6Y5Q

human 17S U2 snRNP

Functional Information from GO Data

Chain	GOid	namespace	contents
6	0000387	biological_process	spliceosomal snRNP assembly
6	0000389	biological_process	mRNA 3'-splice site recognition
6	0000398	biological_process	mRNA splicing, via spliceosome
6	0003723	molecular_function	RNA binding
6	0005515	molecular_function	protein binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005681	cellular_component	spliceosomal complex
6	0005684	cellular_component	U2-type spliceosomal complex
6	0005686	cellular_component	U2 snRNP
6	0006396	biological_process	RNA processing
6	0006397	biological_process	mRNA processing
6	0008380	biological_process	RNA splicing
6	0016607	cellular_component	nuclear speck
6	0045292	biological_process	mRNA cis splicing, via spliceosome
6	0071004	cellular_component	U2-type prespliceosome
6	0071005	cellular_component	U2-type precatalytic spliceosome
6	0071013	cellular_component	catalytic step 2 spliceosome
6	1903241	biological_process	U2-type prespliceosome assembly
7	0000245	biological_process	spliceosomal complex assembly
7	0000387	biological_process	spliceosomal snRNP assembly
7	0000389	biological_process	mRNA 3'-splice site recognition
7	0000398	biological_process	mRNA splicing, via spliceosome
7	0003676	molecular_function	nucleic acid binding
7	0003723	molecular_function	RNA binding
7	0005515	molecular_function	protein binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005681	cellular_component	spliceosomal complex
7	0005684	cellular_component	U2-type spliceosomal complex
7	0005686	cellular_component	U2 snRNP
7	0006397	biological_process	mRNA processing
7	0008270	molecular_function	zinc ion binding
7	0008380	biological_process	RNA splicing
7	0010976	biological_process	positive regulation of neuron projection development
7	0016607	cellular_component	nuclear speck
7	0046872	molecular_function	metal ion binding
7	0071004	cellular_component	U2-type prespliceosome
7	0071005	cellular_component	U2-type precatalytic spliceosome
7	0071013	cellular_component	catalytic step 2 spliceosome
7	1903241	biological_process	U2-type prespliceosome assembly
8	0000387	biological_process	spliceosomal snRNP assembly
8	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
8	0000398	biological_process	mRNA splicing, via spliceosome
8	0003723	molecular_function	RNA binding
8	0005515	molecular_function	protein binding
8	0005634	cellular_component	nucleus
8	0005654	cellular_component	nucleoplasm
8	0005681	cellular_component	spliceosomal complex
8	0005684	cellular_component	U2-type spliceosomal complex
8	0005686	cellular_component	U2 snRNP
8	0005689	cellular_component	U12-type spliceosomal complex
8	0006397	biological_process	mRNA processing
8	0008380	biological_process	RNA splicing
8	0016607	cellular_component	nuclear speck
8	0071005	cellular_component	U2-type precatalytic spliceosome
8	0071011	cellular_component	precatalytic spliceosome
8	0071013	cellular_component	catalytic step 2 spliceosome
8	1903241	biological_process	U2-type prespliceosome assembly
9	0000375	biological_process	RNA splicing, via transesterification reactions
9	0000387	biological_process	spliceosomal snRNP assembly
9	0000389	biological_process	mRNA 3'-splice site recognition
9	0000398	biological_process	mRNA splicing, via spliceosome
9	0003676	molecular_function	nucleic acid binding
9	0003723	molecular_function	RNA binding
9	0005515	molecular_function	protein binding
9	0005634	cellular_component	nucleus
9	0005654	cellular_component	nucleoplasm
9	0005681	cellular_component	spliceosomal complex
9	0005684	cellular_component	U2-type spliceosomal complex
9	0005686	cellular_component	U2 snRNP
9	0006397	biological_process	mRNA processing
9	0008270	molecular_function	zinc ion binding
9	0008380	biological_process	RNA splicing
9	0016607	cellular_component	nuclear speck
9	0046872	molecular_function	metal ion binding
9	0071005	cellular_component	U2-type precatalytic spliceosome
9	0071013	cellular_component	catalytic step 2 spliceosome
9	1903241	biological_process	U2-type prespliceosome assembly
a	0000387	biological_process	spliceosomal snRNP assembly
a	0000398	biological_process	mRNA splicing, via spliceosome
a	0003723	molecular_function	RNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005681	cellular_component	spliceosomal complex
a	0005684	cellular_component	U2-type spliceosomal complex
a	0005686	cellular_component	U2 snRNP
a	0006397	biological_process	mRNA processing
a	0007283	biological_process	spermatogenesis
a	0008380	biological_process	RNA splicing
a	0016604	cellular_component	nuclear body
a	0016607	cellular_component	nuclear speck
a	0030532	cellular_component	small nuclear ribonucleoprotein complex
a	0030620	molecular_function	U2 snRNA binding
a	0071005	cellular_component	U2-type precatalytic spliceosome
