6Y50
5'domain of human 17S U2 snRNP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| 8 | 0000398 | biological_process | mRNA splicing, via spliceosome |
| 8 | 0003723 | molecular_function | RNA binding |
| 8 | 0005515 | molecular_function | protein binding |
| 8 | 0005634 | cellular_component | nucleus |
| 8 | 0005654 | cellular_component | nucleoplasm |
| 8 | 0005681 | cellular_component | spliceosomal complex |
| 8 | 0005684 | cellular_component | U2-type spliceosomal complex |
| 8 | 0005686 | cellular_component | U2 snRNP |
| 8 | 0005689 | cellular_component | U12-type spliceosomal complex |
| 8 | 0006397 | biological_process | mRNA processing |
| 8 | 0008380 | biological_process | RNA splicing |
| 8 | 0016607 | cellular_component | nuclear speck |
| 8 | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| 8 | 0071011 | cellular_component | precatalytic spliceosome |
| 8 | 0071013 | cellular_component | catalytic step 2 spliceosome |
| 8 | 1903241 | biological_process | U2-type prespliceosome assembly |
| 9 | 0000375 | biological_process | RNA splicing, via transesterification reactions |
| 9 | 0000389 | biological_process | mRNA 3'-splice site recognition |
| 9 | 0000398 | biological_process | mRNA splicing, via spliceosome |
| 9 | 0003676 | molecular_function | nucleic acid binding |
| 9 | 0003723 | molecular_function | RNA binding |
| 9 | 0005515 | molecular_function | protein binding |
| 9 | 0005634 | cellular_component | nucleus |
| 9 | 0005654 | cellular_component | nucleoplasm |
| 9 | 0005681 | cellular_component | spliceosomal complex |
| 9 | 0005684 | cellular_component | U2-type spliceosomal complex |
| 9 | 0005686 | cellular_component | U2 snRNP |
| 9 | 0006397 | biological_process | mRNA processing |
| 9 | 0008270 | molecular_function | zinc ion binding |
| 9 | 0008380 | biological_process | RNA splicing |
| 9 | 0016607 | cellular_component | nuclear speck |
| 9 | 0046872 | molecular_function | metal ion binding |
| 9 | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| 9 | 0071013 | cellular_component | catalytic step 2 spliceosome |
| 9 | 1903241 | biological_process | U2-type prespliceosome assembly |
| p | 0000398 | biological_process | mRNA splicing, via spliceosome |
| p | 0001650 | cellular_component | fibrillar center |
| p | 0003676 | molecular_function | nucleic acid binding |
| p | 0003723 | molecular_function | RNA binding |
| p | 0003724 | molecular_function | RNA helicase activity |
| p | 0004386 | molecular_function | helicase activity |
| p | 0005515 | molecular_function | protein binding |
| p | 0005524 | molecular_function | ATP binding |
| p | 0005634 | cellular_component | nucleus |
| p | 0005654 | cellular_component | nucleoplasm |
| p | 0005681 | cellular_component | spliceosomal complex |
| p | 0005684 | cellular_component | U2-type spliceosomal complex |
| p | 0005686 | cellular_component | U2 snRNP |
| p | 0006397 | biological_process | mRNA processing |
| p | 0008380 | biological_process | RNA splicing |
| p | 0015030 | cellular_component | Cajal body |
| p | 0016607 | cellular_component | nuclear speck |
| p | 0016787 | molecular_function | hydrolase activity |
| p | 0016887 | molecular_function | ATP hydrolysis activity |
| p | 1903241 | biological_process | U2-type prespliceosome assembly |
| q | 0000398 | biological_process | mRNA splicing, via spliceosome |
| q | 0000724 | biological_process | double-strand break repair via homologous recombination |
| q | 0003676 | molecular_function | nucleic acid binding |
| q | 0003723 | molecular_function | RNA binding |
| q | 0005515 | molecular_function | protein binding |
| q | 0005634 | cellular_component | nucleus |
| q | 0005654 | cellular_component | nucleoplasm |
| q | 0005681 | cellular_component | spliceosomal complex |
| q | 0005684 | cellular_component | U2-type spliceosomal complex |
| q | 0005686 | cellular_component | U2 snRNP |
| q | 0005694 | cellular_component | chromosome |
| q | 0006281 | biological_process | DNA repair |
| q | 0006325 | biological_process | chromatin organization |
| q | 0006397 | biological_process | mRNA processing |
| q | 0008380 | biological_process | RNA splicing |
| q | 0035861 | cellular_component | site of double-strand break |
| q | 0140463 | molecular_function | chromatin-protein adaptor activity |
| q | 0160004 | molecular_function | poly-ADP-D-ribose modification-dependent protein binding |
| q | 1903241 | biological_process | U2-type prespliceosome assembly |
| q | 1990166 | biological_process | protein localization to site of double-strand break |
| u | 0000245 | biological_process | spliceosomal complex assembly |
| u | 0000375 | biological_process | RNA splicing, via transesterification reactions |
| u | 0000398 | biological_process | mRNA splicing, via spliceosome |
| u | 0003723 | molecular_function | RNA binding |
| u | 0003729 | molecular_function | mRNA binding |
