6Y50
5'domain of human 17S U2 snRNP
Functional Information from GO Data
Chain | GOid | namespace | contents |
8 | 0000398 | biological_process | mRNA splicing, via spliceosome |
8 | 0003723 | molecular_function | RNA binding |
8 | 0005515 | molecular_function | protein binding |
8 | 0005634 | cellular_component | nucleus |
8 | 0005654 | cellular_component | nucleoplasm |
8 | 0005681 | cellular_component | spliceosomal complex |
8 | 0005684 | cellular_component | U2-type spliceosomal complex |
8 | 0005686 | cellular_component | U2 snRNP |
8 | 0005689 | cellular_component | U12-type spliceosomal complex |
8 | 0006397 | biological_process | mRNA processing |
8 | 0008380 | biological_process | RNA splicing |
8 | 0016607 | cellular_component | nuclear speck |
8 | 0071005 | cellular_component | U2-type precatalytic spliceosome |
8 | 0071011 | cellular_component | precatalytic spliceosome |
8 | 0071013 | cellular_component | catalytic step 2 spliceosome |
8 | 1903241 | biological_process | U2-type prespliceosome assembly |
9 | 0000375 | biological_process | RNA splicing, via transesterification reactions |
9 | 0000389 | biological_process | mRNA 3'-splice site recognition |
9 | 0000398 | biological_process | mRNA splicing, via spliceosome |
9 | 0003676 | molecular_function | nucleic acid binding |
9 | 0003723 | molecular_function | RNA binding |
9 | 0005515 | molecular_function | protein binding |
9 | 0005634 | cellular_component | nucleus |
9 | 0005654 | cellular_component | nucleoplasm |
9 | 0005681 | cellular_component | spliceosomal complex |
9 | 0005684 | cellular_component | U2-type spliceosomal complex |
9 | 0005686 | cellular_component | U2 snRNP |
9 | 0006397 | biological_process | mRNA processing |
9 | 0008270 | molecular_function | zinc ion binding |
9 | 0008380 | biological_process | RNA splicing |
9 | 0016607 | cellular_component | nuclear speck |
9 | 0046872 | molecular_function | metal ion binding |
9 | 0071005 | cellular_component | U2-type precatalytic spliceosome |
9 | 0071013 | cellular_component | catalytic step 2 spliceosome |
9 | 1903241 | biological_process | U2-type prespliceosome assembly |
p | 0000398 | biological_process | mRNA splicing, via spliceosome |
p | 0001650 | cellular_component | fibrillar center |
p | 0003676 | molecular_function | nucleic acid binding |
p | 0003723 | molecular_function | RNA binding |
p | 0003724 | molecular_function | RNA helicase activity |
p | 0004386 | molecular_function | helicase activity |
p | 0005515 | molecular_function | protein binding |
p | 0005524 | molecular_function | ATP binding |
p | 0005634 | cellular_component | nucleus |
p | 0005654 | cellular_component | nucleoplasm |
p | 0005681 | cellular_component | spliceosomal complex |
p | 0005684 | cellular_component | U2-type spliceosomal complex |
p | 0005686 | cellular_component | U2 snRNP |
p | 0006397 | biological_process | mRNA processing |
p | 0008380 | biological_process | RNA splicing |
p | 0015030 | cellular_component | Cajal body |
p | 0016607 | cellular_component | nuclear speck |
p | 0016787 | molecular_function | hydrolase activity |
p | 0016887 | molecular_function | ATP hydrolysis activity |
p | 1903241 | biological_process | U2-type prespliceosome assembly |
q | 0000398 | biological_process | mRNA splicing, via spliceosome |
q | 0000724 | biological_process | double-strand break repair via homologous recombination |
q | 0003676 | molecular_function | nucleic acid binding |
q | 0003723 | molecular_function | RNA binding |
q | 0005515 | molecular_function | protein binding |
q | 0005634 | cellular_component | nucleus |
q | 0005654 | cellular_component | nucleoplasm |
q | 0005681 | cellular_component | spliceosomal complex |
q | 0005684 | cellular_component | U2-type spliceosomal complex |
q | 0005686 | cellular_component | U2 snRNP |
q | 0005694 | cellular_component | chromosome |
q | 0006281 | biological_process | DNA repair |
q | 0006325 | biological_process | chromatin organization |
q | 0006397 | biological_process | mRNA processing |
q | 0008380 | biological_process | RNA splicing |
q | 0035861 | cellular_component | site of double-strand break |
q | 0140463 | molecular_function | chromatin-protein adaptor activity |
q | 0160004 | molecular_function | poly-ADP-D-ribose modification-dependent protein binding |
q | 1903241 | biological_process | U2-type prespliceosome assembly |
q | 1990166 | biological_process | protein localization to site of double-strand break |
u | 0000245 | biological_process | spliceosomal complex assembly |
u | 0000375 | biological_process | RNA splicing, via transesterification reactions |
u | 0000398 | biological_process | mRNA splicing, via spliceosome |
u | 0003723 | molecular_function | RNA binding |
u | 0003729 | molecular_function | mRNA binding |
u | 0005515 | molecular_function | protein binding |
u | 0005634 | cellular_component | nucleus |
u | 0005654 | cellular_component | nucleoplasm |
u | 0005681 | cellular_component | spliceosomal complex |
u | 0005684 | cellular_component | U2-type spliceosomal complex |