a	0071007	cellular_component	U2-type catalytic step 2 spliceosome
a	0071013	cellular_component	catalytic step 2 spliceosome
a	1903241	biological_process	U2-type prespliceosome assembly
a	1990904	cellular_component	ribonucleoprotein complex
b	0000387	biological_process	spliceosomal snRNP assembly
b	0000398	biological_process	mRNA splicing, via spliceosome
b	0003676	molecular_function	nucleic acid binding
b	0003723	molecular_function	RNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005681	cellular_component	spliceosomal complex
b	0005684	cellular_component	U2-type spliceosomal complex
b	0005685	cellular_component	U1 snRNP
b	0005686	cellular_component	U2 snRNP
b	0006397	biological_process	mRNA processing
b	0008380	biological_process	RNA splicing
b	0016607	cellular_component	nuclear speck
b	0030619	molecular_function	U1 snRNA binding
b	0071005	cellular_component	U2-type precatalytic spliceosome
b	0071007	cellular_component	U2-type catalytic step 2 spliceosome
b	0071013	cellular_component	catalytic step 2 spliceosome
b	0097525	cellular_component	spliceosomal snRNP complex
b	1903241	biological_process	U2-type prespliceosome assembly
b	1990904	cellular_component	ribonucleoprotein complex
h	0000244	biological_process	spliceosomal tri-snRNP complex assembly
h	0000245	biological_process	spliceosomal complex assembly
h	0000387	biological_process	spliceosomal snRNP assembly
h	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
h	0000398	biological_process	mRNA splicing, via spliceosome
h	0003723	molecular_function	RNA binding
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005681	cellular_component	spliceosomal complex
h	0005682	cellular_component	U5 snRNP
h	0005684	cellular_component	U2-type spliceosomal complex
h	0005685	cellular_component	U1 snRNP
h	0005686	cellular_component	U2 snRNP
h	0005687	cellular_component	U4 snRNP
h	0005689	cellular_component	U12-type spliceosomal complex
h	0005829	cellular_component	cytosol
h	0006397	biological_process	mRNA processing
h	0008380	biological_process	RNA splicing
h	0030532	cellular_component	small nuclear ribonucleoprotein complex
h	0034709	cellular_component	methylosome
h	0034715	cellular_component	pICln-Sm protein complex
h	0034719	cellular_component	SMN-Sm protein complex
h	0036261	biological_process	7-methylguanosine cap hypermethylation
h	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
h	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
h	0070062	cellular_component	extracellular exosome
h	0071005	cellular_component	U2-type precatalytic spliceosome
h	0071007	cellular_component	U2-type catalytic step 2 spliceosome
h	0071011	cellular_component	precatalytic spliceosome
h	0071013	cellular_component	catalytic step 2 spliceosome
h	0097525	cellular_component	spliceosomal snRNP complex
h	1903241	biological_process	U2-type prespliceosome assembly
h	1990904	cellular_component	ribonucleoprotein complex
i	0000244	biological_process	spliceosomal tri-snRNP complex assembly
i	0000245	biological_process	spliceosomal complex assembly
i	0000387	biological_process	spliceosomal snRNP assembly
i	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
i	0000398	biological_process	mRNA splicing, via spliceosome
i	0003723	molecular_function	RNA binding
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005681	cellular_component	spliceosomal complex
i	0005683	cellular_component	U7 snRNP
i	0005684	cellular_component	U2-type spliceosomal complex
i	0005685	cellular_component	U1 snRNP
i	0005687	cellular_component	U4 snRNP
i	0005689	cellular_component	U12-type spliceosomal complex
i	0005829	cellular_component	cytosol
i	0006397	biological_process	mRNA processing
i	0008380	biological_process	RNA splicing
i	0022618	biological_process	protein-RNA complex assembly
i	0030532	cellular_component	small nuclear ribonucleoprotein complex
i	0034709	cellular_component	methylosome
i	0034715	cellular_component	pICln-Sm protein complex
i	0034719	cellular_component	SMN-Sm protein complex
i	0036261	biological_process	7-methylguanosine cap hypermethylation
i	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
i	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
i	0071005	cellular_component	U2-type precatalytic spliceosome
i	0071007	cellular_component	U2-type catalytic step 2 spliceosome
i	0071013	cellular_component	catalytic step 2 spliceosome
i	0071045	biological_process	nuclear histone mRNA catabolic process
i	1903241	biological_process	U2-type prespliceosome assembly
i	1990904	cellular_component	ribonucleoprotein complex
j	0000244	biological_process	spliceosomal tri-snRNP complex assembly
j	0000245	biological_process	spliceosomal complex assembly
j	0000387	biological_process	spliceosomal snRNP assembly
j	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