| u | 0005515 | molecular_function | protein binding |
| u | 0005634 | cellular_component | nucleus |
| u | 0005654 | cellular_component | nucleoplasm |
| u | 0005681 | cellular_component | spliceosomal complex |
| u | 0005684 | cellular_component | U2-type spliceosomal complex |
| u | 0005686 | cellular_component | U2 snRNP |
| u | 0005689 | cellular_component | U12-type spliceosomal complex |
| u | 0005730 | cellular_component | nucleolus |
| u | 0006338 | biological_process | chromatin remodeling |
| u | 0006397 | biological_process | mRNA processing |
| u | 0008380 | biological_process | RNA splicing |
| u | 0016607 | cellular_component | nuclear speck |
| u | 0034693 | cellular_component | U11/U12 snRNP |
| u | 0045943 | biological_process | positive regulation of transcription by RNA polymerase I |
| u | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| u | 0045945 | biological_process | positive regulation of transcription by RNA polymerase III |
| u | 0071004 | cellular_component | U2-type prespliceosome |
| u | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| u | 0071013 | cellular_component | catalytic step 2 spliceosome |
| u | 0110016 | cellular_component | B-WICH complex |
| u | 1903241 | biological_process | U2-type prespliceosome assembly |
| u | 1990935 | molecular_function | splicing factor binding |
| v | 0000124 | cellular_component | SAGA complex |
| v | 0000375 | biological_process | RNA splicing, via transesterification reactions |
| v | 0000398 | biological_process | mRNA splicing, via spliceosome |
| v | 0003676 | molecular_function | nucleic acid binding |
| v | 0005515 | molecular_function | protein binding |
| v | 0005634 | cellular_component | nucleus |
| v | 0005654 | cellular_component | nucleoplasm |
| v | 0005681 | cellular_component | spliceosomal complex |
| v | 0005684 | cellular_component | U2-type spliceosomal complex |
| v | 0005686 | cellular_component | U2 snRNP |
| v | 0005689 | cellular_component | U12-type spliceosomal complex |
| v | 0005730 | cellular_component | nucleolus |
| v | 0006282 | biological_process | regulation of DNA repair |
| v | 0006397 | biological_process | mRNA processing |
| v | 0008380 | biological_process | RNA splicing |
| v | 0030620 | molecular_function | U2 snRNA binding |
| v | 0042177 | biological_process | negative regulation of protein catabolic process |
| v | 0043484 | biological_process | regulation of RNA splicing |
| v | 0044877 | molecular_function | protein-containing complex binding |
| v | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| v | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| v | 0071013 | cellular_component | catalytic step 2 spliceosome |
| v | 1903241 | biological_process | U2-type prespliceosome assembly |
| x | 0000124 | cellular_component | SAGA complex |
| x | 0000398 | biological_process | mRNA splicing, via spliceosome |
| x | 0003723 | molecular_function | RNA binding |
| x | 0005515 | molecular_function | protein binding |
| x | 0005634 | cellular_component | nucleus |
| x | 0005654 | cellular_component | nucleoplasm |
| x | 0005681 | cellular_component | spliceosomal complex |
| x | 0005684 | cellular_component | U2-type spliceosomal complex |
| x | 0005686 | cellular_component | U2 snRNP |
| x | 0005689 | cellular_component | U12-type spliceosomal complex |
| x | 0006282 | biological_process | regulation of DNA repair |
| x | 0006397 | biological_process | mRNA processing |
| x | 0008380 | biological_process | RNA splicing |
| x | 0043484 | biological_process | regulation of RNA splicing |
| x | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| x | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| x | 0071011 | cellular_component | precatalytic spliceosome |
| x | 1903241 | biological_process | U2-type prespliceosome assembly |
| x | 1990935 | molecular_function | splicing factor binding |
| y | 0000398 | biological_process | mRNA splicing, via spliceosome |
| y | 0003677 | molecular_function | DNA binding |
| y | 0003723 | molecular_function | RNA binding |
| y | 0005515 | molecular_function | protein binding |
| y | 0005634 | cellular_component | nucleus |
| y | 0005654 | cellular_component | nucleoplasm |
| y | 0005681 | cellular_component | spliceosomal complex |
| y | 0005684 | cellular_component | U2-type spliceosomal complex |
| y | 0005686 | cellular_component | U2 snRNP |
| y | 0005689 | cellular_component | U12-type spliceosomal complex |
| y | 0006397 | biological_process | mRNA processing |
| y | 0008270 | molecular_function | zinc ion binding |
| y | 0008380 | biological_process | RNA splicing |
| y | 0016363 | cellular_component | nuclear matrix |
| y | 0016607 | cellular_component | nuclear speck |
| y | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| y | 0046872 | molecular_function | metal ion binding |
| y | 0048863 | biological_process | stem cell differentiation |
