6Y2J

Crystal structure of M. tuberculosis KasA in complex with 4,4,4-trifluoro-N-(isoquinolin-6-yl)butane-1-sulfonamide

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
AAA	0005515	molecular_function	protein binding
AAA	0005737	cellular_component	cytoplasm
AAA	0005829	cellular_component	cytosol
AAA	0005886	cellular_component	plasma membrane
AAA	0006629	biological_process	lipid metabolic process
AAA	0006631	biological_process	fatty acid metabolic process
AAA	0006633	biological_process	fatty acid biosynthetic process
AAA	0009274	cellular_component	peptidoglycan-based cell wall
AAA	0016740	molecular_function	transferase activity
AAA	0016746	molecular_function	acyltransferase activity
AAA	0019367	biological_process	fatty acid elongation, saturated fatty acid
AAA	0030497	biological_process	fatty acid elongation
AAA	0042802	molecular_function	identical protein binding
BBB	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
BBB	0005515	molecular_function	protein binding
BBB	0005737	cellular_component	cytoplasm
BBB	0005829	cellular_component	cytosol
BBB	0005886	cellular_component	plasma membrane
BBB	0006629	biological_process	lipid metabolic process
BBB	0006631	biological_process	fatty acid metabolic process
BBB	0006633	biological_process	fatty acid biosynthetic process
BBB	0009274	cellular_component	peptidoglycan-based cell wall
BBB	0016740	molecular_function	transferase activity
BBB	0016746	molecular_function	acyltransferase activity
BBB	0019367	biological_process	fatty acid elongation, saturated fatty acid
BBB	0030497	biological_process	fatty acid elongation
BBB	0042802	molecular_function	identical protein binding
CCC	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
CCC	0005515	molecular_function	protein binding
CCC	0005737	cellular_component	cytoplasm
CCC	0005829	cellular_component	cytosol
CCC	0005886	cellular_component	plasma membrane
CCC	0006629	biological_process	lipid metabolic process
CCC	0006631	biological_process	fatty acid metabolic process
CCC	0006633	biological_process	fatty acid biosynthetic process
CCC	0009274	cellular_component	peptidoglycan-based cell wall
CCC	0016740	molecular_function	transferase activity
CCC	0016746	molecular_function	acyltransferase activity
CCC	0019367	biological_process	fatty acid elongation, saturated fatty acid
CCC	0030497	biological_process	fatty acid elongation
CCC	0042802	molecular_function	identical protein binding
DDD	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
DDD	0005515	molecular_function	protein binding
DDD	0005737	cellular_component	cytoplasm
DDD	0005829	cellular_component	cytosol
DDD	0005886	cellular_component	plasma membrane
DDD	0006629	biological_process	lipid metabolic process
DDD	0006631	biological_process	fatty acid metabolic process
DDD	0006633	biological_process	fatty acid biosynthetic process
DDD	0009274	cellular_component	peptidoglycan-based cell wall
DDD	0016740	molecular_function	transferase activity
DDD	0016746	molecular_function	acyltransferase activity
DDD	0019367	biological_process	fatty acid elongation, saturated fatty acid
DDD	0030497	biological_process	fatty acid elongation
DDD	0042802	molecular_function	identical protein binding
EEE	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
EEE	0005515	molecular_function	protein binding
EEE	0005737	cellular_component	cytoplasm
EEE	0005829	cellular_component	cytosol
EEE	0005886	cellular_component	plasma membrane
EEE	0006629	biological_process	lipid metabolic process
EEE	0006631	biological_process	fatty acid metabolic process
EEE	0006633	biological_process	fatty acid biosynthetic process
EEE	0009274	cellular_component	peptidoglycan-based cell wall
EEE	0016740	molecular_function	transferase activity
EEE	0016746	molecular_function	acyltransferase activity
EEE	0019367	biological_process	fatty acid elongation, saturated fatty acid
EEE	0030497	biological_process	fatty acid elongation
EEE	0042802	molecular_function	identical protein binding
FFF	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
FFF	0005515	molecular_function	protein binding
FFF	0005737	cellular_component	cytoplasm
FFF	0005829	cellular_component	cytosol
FFF	0005886	cellular_component	plasma membrane
FFF	0006629	biological_process	lipid metabolic process
FFF	0006631	biological_process	fatty acid metabolic process
FFF	0006633	biological_process	fatty acid biosynthetic process
FFF	0009274	cellular_component	peptidoglycan-based cell wall
FFF	0016740	molecular_function	transferase activity
FFF	0016746	molecular_function	acyltransferase activity
FFF	0019367	biological_process	fatty acid elongation, saturated fatty acid
FFF	0030497	biological_process	fatty acid elongation
FFF	0042802	molecular_function	identical protein binding
GGG	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
GGG	0005515	molecular_function	protein binding
GGG	0005737	cellular_component	cytoplasm
GGG	0005829	cellular_component	cytosol
GGG	0005886	cellular_component	plasma membrane
GGG	0006629	biological_process	lipid metabolic process
GGG	0006631	biological_process	fatty acid metabolic process
GGG	0006633	biological_process	fatty acid biosynthetic process
GGG	0009274	cellular_component	peptidoglycan-based cell wall
GGG	0016740	molecular_function	transferase activity
GGG	0016746	molecular_function	acyltransferase activity
GGG	0019367	biological_process	fatty acid elongation, saturated fatty acid
GGG	0030497	biological_process	fatty acid elongation
GGG	0042802	molecular_function	identical protein binding
HHH	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
HHH	0005515	molecular_function	protein binding
HHH	0005737	cellular_component	cytoplasm
HHH	0005829	cellular_component	cytosol
HHH	0005886	cellular_component	plasma membrane
HHH	0006629	biological_process	lipid metabolic process
HHH	0006631	biological_process	fatty acid metabolic process
HHH	0006633	biological_process	fatty acid biosynthetic process
HHH	0009274	cellular_component	peptidoglycan-based cell wall
HHH	0016740	molecular_function	transferase activity
HHH	0016746	molecular_function	acyltransferase activity
HHH	0019367	biological_process	fatty acid elongation, saturated fatty acid
HHH	0030497	biological_process	fatty acid elongation
HHH	0042802	molecular_function	identical protein binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3232
Details	Domain: {"description":"Ketosynthase family 3 (KS3)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19604480","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24108128","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24479625","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Active site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19604480","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24108128","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Site: {"description":"Interacts with the inhibitor thiolactomycin","evidences":[{"source":"PubMed","id":"19604480","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24108128","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---