j	0000398	biological_process	mRNA splicing, via spliceosome
j	0003723	molecular_function	RNA binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005681	cellular_component	spliceosomal complex
j	0005682	cellular_component	U5 snRNP
j	0005683	cellular_component	U7 snRNP
j	0005684	cellular_component	U2-type spliceosomal complex
j	0005685	cellular_component	U1 snRNP
j	0005686	cellular_component	U2 snRNP
j	0005687	cellular_component	U4 snRNP
j	0005689	cellular_component	U12-type spliceosomal complex
j	0005697	cellular_component	telomerase holoenzyme complex
j	0005829	cellular_component	cytosol
j	0006397	biological_process	mRNA processing
j	0008380	biological_process	RNA splicing
j	0030532	cellular_component	small nuclear ribonucleoprotein complex
j	0034709	cellular_component	methylosome
j	0034715	cellular_component	pICln-Sm protein complex
j	0034719	cellular_component	SMN-Sm protein complex
j	0036261	biological_process	7-methylguanosine cap hypermethylation
j	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
j	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
j	0071005	cellular_component	U2-type precatalytic spliceosome
j	0071007	cellular_component	U2-type catalytic step 2 spliceosome
j	0071011	cellular_component	precatalytic spliceosome
j	0071013	cellular_component	catalytic step 2 spliceosome
j	0071045	biological_process	nuclear histone mRNA catabolic process
j	1903241	biological_process	U2-type prespliceosome assembly
j	1990904	cellular_component	ribonucleoprotein complex
k	0000244	biological_process	spliceosomal tri-snRNP complex assembly
k	0000245	biological_process	spliceosomal complex assembly
k	0000387	biological_process	spliceosomal snRNP assembly
k	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
k	0000398	biological_process	mRNA splicing, via spliceosome
k	0003723	molecular_function	RNA binding
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005681	cellular_component	spliceosomal complex
k	0005682	cellular_component	U5 snRNP
k	0005683	cellular_component	U7 snRNP
k	0005684	cellular_component	U2-type spliceosomal complex
k	0005685	cellular_component	U1 snRNP
k	0005686	cellular_component	U2 snRNP
k	0005687	cellular_component	U4 snRNP
k	0005689	cellular_component	U12-type spliceosomal complex
k	0005829	cellular_component	cytosol
k	0006397	biological_process	mRNA processing
k	0008380	biological_process	RNA splicing
k	0030532	cellular_component	small nuclear ribonucleoprotein complex
k	0034709	cellular_component	methylosome
k	0034719	cellular_component	SMN-Sm protein complex
k	0036261	biological_process	7-methylguanosine cap hypermethylation
k	0043186	cellular_component	P granule
k	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
k	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
k	0071004	cellular_component	U2-type prespliceosome
k	0071005	cellular_component	U2-type precatalytic spliceosome
k	0071007	cellular_component	U2-type catalytic step 2 spliceosome
k	0071011	cellular_component	precatalytic spliceosome
k	0071013	cellular_component	catalytic step 2 spliceosome
k	0071045	biological_process	nuclear histone mRNA catabolic process
k	0097526	cellular_component	spliceosomal tri-snRNP complex
k	1903241	biological_process	U2-type prespliceosome assembly
k	1990904	cellular_component	ribonucleoprotein complex
l	0000243	cellular_component	commitment complex
l	0000244	biological_process	spliceosomal tri-snRNP complex assembly
l	0000245	biological_process	spliceosomal complex assembly
l	0000387	biological_process	spliceosomal snRNP assembly
l	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
l	0000398	biological_process	mRNA splicing, via spliceosome
l	0003723	molecular_function	RNA binding
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005681	cellular_component	spliceosomal complex
l	0005682	cellular_component	U5 snRNP
l	0005683	cellular_component	U7 snRNP
l	0005684	cellular_component	U2-type spliceosomal complex
l	0005685	cellular_component	U1 snRNP
l	0005686	cellular_component	U2 snRNP
l	0005687	cellular_component	U4 snRNP
l	0005689	cellular_component	U12-type spliceosomal complex
l	0005697	cellular_component	telomerase holoenzyme complex
l	0005737	cellular_component	cytoplasm
l	0005829	cellular_component	cytosol
l	0006396	biological_process	RNA processing
l	0006397	biological_process	mRNA processing
l	0006479	biological_process	protein methylation
l	0008380	biological_process	RNA splicing
l	0016604	cellular_component	nuclear body
l	0019899	molecular_function	enzyme binding
l	0030532	cellular_component	small nuclear ribonucleoprotein complex
l	0034709	cellular_component	methylosome
l	0034715	cellular_component	pICln-Sm protein complex
l	0034719	cellular_component	SMN-Sm protein complex
