6Y7H

Structure of the BRD9 bromodomain and compound 11

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue OFK A 700

Chain	Residue
A	PHE160
A	PHE161
A	ILE169
A	ASN216
A	TYR222
A	LYS239
A	EDO701
A	EDO703
A	HOH808

---

site_id	AC2
Number of Residues	6
Details	binding site for residue EDO A 701

Chain	Residue
A	ILE169
A	LYS239
A	LYS246
A	OFK700
A	EDO702
A	HOH865

---

site_id	AC3
Number of Residues	3
Details	binding site for residue EDO A 702

Chain	Residue
A	LYS246
A	EDO701
A	HOH836

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 703

Chain	Residue
A	TYR222
A	LYS239
A	OFK700
A	HOH827

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO A 704

Chain	Residue
A	HIS147
A	ARG150
A	GLN151

---

site_id	AC6
Number of Residues	6
Details	binding site for residue OFK B 700

Chain	Residue
B	PHE160
B	PHE161
B	ILE169
B	ASN216
B	TYR222
B	HOH804

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Region: {"description":"Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding","evidences":[{"source":"PubMed","id":"26365797","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Site: {"description":"Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding","evidences":[{"source":"PubMed","id":"26365797","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---