6Y87

Crystal Structure of the Homospermidine Synthase (HSS) from Pseudomonas aeruginosa in Complex with NAD and PUT

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0016740	molecular_function	transferase activity
A	0047296	molecular_function	homospermidine synthase activity
B	0000166	molecular_function	nucleotide binding
B	0016740	molecular_function	transferase activity
B	0047296	molecular_function	homospermidine synthase activity
C	0000166	molecular_function	nucleotide binding
C	0016740	molecular_function	transferase activity
C	0047296	molecular_function	homospermidine synthase activity
D	0000166	molecular_function	nucleotide binding
D	0016740	molecular_function	transferase activity
D	0047296	molecular_function	homospermidine synthase activity
E	0000166	molecular_function	nucleotide binding
E	0016740	molecular_function	transferase activity
E	0047296	molecular_function	homospermidine synthase activity
F	0000166	molecular_function	nucleotide binding
F	0016740	molecular_function	transferase activity
F	0047296	molecular_function	homospermidine synthase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	binding site for residue NAD A 501

Chain	Residue
A	GLY17
A	SER88
A	THR89
A	THR110
A	CYS111
A	GLU113
A	GLY156
A	ALA157
A	ASN158
A	PRO159
A	VAL395
A	THR18
A	PUT502
A	HOH609
A	HOH634
A	HOH644
A	HOH703
A	ILE19
A	ILE41
A	ASP42
A	PRO43
A	LYS44
A	ILE65
A	LEU87

---

site_id	AC2
Number of Residues	5
Details	binding site for residue PUT A 502

Chain	Residue
A	ASN158
A	GLU206
A	GLU233
A	HIS292
A	NAD501

---

site_id	AC3
Number of Residues	21
Details	binding site for residue NAD B 501

Chain	Residue
B	GLY17
B	THR18
B	ILE19
B	ASP42
B	PRO43
B	ILE65
B	LEU87
B	SER88
B	THR89
B	VAL91
B	THR110
B	CYS111
B	GLY156
B	ALA157
B	ASN158
B	PRO159
B	VAL395
B	HOH641
B	HOH664
B	HOH703
B	HOH711

---

site_id	AC4
Number of Residues	23
Details	binding site for residue NAD C 501

Chain	Residue
C	GLY17
C	THR18
C	ILE19
C	ASP42
C	PRO43
C	LYS44
C	ILE65
C	LEU87
C	SER88
C	THR89
C	VAL91
C	THR110
C	CYS111
C	GLY156
C	ALA157
C	ASN158
C	PRO159
C	SER226
C	VAL395
C	PUT502
C	HOH612
C	HOH646
C	HOH675

---

site_id	AC5
Number of Residues	6
Details	binding site for residue PUT C 502

Chain	Residue
C	ASN158
C	GLU206
C	TRP225
C	GLU233
C	HIS292
C	NAD501

---

site_id	AC6
Number of Residues	24
Details	binding site for residue NAD D 501

Chain	Residue
D	HOH634
D	HOH648
D	HOH684
D	HOH698
D	GLY17
D	THR18
D	ILE19
D	ASP42
D	PRO43
D	ILE65
D	LEU87
D	SER88
D	THR89
D	VAL91
D	THR110
D	CYS111
D	GLY156
D	ALA157
D	ASN158
D	PRO159
D	SER226
D	VAL395
D	HOH605
D	HOH629

---

site_id	AC7
Number of Residues	27
Details	binding site for residue NAD E 501

Chain	Residue
E	GLY17
E	THR18
E	ILE19
E	ASP42
E	PRO43
E	LYS44
E	ILE65
E	LEU87
E	SER88
E	THR89
E	VAL91
E	THR110
E	GLU113
E	GLY156
E	ALA157
E	ASN158
E	PRO159
E	SER226
E	VAL395
E	PUT502
E	HOH604
E	HOH612
E	HOH616
E	HOH620
E	HOH674
E	HOH775
E	HOH787

---

site_id	AC8
Number of Residues	6
Details	binding site for residue PUT E 502

Chain	Residue
E	ASN158
E	GLU206
E	TRP225
E	GLU233
E	HIS292
E	NAD501

---

site_id	AC9
Number of Residues	25
Details	binding site for residue NAD F 501

Chain	Residue
F	LEU16
F	GLY17
F	THR18
F	ILE19
F	ASP42
F	PRO43
F	LYS44
F	ILE65
F	LEU87
F	SER88
F	THR89
F	VAL91
F	THR110
F	GLY156
F	ALA157
F	ASN158
F	PRO159
F	SER226
F	VAL395
F	HOH601
F	HOH602
F	HOH634
F	HOH688
F	HOH699
F	HOH781

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