6Y5A
Serotonin-bound 5-HT3A receptor in Salipro
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004888 | molecular_function | transmembrane signaling receptor activity |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
A | 0016020 | cellular_component | membrane |
A | 0034220 | biological_process | monoatomic ion transmembrane transport |
A | 0045211 | cellular_component | postsynaptic membrane |
B | 0004888 | molecular_function | transmembrane signaling receptor activity |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
B | 0016020 | cellular_component | membrane |
B | 0034220 | biological_process | monoatomic ion transmembrane transport |
B | 0045211 | cellular_component | postsynaptic membrane |
C | 0004888 | molecular_function | transmembrane signaling receptor activity |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
C | 0016020 | cellular_component | membrane |
C | 0034220 | biological_process | monoatomic ion transmembrane transport |
C | 0045211 | cellular_component | postsynaptic membrane |
D | 0004888 | molecular_function | transmembrane signaling receptor activity |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
D | 0016020 | cellular_component | membrane |
D | 0034220 | biological_process | monoatomic ion transmembrane transport |
D | 0045211 | cellular_component | postsynaptic membrane |
E | 0004888 | molecular_function | transmembrane signaling receptor activity |
E | 0005216 | molecular_function | monoatomic ion channel activity |
E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
E | 0006811 | biological_process | monoatomic ion transport |
E | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
E | 0016020 | cellular_component | membrane |
E | 0034220 | biological_process | monoatomic ion transmembrane transport |
E | 0045211 | cellular_component | postsynaptic membrane |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue SRO A 501 |
Chain | Residue |
A | TRP63 |
A | TYR64 |
A | ARG65 |
A | TYR126 |
A | LYS127 |
E | SER155 |
E | TRP156 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue SRO C 501 |
Chain | Residue |
C | TRP63 |
C | TYR64 |
C | ARG65 |
C | TYR126 |
C | LYS127 |
B | SER155 |
B | TRP156 |
site_id | AC3 |
Number of Residues | 7 |
Details | binding site for residue SRO D 501 |
Chain | Residue |
C | SER155 |
C | TRP156 |
D | TRP63 |
D | TYR64 |
D | ARG65 |
D | TYR126 |
D | LYS127 |
site_id | AC4 |
Number of Residues | 8 |
Details | binding site for residue SRO B 501 |
Chain | Residue |
A | SER155 |
A | TRP156 |
A | TYR207 |
B | TRP63 |
B | TYR64 |
B | ARG65 |
B | TYR126 |
B | LYS127 |
site_id | AC5 |
Number of Residues | 7 |
Details | binding site for residue SRO E 501 |
Chain | Residue |
D | SER155 |
D | TRP156 |
E | TRP63 |
E | TYR64 |
E | ARG65 |
E | TYR126 |
E | LYS127 |
Functional Information from PROSITE/UniProt
site_id | PS00236 |
Number of Residues | 15 |
Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CsLdIynFPfDvqnC |
Chain | Residue | Details |
A | CYS135-CYS149 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 130 |
Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
Chain | Residue | Details |
A | LEU221-ASP247 | |
C | LEU221-ASP247 | |
D | LEU221-ASP247 | |
B | LEU221-ASP247 | |
E | LEU221-ASP247 |
site_id | SWS_FT_FI2 |
Number of Residues | 715 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:25119048 |
Chain | Residue | Details |
A | SER248-VAL252 | |
E | GLU300-ARG439 | |
A | GLU300-ARG439 | |
C | SER248-VAL252 | |
C | GLU300-ARG439 | |
D | SER248-VAL252 | |
D | GLU300-ARG439 | |
B | SER248-VAL252 | |
B | GLU300-ARG439 | |
E | SER248-VAL252 |
site_id | SWS_FT_FI3 |
Number of Residues | 90 |
Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
Chain | Residue | Details |
A | SER253-ASP271 | |
C | SER253-ASP271 | |
D | SER253-ASP271 | |
B | SER253-ASP271 | |
E | SER253-ASP271 |
site_id | SWS_FT_FI4 |
Number of Residues | 55 |
Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:25119048 |
Chain | Residue | Details |
A | THR272-PRO281 | |
E | HIS460-SER462 | |
A | HIS460-SER462 | |
C | THR272-PRO281 | |
C | HIS460-SER462 | |
D | THR272-PRO281 | |
D | HIS460-SER462 | |
B | THR272-PRO281 | |
B | HIS460-SER462 | |
E | THR272-PRO281 |
site_id | SWS_FT_FI5 |
Number of Residues | 90 |
Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
Chain | Residue | Details |
A | PRO281-ALA299 | |
C | PRO281-ALA299 | |
D | PRO281-ALA299 | |
B | PRO281-ALA299 | |
E | PRO281-ALA299 |
site_id | SWS_FT_FI6 |
Number of Residues | 95 |
Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
Chain | Residue | Details |
A | ILE440-TRP459 | |
C | ILE440-TRP459 | |
D | ILE440-TRP459 | |
B | ILE440-TRP459 | |
E | ILE440-TRP459 |
site_id | SWS_FT_FI7 |
Number of Residues | 15 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | VAL83 | |
B | VAL83 | |
B | CYS149 | |
B | ILE165 | |
E | VAL83 | |
E | CYS149 | |
E | ILE165 | |
A | CYS149 | |
A | ILE165 | |
C | VAL83 | |
C | CYS149 | |
C | ILE165 | |
D | VAL83 | |
D | CYS149 | |
D | ILE165 |