	damaged DNA binding
Z	0003723	molecular_function	RNA binding
Z	0003729	molecular_function	mRNA binding
Z	0003735	molecular_function	structural constituent of ribosome
Z	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
Z	0004520	molecular_function	DNA endonuclease activity
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005730	cellular_component	nucleolus
Z	0005737	cellular_component	cytoplasm
Z	0005743	cellular_component	mitochondrial inner membrane
Z	0005759	cellular_component	mitochondrial matrix
Z	0005783	cellular_component	endoplasmic reticulum
Z	0005819	cellular_component	spindle
Z	0005829	cellular_component	cytosol
Z	0005840	cellular_component	ribosome
Z	0005886	cellular_component	plasma membrane
Z	0005925	cellular_component	focal adhesion
Z	0006281	biological_process	DNA repair
Z	0006284	biological_process	base-excision repair
Z	0006351	biological_process	DNA-templated transcription
Z	0006412	biological_process	translation
Z	0006417	biological_process	regulation of translation
Z	0006915	biological_process	apoptotic process
Z	0006974	biological_process	DNA damage response
Z	0007059	biological_process	chromosome segregation
Z	0008017	molecular_function	microtubule binding
Z	0010628	biological_process	positive regulation of gene expression
Z	0014069	cellular_component	postsynaptic density
Z	0015631	molecular_function	tubulin binding
Z	0015935	cellular_component	small ribosomal subunit
Z	0016020	cellular_component	membrane
Z	0016829	molecular_function	lyase activity
Z	0017148	biological_process	negative regulation of translation
Z	0019104	molecular_function	DNA N-glycosylase activity
Z	0019899	molecular_function	enzyme binding
Z	0019900	molecular_function	kinase binding
Z	0019901	molecular_function	protein kinase binding
Z	0022626	cellular_component	cytosolic ribosome
Z	0022627	cellular_component	cytosolic small ribosomal subunit
Z	0030544	molecular_function	Hsp70 protein binding
Z	0031116	biological_process	positive regulation of microtubule polymerization
Z	0031397	biological_process	negative regulation of protein ubiquitination
Z	0032357	molecular_function	oxidized purine DNA binding
Z	0032358	molecular_function	oxidized pyrimidine DNA binding
Z	0032587	cellular_component	ruffle membrane
Z	0034614	biological_process	cellular response to reactive oxygen species
Z	0042981	biological_process	regulation of apoptotic process
Z	0044390	molecular_function	ubiquitin-like protein conjugating enzyme binding
Z	0045202	cellular_component	synapse
Z	0045738	biological_process	negative regulation of DNA repair
Z	0045739	biological_process	positive regulation of DNA repair
Z	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Z	0051018	molecular_function	protein kinase A binding
Z	0051225	biological_process	spindle assembly
Z	0051301	biological_process	cell division
Z	0051536	molecular_function	iron-sulfur cluster binding
Z	0051879	molecular_function	Hsp90 protein binding
Z	0061481	biological_process	response to TNF agonist
Z	0070062	cellular_component	extracellular exosome
Z	0070181	molecular_function	small ribosomal subunit rRNA binding
Z	0070301	biological_process	cellular response to hydrogen peroxide
Z	0071159	cellular_component	NF-kappaB complex
Z	0072686	cellular_component	mitotic spindle
Z	0097100	molecular_function	supercoiled DNA binding
Z	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Z	0140297	molecular_function	DNA-binding transcription factor binding
Z	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
Z	1902231	biological_process	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Z	1905053	biological_process	positive regulation of base-excision repair
Z	1990904	cellular_component	ribonucleoprotein complex
Z	2000144	biological_process	positive regulation of DNA-templated transcription initiation
Z	2001235	biological_process	positive regulation of apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00712
Number of Residues	16
Details	RIBOSOMAL_S17E Ribosomal protein S17e signature. IpSKkLRNkIAGYvTH

Chain	Residue	Details
X	ILE41-HIS56

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site_id	PS00527
Number of Residues	23
Details	RIBOSOMAL_S14 Ribosomal protein S14 signature. RvCsnrhglirkyg.LNMCRqCFR

