6Y91

Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with NADH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
A	0006089	biological_process	lactate metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0019752	biological_process	carboxylic acid metabolic process
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
B	0006089	biological_process	lactate metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0019752	biological_process	carboxylic acid metabolic process
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
C	0006089	biological_process	lactate metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0019752	biological_process	carboxylic acid metabolic process
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
D	0006089	biological_process	lactate metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0019752	biological_process	carboxylic acid metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue NAD A 401

Chain	Residue
A	GLY10
A	ILE97
A	VAL117
A	SER118
A	ASN119
A	LEU121
A	MET142
A	HIS174
A	HOH515
A	GLN11
A	ILE12
A	ASP32
A	VAL33
A	VAL34
A	THR76
A	ALA77
A	GLY78

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site_id	AC2
Number of Residues	18
Details	binding site for residue NAD B 401

Chain	Residue
B	GLY10
B	GLN11
B	ILE12
B	TYR31
B	ASP32
B	VAL33
B	THR76
B	ALA77
B	GLY78
B	VAL79
B	ILE97
B	VAL117
B	ASN119
B	LEU121
B	MET142
B	LEU146
B	HIS174
B	HOH512

---

site_id	AC3
Number of Residues	19
Details	binding site for residue NAD C 401

Chain	Residue
A	GLN63
A	GLU65
C	GLY10
C	GLN11
C	ILE12
C	ASP32
C	VAL33
C	VAL34
C	THR76
C	ALA77
C	GLY78
C	ILE97
C	VAL117
C	SER118
C	ASN119
C	LEU121
C	MET142
C	LEU146
C	HOH519

---

site_id	AC4
Number of Residues	17
Details	binding site for residue NAD D 401

Chain	Residue
D	GLY10
D	GLN11
D	ILE12
D	TYR31
D	ASP32
D	VAL33
D	VAL34
D	THR76
D	ALA77
D	GLY78
D	ILE97
D	VAL117
D	ASN119
D	LEU121
D	MET142
D	LEU146
D	HIS174

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