l	0036261	biological_process	7-methylguanosine cap hypermethylation
l	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
l	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
l	0070034	molecular_function	telomerase RNA binding
l	0071005	cellular_component	U2-type precatalytic spliceosome
l	0071007	cellular_component	U2-type catalytic step 2 spliceosome
l	0071011	cellular_component	precatalytic spliceosome
l	0071013	cellular_component	catalytic step 2 spliceosome
l	0071045	biological_process	nuclear histone mRNA catabolic process
l	0071208	molecular_function	histone pre-mRNA DCP binding
l	0071209	molecular_function	U7 snRNA binding
l	0097526	cellular_component	spliceosomal tri-snRNP complex
l	1903241	biological_process	U2-type prespliceosome assembly
l	1990904	cellular_component	ribonucleoprotein complex
m	0000244	biological_process	spliceosomal tri-snRNP complex assembly
m	0000245	biological_process	spliceosomal complex assembly
m	0000387	biological_process	spliceosomal snRNP assembly
m	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
m	0000398	biological_process	mRNA splicing, via spliceosome
m	0003723	molecular_function	RNA binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005681	cellular_component	spliceosomal complex
m	0005682	cellular_component	U5 snRNP
m	0005683	cellular_component	U7 snRNP
m	0005684	cellular_component	U2-type spliceosomal complex
m	0005685	cellular_component	U1 snRNP
m	0005686	cellular_component	U2 snRNP
m	0005687	cellular_component	U4 snRNP
m	0005689	cellular_component	U12-type spliceosomal complex
m	0005697	cellular_component	telomerase holoenzyme complex
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0006397	biological_process	mRNA processing
m	0006479	biological_process	protein methylation
m	0008380	biological_process	RNA splicing
m	0030532	cellular_component	small nuclear ribonucleoprotein complex
m	0034709	cellular_component	methylosome
m	0034719	cellular_component	SMN-Sm protein complex
m	0036261	biological_process	7-methylguanosine cap hypermethylation
m	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
m	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
m	0070034	molecular_function	telomerase RNA binding
m	0070990	molecular_function	snRNP binding
m	0071004	cellular_component	U2-type prespliceosome
m	0071005	cellular_component	U2-type precatalytic spliceosome
m	0071007	cellular_component	U2-type catalytic step 2 spliceosome
m	0071013	cellular_component	catalytic step 2 spliceosome
m	0071045	biological_process	nuclear histone mRNA catabolic process
m	0071204	cellular_component	histone pre-mRNA 3'end processing complex
m	0071208	molecular_function	histone pre-mRNA DCP binding
m	1903241	biological_process	U2-type prespliceosome assembly
m	1990446	molecular_function	U1 snRNP binding
m	1990447	molecular_function	U2 snRNP binding
m	1990904	cellular_component	ribonucleoprotein complex
n	0000243	cellular_component	commitment complex
n	0000244	biological_process	spliceosomal tri-snRNP complex assembly
n	0000245	biological_process	spliceosomal complex assembly
n	0000387	biological_process	spliceosomal snRNP assembly
n	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
n	0000398	biological_process	mRNA splicing, via spliceosome
n	0003723	molecular_function	RNA binding
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0005681	cellular_component	spliceosomal complex
n	0005682	cellular_component	U5 snRNP
n	0005684	cellular_component	U2-type spliceosomal complex
n	0005685	cellular_component	U1 snRNP
n	0005686	cellular_component	U2 snRNP
n	0005687	cellular_component	U4 snRNP
n	0005689	cellular_component	U12-type spliceosomal complex
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0006396	biological_process	RNA processing
n	0006397	biological_process	mRNA processing
n	0008380	biological_process	RNA splicing
n	0030532	cellular_component	small nuclear ribonucleoprotein complex
n	0034709	cellular_component	methylosome
n	0034715	cellular_component	pICln-Sm protein complex
n	0034719	cellular_component	SMN-Sm protein complex
n	0036261	biological_process	7-methylguanosine cap hypermethylation
n	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
n	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
n	0071005	cellular_component	U2-type precatalytic spliceosome
n	0071007	cellular_component	U2-type catalytic step 2 spliceosome
n	0071011	cellular_component	precatalytic spliceosome
n	0071013	cellular_component	catalytic step 2 spliceosome
n	0097526	cellular_component	spliceosomal tri-snRNP complex
n	1903241	biological_process	U2-type prespliceosome assembly
n	1990446	molecular_function	U1 snRNP binding
n	1990904	cellular_component	ribonucleoprotein complex
o	0000375	biological_process	RNA splicing, via transesterification reactions