Chain	Residue	Details
i	ARG22-ARG44

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site_id	PS00628
Number of Residues	20
Details	RIBOSOMAL_S19E Ribosomal protein S19e signature. PshfsrgSksVaRrVLQaLE

Chain	Residue	Details
d	PRO89-GLU108

---

site_id	PS00323
Number of Residues	25
Details	RIBOSOMAL_S19 Ribosomal protein S19 signature. NGKtfnqveIkpemIGhyLGEFsiT

Chain	Residue	Details
b	ASN98-THR122

---

site_id	PS00361
Number of Residues	16
Details	RIBOSOMAL_S10 Ribosomal protein S10 signature. AkekNLkvkGPVrMPT

Chain	Residue	Details
h	ALA43-THR58

---

site_id	PS00646
Number of Residues	14
Details	RIBOSOMAL_S13_1 Ribosomal protein S13 signature. RGlRHfwGlrVRGQ

Chain	Residue	Details
f	ARG121-GLN134

---

site_id	PS00961
Number of Residues	9
Details	RIBOSOMAL_S28E Ribosomal protein S28e signature. ESEREARrL

Chain	Residue	Details
n	GLU60-LEU68

---

site_id	PS00052
Number of Residues	27
Details	RIBOSOMAL_S7 Ribosomal protein S7 signature. ErLtnsMMmhgrnnGKKlmtvrIVkhA

Chain	Residue	Details
V	GLU70-ALA96

---

site_id	PS00360
Number of Residues	19
Details	RIBOSOMAL_S9 Ribosomal protein S9 signature. GGGhvAQiyAirqSiSKAL

Chain	Residue	Details
Y	GLY74-LEU92

---

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
k	LYS27-ASP52

---

site_id	PS00548
Number of Residues	37
Details	RIBOSOMAL_S3 Ribosomal protein S3 signature. AKsmkfvdGlMihSgdpVnyyVDtavrhvlLrqGvlG

Chain	Residue	Details
Z	ALA147-GLY183

---

site_id	PS01189
Number of Residues	19
Details	RIBOSOMAL_S12E Ribosomal protein S12e signature. ALQevLktAlihDGLarGI

Chain	Residue	Details
m	ALA17-ILE35

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. ALSGswDgTLRLWDL

Chain	Residue	Details
c	ALA78-LEU92
c	ILE120-THR134
c	ILE165-LEU179
c	CYS207-LEU221

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Region: {"description":"RNA gate","evidences":[{"source":"UniProtKB","id":"K7IM66","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	31
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	30
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	30
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	32
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	30
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	29
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	30
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N-acetylthreonine; in Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2006","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Kanor S.","Tissot J.-D.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by ABL1","evidences":[{"source":"PubMed","id":"19423701","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	9
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P68040","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"11279199","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by viral VacV B1 kinase","evidences":[{"source":"PubMed","id":"28636603","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by viral VacV B1 kinase","evidences":[{"source":"PubMed","id":"28636603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by viral VacV B1 kinase","evidences":[{"source":"PubMed","id":"28636603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	7
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P63276","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P60867","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P63325","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P63323","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25957688","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5A2Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AJ0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25957688","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5A2Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AJ0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FLX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LKS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25957688","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5A2Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AJ0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LKS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	2
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	71
Details	Domain: {"description":"KH type-2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00118","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Murray L.","Brunton V.G.","Frame M.C.","Calvo F.","Kolch W."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKC/PRKCD","evidences":[{"source":"PubMed","id":"19059439","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by MAPK","evidences":[{"source":"PubMed","id":"15950189","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	3
Details	Modified residue: {"description":"Asymmetric dimethylarginine; by PRMT1","evidences":[{"source":"PubMed","id":"19460357","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by PKB","evidences":[{"source":"PubMed","id":"20605787","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P62908","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by IKKB","evidences":[{"source":"PubMed","id":"21399639","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by CDK1 and PKC/PRKCD","evidences":[{"source":"PubMed","id":"19059439","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21871177","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16807684","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"28065601","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28132843","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31981475","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32011234","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34348161","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34469731","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9CZX8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9CZX8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62852","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	5
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	23
Details	Zinc finger: {"description":"C4-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36638793","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---