u | 0005686 | cellular_component | U2 snRNP |
u | 0005689 | cellular_component | U12-type spliceosomal complex |
u | 0005730 | cellular_component | nucleolus |
u | 0006338 | biological_process | chromatin remodeling |
u | 0006397 | biological_process | mRNA processing |
u | 0008380 | biological_process | RNA splicing |
u | 0016607 | cellular_component | nuclear speck |
u | 0034693 | cellular_component | U11/U12 snRNP |
u | 0045943 | biological_process | positive regulation of transcription by RNA polymerase I |
u | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
u | 0045945 | biological_process | positive regulation of transcription by RNA polymerase III |
u | 0071004 | cellular_component | U2-type prespliceosome |
u | 0071005 | cellular_component | U2-type precatalytic spliceosome |
u | 0071013 | cellular_component | catalytic step 2 spliceosome |
u | 0110016 | cellular_component | B-WICH complex |
u | 1903241 | biological_process | U2-type prespliceosome assembly |
u | 1990935 | molecular_function | splicing factor binding |
v | 0000124 | cellular_component | SAGA complex |
v | 0000375 | biological_process | RNA splicing, via transesterification reactions |
v | 0000398 | biological_process | mRNA splicing, via spliceosome |
v | 0003676 | molecular_function | nucleic acid binding |
v | 0005515 | molecular_function | protein binding |
v | 0005634 | cellular_component | nucleus |
v | 0005654 | cellular_component | nucleoplasm |
v | 0005681 | cellular_component | spliceosomal complex |
v | 0005684 | cellular_component | U2-type spliceosomal complex |
v | 0005686 | cellular_component | U2 snRNP |
v | 0005689 | cellular_component | U12-type spliceosomal complex |
v | 0005730 | cellular_component | nucleolus |
v | 0006282 | biological_process | regulation of DNA repair |
v | 0006397 | biological_process | mRNA processing |
v | 0008380 | biological_process | RNA splicing |
v | 0030620 | molecular_function | U2 snRNA binding |
v | 0042177 | biological_process | negative regulation of protein catabolic process |
v | 0043484 | biological_process | regulation of RNA splicing |
v | 0044877 | molecular_function | protein-containing complex binding |
v | 0045893 | biological_process | positive regulation of DNA-templated transcription |
v | 0071005 | cellular_component | U2-type precatalytic spliceosome |
v | 0071013 | cellular_component | catalytic step 2 spliceosome |
v | 1903241 | biological_process | U2-type prespliceosome assembly |
x | 0000124 | cellular_component | SAGA complex |
x | 0000398 | biological_process | mRNA splicing, via spliceosome |
x | 0003723 | molecular_function | RNA binding |
x | 0005515 | molecular_function | protein binding |
x | 0005634 | cellular_component | nucleus |
x | 0005654 | cellular_component | nucleoplasm |
x | 0005681 | cellular_component | spliceosomal complex |
x | 0005684 | cellular_component | U2-type spliceosomal complex |
x | 0005686 | cellular_component | U2 snRNP |
x | 0005689 | cellular_component | U12-type spliceosomal complex |
x | 0006282 | biological_process | regulation of DNA repair |
x | 0006397 | biological_process | mRNA processing |
x | 0008380 | biological_process | RNA splicing |
x | 0043484 | biological_process | regulation of RNA splicing |
x | 0045893 | biological_process | positive regulation of DNA-templated transcription |
x | 0071005 | cellular_component | U2-type precatalytic spliceosome |
x | 0071011 | cellular_component | precatalytic spliceosome |
x | 1903241 | biological_process | U2-type prespliceosome assembly |
x | 1990935 | molecular_function | splicing factor binding |
y | 0000398 | biological_process | mRNA splicing, via spliceosome |
y | 0003677 | molecular_function | DNA binding |
y | 0003723 | molecular_function | RNA binding |
y | 0005515 | molecular_function | protein binding |
y | 0005634 | cellular_component | nucleus |
y | 0005654 | cellular_component | nucleoplasm |
y | 0005681 | cellular_component | spliceosomal complex |
y | 0005684 | cellular_component | U2-type spliceosomal complex |
y | 0005686 | cellular_component | U2 snRNP |
y | 0005689 | cellular_component | U12-type spliceosomal complex |
y | 0006397 | biological_process | mRNA processing |
y | 0008270 | molecular_function | zinc ion binding |
y | 0008380 | biological_process | RNA splicing |
y | 0016363 | cellular_component | nuclear matrix |
y | 0016607 | cellular_component | nuclear speck |
y | 0045893 | biological_process | positive regulation of DNA-templated transcription |
y | 0046872 | molecular_function | metal ion binding |
y | 0048863 | biological_process | stem cell differentiation |
y | 0071005 | cellular_component | U2-type precatalytic spliceosome |
y | 0071011 | cellular_component | precatalytic spliceosome |
y | 1903241 | biological_process | U2-type prespliceosome assembly |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | binding site for residue ZN y 201 |
Chain | Residue |
y | CYS30 |
y | ILE32 |
y | CYS33 |
y | ASP34 |
y | CYS72 |
y | CYS75 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue ZN y 202 |
Chain | Residue |
y | CYS61 |