o	0000387	biological_process	spliceosomal snRNP assembly
o	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
o	0000398	biological_process	mRNA splicing, via spliceosome
o	0003676	molecular_function	nucleic acid binding
o	0003723	molecular_function	RNA binding
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005681	cellular_component	spliceosomal complex
o	0005684	cellular_component	U2-type spliceosomal complex
o	0005686	cellular_component	U2 snRNP
o	0005689	cellular_component	U12-type spliceosomal complex
o	0006397	biological_process	mRNA processing
o	0008380	biological_process	RNA splicing
o	0071005	cellular_component	U2-type precatalytic spliceosome
o	0071011	cellular_component	precatalytic spliceosome
o	1903241	biological_process	U2-type prespliceosome assembly
o	1990935	molecular_function	splicing factor binding
p	0000166	molecular_function	nucleotide binding
p	0000398	biological_process	mRNA splicing, via spliceosome
p	0003676	molecular_function	nucleic acid binding
p	0003723	molecular_function	RNA binding
p	0003724	molecular_function	RNA helicase activity
p	0004386	molecular_function	helicase activity
p	0005515	molecular_function	protein binding
p	0005524	molecular_function	ATP binding
p	0005634	cellular_component	nucleus
p	0005654	cellular_component	nucleoplasm
p	0005681	cellular_component	spliceosomal complex
p	0005684	cellular_component	U2-type spliceosomal complex
p	0006397	biological_process	mRNA processing
p	0008380	biological_process	RNA splicing
p	0015030	cellular_component	Cajal body
p	0016607	cellular_component	nuclear speck
p	0016787	molecular_function	hydrolase activity
p	0016887	molecular_function	ATP hydrolysis activity
p	1903241	biological_process	U2-type prespliceosome assembly
q	0000398	biological_process	mRNA splicing, via spliceosome
q	0000724	biological_process	double-strand break repair via homologous recombination
q	0003676	molecular_function	nucleic acid binding
q	0003723	molecular_function	RNA binding
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005681	cellular_component	spliceosomal complex
q	0005684	cellular_component	U2-type spliceosomal complex
q	0005686	cellular_component	U2 snRNP
q	0005694	cellular_component	chromosome
q	0006281	biological_process	DNA repair
q	0006325	biological_process	chromatin organization
q	0006351	biological_process	DNA-templated transcription
q	0006397	biological_process	mRNA processing
q	0006974	biological_process	DNA damage response
q	0008380	biological_process	RNA splicing
q	0035861	cellular_component	site of double-strand break
q	0140463	molecular_function	chromatin-protein adaptor activity
q	0160004	molecular_function	poly-ADP-D-ribose modification-dependent protein binding
q	1903241	biological_process	U2-type prespliceosome assembly
q	1990166	biological_process	protein localization to site of double-strand break
u	0000245	biological_process	spliceosomal complex assembly
u	0000375	biological_process	RNA splicing, via transesterification reactions
u	0000387	biological_process	spliceosomal snRNP assembly
u	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
u	0000398	biological_process	mRNA splicing, via spliceosome
u	0000785	cellular_component	chromatin
u	0003723	molecular_function	RNA binding
u	0003729	molecular_function	mRNA binding
u	0005515	molecular_function	protein binding
u	0005634	cellular_component	nucleus
u	0005654	cellular_component	nucleoplasm
u	0005681	cellular_component	spliceosomal complex
u	0005684	cellular_component	U2-type spliceosomal complex
u	0005686	cellular_component	U2 snRNP
u	0005689	cellular_component	U12-type spliceosomal complex
u	0005730	cellular_component	nucleolus
u	0006338	biological_process	chromatin remodeling
u	0006397	biological_process	mRNA processing
u	0008380	biological_process	RNA splicing
u	0016607	cellular_component	nuclear speck
u	0031981	cellular_component	nuclear lumen
u	0034693	cellular_component	U11/U12 snRNP
u	0036002	molecular_function	pre-mRNA binding
u	0045943	biological_process	positive regulation of transcription by RNA polymerase I
u	0045944	biological_process	positive regulation of transcription by RNA polymerase II
u	0045945	biological_process	positive regulation of transcription by RNA polymerase III
u	0071004	cellular_component	U2-type prespliceosome
u	0071005	cellular_component	U2-type precatalytic spliceosome
u	0071013	cellular_component	catalytic step 2 spliceosome
u	1903241	biological_process	U2-type prespliceosome assembly
u	1990935	molecular_function	splicing factor binding
v	0000375	biological_process	RNA splicing, via transesterification reactions
v	0000387	biological_process	spliceosomal snRNP assembly
v	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
v	0000398	biological_process	mRNA splicing, via spliceosome
v	0003676	molecular_function	nucleic acid binding
