Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6Y2J

Crystal structure of M. tuberculosis KasA in complex with 4,4,4-trifluoro-N-(isoquinolin-6-yl)butane-1-sulfonamide

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
AAA	0005515	molecular_function	protein binding
AAA	0005737	cellular_component	cytoplasm
AAA	0005829	cellular_component	cytosol
AAA	0005886	cellular_component	plasma membrane
AAA	0006633	biological_process	fatty acid biosynthetic process
AAA	0009274	cellular_component	peptidoglycan-based cell wall
AAA	0016746	molecular_function	acyltransferase activity
AAA	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
AAA	0019367	biological_process	fatty acid elongation, saturated fatty acid
AAA	0030497	biological_process	fatty acid elongation
AAA	0042802	molecular_function	identical protein binding
BBB	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
BBB	0005515	molecular_function	protein binding
BBB	0005737	cellular_component	cytoplasm
BBB	0005829	cellular_component	cytosol
BBB	0005886	cellular_component	plasma membrane
BBB	0006633	biological_process	fatty acid biosynthetic process
BBB	0009274	cellular_component	peptidoglycan-based cell wall
BBB	0016746	molecular_function	acyltransferase activity
BBB	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
BBB	0019367	biological_process	fatty acid elongation, saturated fatty acid
BBB	0030497	biological_process	fatty acid elongation
BBB	0042802	molecular_function	identical protein binding
CCC	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
CCC	0005515	molecular_function	protein binding
CCC	0005737	cellular_component	cytoplasm
CCC	0005829	cellular_component	cytosol
CCC	0005886	cellular_component	plasma membrane
CCC	0006633	biological_process	fatty acid biosynthetic process
CCC	0009274	cellular_component	peptidoglycan-based cell wall
CCC	0016746	molecular_function	acyltransferase activity
CCC	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
CCC	0019367	biological_process	fatty acid elongation, saturated fatty acid
CCC	0030497	biological_process	fatty acid elongation
CCC	0042802	molecular_function	identical protein binding
DDD	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
DDD	0005515	molecular_function	protein binding
DDD	0005737	cellular_component	cytoplasm
DDD	0005829	cellular_component	cytosol
DDD	0005886	cellular_component	plasma membrane
DDD	0006633	biological_process	fatty acid biosynthetic process
DDD	0009274	cellular_component	peptidoglycan-based cell wall
DDD	0016746	molecular_function	acyltransferase activity
DDD	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
DDD	0019367	biological_process	fatty acid elongation, saturated fatty acid
DDD	0030497	biological_process	fatty acid elongation
DDD	0042802	molecular_function	identical protein binding
EEE	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
EEE	0005515	molecular_function	protein binding
EEE	0005737	cellular_component	cytoplasm
EEE	0005829	cellular_component	cytosol
EEE	0005886	cellular_component	plasma membrane
EEE	0006633	biological_process	fatty acid biosynthetic process
EEE	0009274	cellular_component	peptidoglycan-based cell wall
EEE	0016746	molecular_function	acyltransferase activity
EEE	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
EEE	0019367	biological_process	fatty acid elongation, saturated fatty acid
EEE	0030497	biological_process	fatty acid elongation
EEE	0042802	molecular_function	identical protein binding
FFF	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
FFF	0005515	molecular_function	protein binding
FFF	0005737	cellular_component	cytoplasm
FFF	0005829	cellular_component	cytosol
FFF	0005886	cellular_component	plasma membrane
FFF	0006633	biological_process	fatty acid biosynthetic process
FFF	0009274	cellular_component	peptidoglycan-based cell wall
FFF	0016746	molecular_function	acyltransferase activity
FFF	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
FFF	0019367	biological_process	fatty acid elongation, saturated fatty acid
FFF	0030497	biological_process	fatty acid elongation
FFF	0042802	molecular_function	identical protein binding
GGG	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
GGG	0005515	molecular_function	protein binding
GGG	0005737	cellular_component	cytoplasm
GGG	0005829	cellular_component	cytosol
GGG	0005886	cellular_component	plasma membrane
GGG	0006633	biological_process	fatty acid biosynthetic process
GGG	0009274	cellular_component	peptidoglycan-based cell wall
GGG	0016746	molecular_function	acyltransferase activity
GGG	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
GGG	0019367	biological_process	fatty acid elongation, saturated fatty acid
GGG	0030497	biological_process	fatty acid elongation
GGG	0042802	molecular_function	identical protein binding
HHH	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
HHH	0005515	molecular_function	protein binding
HHH	0005737	cellular_component	cytoplasm
HHH	0005829	cellular_component	cytosol
HHH	0005886	cellular_component	plasma membrane
HHH	0006633	biological_process	fatty acid biosynthetic process
HHH	0009274	cellular_component	peptidoglycan-based cell wall
HHH	0016746	molecular_function	acyltransferase activity
HHH	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
HHH	0019367	biological_process	fatty acid elongation, saturated fatty acid
HHH	0030497	biological_process	fatty acid elongation
HHH	0042802	molecular_function	identical protein binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: For beta-ketoacyl synthase activity => ECO:0000255\|PROSITE-ProRule:PRU01348, ECO:0000305\|PubMed:19604480, ECO:0000305\|PubMed:24108128, ECO:0000305\|PubMed:24479625

Chain	Residue	Details
AAA	CYS171
BBB	CYS171
CCC	CYS171
DDD	CYS171
EEE	CYS171
FFF	CYS171
GGG	CYS171
HHH	CYS171

site_id	SWS_FT_FI2
Number of Residues	16
Details	ACT_SITE: For beta-ketoacyl synthase activity => ECO:0000255\|PROSITE-ProRule:PRU01348

Chain	Residue	Details
AAA	HIS311
EEE	HIS345
FFF	HIS311
FFF	HIS345
GGG	HIS311
GGG	HIS345
HHH	HIS311
HHH	HIS345
AAA	HIS345
BBB	HIS311
BBB	HIS345
CCC	HIS311
CCC	HIS345
DDD	HIS311
DDD	HIS345
EEE	HIS311

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000305\|PubMed:19604480, ECO:0000305\|PubMed:24108128

Chain	Residue	Details
AAA	HIS311
EEE	HIS345
FFF	HIS311
FFF	HIS345
GGG	HIS311
GGG	HIS345
HHH	HIS311
HHH	HIS345
AAA	HIS345
BBB	HIS311
BBB	HIS345
CCC	HIS311
CCC	HIS345
DDD	HIS311
DDD	HIS345
EEE	HIS311

site_id	SWS_FT_FI4
Number of Residues	24
Details	SITE: Interacts with the inhibitor thiolactomycin => ECO:0000269\|PubMed:19604480, ECO:0000269\|PubMed:24108128

Chain	Residue	Details
AAA	CYS171
DDD	CYS171
DDD	HIS311
DDD	HIS345
EEE	CYS171
EEE	HIS311
EEE	HIS345
FFF	CYS171
FFF	HIS311
FFF	HIS345
GGG	CYS171
AAA	HIS311
GGG	HIS311
GGG	HIS345
HHH	CYS171
HHH	HIS311
HHH	HIS345
AAA	HIS345
BBB	CYS171
BBB	HIS311
BBB	HIS345
CCC	CYS171
CCC	HIS311
CCC	HIS345

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)