y | CYS23 |
y | CYS26 |
y | ILE60 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue ZN y 203 |
Chain | Residue |
y | CYS11 |
y | CYS49 |
y | CYS85 |
y | LYS87 |
Functional Information from PROSITE/UniProt
site_id | PS00039 |
Number of Residues | 9 |
Details | DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADRmF |
Chain | Residue | Details |
p | VAL527-PHE535 |
site_id | PS00290 |
Number of Residues | 7 |
Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FVCSATH |
Chain | Residue | Details |
v | PHE287-HIS293 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541 |
Chain | Residue | Details |
p | ALA416 | |
y | CYS72 | |
y | CYS75 | |
y | CYS85 | |
u | TYR587 | |
u | CYS1035 | |
u | TYR1049 | |
u | LEU1141 | |
y | CYS46 | |
y | CYS49 | |
y | CYS58 | |
y | CYS61 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q62780 |
Chain | Residue | Details |
p | SER199 | |
v | LYS1171 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
p | LYS263 | |
p | LYS776 | |
u | GLU1205 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332 |
Chain | Residue | Details |
p | TYR294 | |
q | SER407 | |
u | THR426 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332 |
Chain | Residue | Details |
p | SER295 | |
p | SER296 | |
9 | SER369 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
p | SER346 | |
p | SER928 | |
u | LYS562 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
p | SER804 | |
q | SER453 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q569Z5 |
Chain | Residue | Details |
p | LYS903 | |
q | SER494 | |
q | SER521 | |
q | SER529 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | LIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805 |
Chain | Residue | Details |
p | GLY2 | |
q | SER607 | |
8 | SER436 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
p | LYS186 |
site_id | SWS_FT_FI11 |
Number of Residues | 5 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
q | SER557 | |
p | LYS325 | |
p | LYS779 | |
p | LYS907 | |
p | LYS915 |
site_id | SWS_FT_FI12 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
q | SER579 | |
8 | LYS280 | |
8 | LYS492 | |
8 | LYS543 | |
8 | LYS770 | |
8 | LYS790 | |
8 | LYS843 | |
8 | LYS857 |
site_id | SWS_FT_FI13 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:21406692 |
Chain | Residue | Details |
q | SER597 | |
q | SER600 |
site_id | SWS_FT_FI14 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
q | SER616 | |
q | SER676 |
site_id | SWS_FT_FI15 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
q | SER624 |
site_id | SWS_FT_FI16 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231 |
Chain | Residue | Details |
q | THR633 |
site_id | SWS_FT_FI17 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
q | SER642 |
site_id | SWS_FT_FI18 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
q | SER702 |
site_id | SWS_FT_FI19 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
q | SER713 | |
q | SER714 | |
u | THR278 | |
u | THR303 | |
u | THR313 |
site_id | SWS_FT_FI20 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
q | SER721 |
site_id | SWS_FT_FI21 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:35597237 |
Chain | Residue | Details |
q | SER748 |
site_id | SWS_FT_FI22 |
Number of Residues | 3 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
q | LYS429 | |
q | LYS430 |
site_id | SWS_FT_FI23 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
u | THR296 |
site_id | SWS_FT_FI24 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983 |
Chain | Residue | Details |
u | THR299 |
site_id | SWS_FT_FI25 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
u | SER322 |
site_id | SWS_FT_FI26 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
u | THR326 |
site_id | SWS_FT_FI27 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231 |
Chain | Residue | Details |
u | THR328 |
site_id | SWS_FT_FI28 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
u | SER332 |
site_id | SWS_FT_FI29 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692 |
Chain | Residue | Details |
u | THR341 |
site_id | SWS_FT_FI30 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692 |
Chain | Residue | Details |
u | SER344 |
site_id | SWS_FT_FI31 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692 |
Chain | Residue | Details |
u | SER349 |
site_id | SWS_FT_FI32 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
u | THR350 | |
u | THR436 |
site_id | SWS_FT_FI33 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
u | THR354 |
site_id | SWS_FT_FI34 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
u | SER400 |
site_id | SWS_FT_FI35 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine; by DYRK1A => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
u | THR434 |
site_id | SWS_FT_FI36 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
u | SER488 |
site_id | SWS_FT_FI37 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
u | LYS214 |
site_id | SWS_FT_FI38 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
u | LYS430 |
site_id | SWS_FT_FI39 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
u | LYS413 |