v	0005515	molecular_function	protein binding
v	0005634	cellular_component	nucleus
v	0005654	cellular_component	nucleoplasm
v	0005681	cellular_component	spliceosomal complex
v	0005684	cellular_component	U2-type spliceosomal complex
v	0005686	cellular_component	U2 snRNP
v	0005689	cellular_component	U12-type spliceosomal complex
v	0005730	cellular_component	nucleolus
v	0006282	biological_process	regulation of DNA repair
v	0006397	biological_process	mRNA processing
v	0008380	biological_process	RNA splicing
v	0030620	molecular_function	U2 snRNA binding
v	0042177	biological_process	negative regulation of protein catabolic process
v	0043484	biological_process	regulation of RNA splicing
v	0044877	molecular_function	protein-containing complex binding
v	0045893	biological_process	positive regulation of DNA-templated transcription
v	0071005	cellular_component	U2-type precatalytic spliceosome
v	0071013	cellular_component	catalytic step 2 spliceosome
v	1903241	biological_process	U2-type prespliceosome assembly
x	0000387	biological_process	spliceosomal snRNP assembly
x	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
x	0000398	biological_process	mRNA splicing, via spliceosome
x	0003723	molecular_function	RNA binding
x	0005515	molecular_function	protein binding
x	0005634	cellular_component	nucleus
x	0005654	cellular_component	nucleoplasm
x	0005681	cellular_component	spliceosomal complex
x	0005684	cellular_component	U2-type spliceosomal complex
x	0005686	cellular_component	U2 snRNP
x	0005689	cellular_component	U12-type spliceosomal complex
x	0006282	biological_process	regulation of DNA repair
x	0006397	biological_process	mRNA processing
x	0008380	biological_process	RNA splicing
x	0043484	biological_process	regulation of RNA splicing
x	0045893	biological_process	positive regulation of DNA-templated transcription
x	0071005	cellular_component	U2-type precatalytic spliceosome
x	0071011	cellular_component	precatalytic spliceosome
x	1903241	biological_process	U2-type prespliceosome assembly
x	1990935	molecular_function	splicing factor binding
y	0000387	biological_process	spliceosomal snRNP assembly
y	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
y	0000398	biological_process	mRNA splicing, via spliceosome
y	0003677	molecular_function	DNA binding
y	0003723	molecular_function	RNA binding
y	0005515	molecular_function	protein binding
y	0005634	cellular_component	nucleus
y	0005654	cellular_component	nucleoplasm
y	0005681	cellular_component	spliceosomal complex
y	0005684	cellular_component	U2-type spliceosomal complex
y	0005686	cellular_component	U2 snRNP
y	0005689	cellular_component	U12-type spliceosomal complex
y	0006351	biological_process	DNA-templated transcription
y	0006397	biological_process	mRNA processing
y	0008270	molecular_function	zinc ion binding
y	0008380	biological_process	RNA splicing
y	0016363	cellular_component	nuclear matrix
y	0016607	cellular_component	nuclear speck
y	0045893	biological_process	positive regulation of DNA-templated transcription
y	0046872	molecular_function	metal ion binding
y	0048863	biological_process	stem cell differentiation
y	0071005	cellular_component	U2-type precatalytic spliceosome
y	0071011	cellular_component	precatalytic spliceosome
y	1903241	biological_process	U2-type prespliceosome assembly
z	0000387	biological_process	spliceosomal snRNP assembly
z	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
z	0000398	biological_process	mRNA splicing, via spliceosome
z	0003676	molecular_function	nucleic acid binding
z	0003723	molecular_function	RNA binding
z	0003729	molecular_function	mRNA binding
z	0005515	molecular_function	protein binding
z	0005634	cellular_component	nucleus
z	0005654	cellular_component	nucleoplasm
z	0005681	cellular_component	spliceosomal complex
z	0005684	cellular_component	U2-type spliceosomal complex
z	0005689	cellular_component	U12-type spliceosomal complex
z	0006397	biological_process	mRNA processing
z	0008380	biological_process	RNA splicing
z	1903241	biological_process	U2-type prespliceosome assembly

Functional Information from PROSITE/UniProt

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADRmF

Chain	Residue	Details
p	VAL527-PHE535

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FVCSATH

Chain	Residue	Details
v	PHE287-HIS293

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	77
Details	Region: {"description":"Interaction with SF3B1 and SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Region: {"description":"Interaction with SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28541300","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IFE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SYB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Interaction with SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Site: {"description":"Interaction with RNA","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Symmetric dimethylarginine; by PRMT9; alternate","evidences":[{"source":"PubMed","id":"25737013","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	37