| y | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| y | 0071011 | cellular_component | precatalytic spliceosome |
| y | 1903241 | biological_process | U2-type prespliceosome assembly |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN y 201 |
| Chain | Residue |
| y | CYS30 |
| y | ILE32 |
| y | CYS33 |
| y | ASP34 |
| y | CYS72 |
| y | CYS75 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN y 202 |
| Chain | Residue |
| y | CYS61 |
| y | CYS23 |
| y | CYS26 |
| y | ILE60 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN y 203 |
| Chain | Residue |
| y | CYS11 |
| y | CYS49 |
| y | CYS85 |
| y | LYS87 |
Functional Information from PROSITE/UniProt
| site_id | PS00039 |
| Number of Residues | 9 |
| Details | DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADRmF |
| Chain | Residue | Details |
| p | VAL527-PHE535 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FVCSATH |
| Chain | Residue | Details |
| v | PHE287-HIS293 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541 |
| Chain | Residue | Details |
| p | ALA416 | |
| y | CYS72 | |
| y | CYS75 | |
| y | CYS85 | |
| u | TYR587 | |
| u | CYS1035 | |
| u | TYR1049 | |
| u | LEU1141 | |
| y | CYS46 | |
| y | CYS49 | |
| y | CYS58 | |
| y | CYS61 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q62780 |
| Chain | Residue | Details |
| p | SER199 | |
| v | LYS1171 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| p | LYS263 | |
| p | LYS776 | |
| u | GLU1205 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| p | TYR294 | |
| q | SER407 | |
| u | THR426 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| p | SER295 | |
| p | SER296 | |
| 9 | SER369 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| p | SER346 | |
| p | SER928 | |
| u | LYS562 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| p | SER804 | |
| q | SER453 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q569Z5 |
| Chain | Residue | Details |
| p | LYS903 | |
| q | SER494 | |
| q | SER521 | |
| q | SER529 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | LIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805 |
| Chain | Residue | Details |
| p | GLY2 | |
| q | SER607 | |
| 8 | SER436 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| p | LYS186 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 5 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| q | SER557 | |
| p | LYS325 | |
| p | LYS779 | |
| p | LYS907 | |
| p | LYS915 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| q | SER579 | |
| 8 | LYS280 | |
| 8 | LYS492 | |
| 8 | LYS543 | |
| 8 | LYS770 | |
| 8 | LYS790 | |
| 8 | LYS843 | |
| 8 | LYS857 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| q | SER597 | |
| q | SER600 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| q | SER616 | |
| q | SER676 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| q | SER624 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| q | THR633 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| q | SER642 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| q | SER702 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| q | SER713 | |
| q | SER714 | |
| u | THR278 | |
| u | THR303 | |
| u | THR313 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| q | SER721 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:35597237 |
| Chain | Residue | Details |
| q | SER748 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| q | LYS429 | |
| q | LYS430 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| u | THR296 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983 |
| Chain | Residue | Details |
| u | THR299 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| u | SER322 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| u | THR326 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| u | THR328 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| u | SER332 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| u | THR341 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| u | SER344 |
| site_id | SWS_FT_FI31 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| u | SER349 |
| site_id | SWS_FT_FI32 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| u | THR350 | |
| u | THR436 |
| site_id | SWS_FT_FI33 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| u | THR354 |
| site_id | SWS_FT_FI34 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| u | SER400 |
| site_id | SWS_FT_FI35 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by DYRK1A => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| u | THR434 |
| site_id | SWS_FT_FI36 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| u | SER488 |
| site_id | SWS_FT_FI37 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| u | LYS214 |
| site_id | SWS_FT_FI38 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| u | LYS430 |
| site_id | SWS_FT_FI39 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| u | LYS413 |
