6Y5A
Serotonin-bound 5-HT3A receptor in Salipro
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0045211 | cellular_component | postsynaptic membrane |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0045211 | cellular_component | postsynaptic membrane |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0045211 | cellular_component | postsynaptic membrane |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0045211 | cellular_component | postsynaptic membrane |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0045211 | cellular_component | postsynaptic membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue SRO A 501 |
| Chain | Residue |
| A | TRP63 |
| A | TYR64 |
| A | ARG65 |
| A | TYR126 |
| A | LYS127 |
| E | SER155 |
| E | TRP156 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue SRO C 501 |
| Chain | Residue |
| C | TRP63 |
| C | TYR64 |
| C | ARG65 |
| C | TYR126 |
| C | LYS127 |
| B | SER155 |
| B | TRP156 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue SRO D 501 |
| Chain | Residue |
| C | SER155 |
| C | TRP156 |
| D | TRP63 |
| D | TYR64 |
| D | ARG65 |
| D | TYR126 |
| D | LYS127 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue SRO B 501 |
| Chain | Residue |
| A | SER155 |
| A | TRP156 |
| A | TYR207 |
| B | TRP63 |
| B | TYR64 |
| B | ARG65 |
| B | TYR126 |
| B | LYS127 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue SRO E 501 |
| Chain | Residue |
| D | SER155 |
| D | TRP156 |
| E | TRP63 |
| E | TYR64 |
| E | ARG65 |
| E | TYR126 |
| E | LYS127 |
Functional Information from PROSITE/UniProt
| site_id | PS00236 |
| Number of Residues | 15 |
| Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CsLdIynFPfDvqnC |
| Chain | Residue | Details |
| A | CYS135-CYS149 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 130 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"25119048","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 90 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 55 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"25119048","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 90 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 95 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 15 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