Details	Region: {"description":"Interaction with PHF5A, SF3B1 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	56
Details	Region: {"description":"Interaction with SF3B1 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	21
Details	Region: {"description":"Interaction with SF3B1","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	23
Details	Region: {"description":"Interaction with SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	5
Details	Site: {"description":"Interaction with SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Site: {"description":"Interaction with SF3B1","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	39
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	34
Details	Repeat: {"description":"HEAT 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	37
Details	Repeat: {"description":"HEAT 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	34
Details	Repeat: {"description":"HEAT 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	38
Details	Repeat: {"description":"HEAT 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	38
Details	Repeat: {"description":"HEAT 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	38
Details	Repeat: {"description":"HEAT 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	38
Details	Repeat: {"description":"HEAT 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	38
Details	Repeat: {"description":"HEAT 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	38
Details	Repeat: {"description":"HEAT 10"}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	38
Details	Repeat: {"description":"HEAT 11"}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	39
Details	Region: {"description":"Interaction with SF3B14"}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	4
Details	Region: {"description":"Interaction with PHF5A","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	56
Details	Region: {"description":"Interaction with SF3B3 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	1
Details	Site: {"description":"Interaction with PHF5A","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	178
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	28
Details	Motif: {"description":"Q motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	3
Details	Motif: {"description":"DEAD box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	21
Details	Repeat: {"description":"LRR 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	21
Details	Repeat: {"description":"LRR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	21
Details	Repeat: {"description":"LRR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	21
Details	Repeat: {"description":"LRR 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	38
Details	Domain: {"description":"LRRCT"}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	164
Details	Domain: {"description":"RRM 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI47
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI48
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI49
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI50
Number of Residues	42
Details	Repeat: {"description":"SURP motif 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI51
Number of Residues	1
Details	Site: {"description":"Critical for binding to SF3A3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI52
Number of Residues	31
Details	Zinc finger: {"description":"Matrin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00130","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI53
Number of Residues	4
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"21349847","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI54
Number of Residues	11
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI55
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"OCT-2004","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI56
Number of Residues	376
Details	Domain: {"description":"Sm","evidences":[{"source":"PROSITE-ProRule","id":"PRU01346","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI57
Number of Residues	79
Details	Region: {"description":"Sufficient for interaction with CLNS1A","evidences":[{"source":"PubMed","id":"11747828","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI58
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI59
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI60
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8BGC0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---